Differentiation of the brain vasculature : the answer came blowing by the Wnt [PDF]
, 2010 Vascularization of the vertebrate brain takes place during embryonic development from a preformed perineural vascular plexus. As a consequence of the intimate contact with neuroectodermal cells the vessels, which are entering the brain exclusively via ...
Liebner, Stefan +3 more
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Wnt Signaling Regulates Multipolar-to-Bipolar Transition of Migrating Neurons in the Cerebral Cortex
Cell Reports, 2015 The precise timing of pyramidal cell migration from the ventricular germinal zone to the cortical plate is essential for establishing cortical layers, and migration errors can lead to neurodevelopmental disorders underlying psychiatric and neurological ...
Michael Boitard +8 more
doaj +1 more source
Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways
eLife, 2015 The intracellular signaling molecule Dishevelled (Dvl) mediates canonical and non-canonical Wnt signaling via its PDZ domain. Different pathways diverge at this point by a mechanism that remains unclear.
Ho-Jin Lee, De-Li Shi, Jie J Zheng
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The canonical Wnt/β-catenin pathway: From the history of its discovery to clinical application [PDF]
Терапевтический архив, 2016 The Wnt/β signaling pathway (Wnt-SP) is a phylogenetically ancient mechanism that regulates development and maintains tissue homeostasis through the control of cell proliferation, differentiation, migration, and apoptosis.
T A Grebennikova +3 more
doaj +1 more source
Dissecting the roles of WNT signaling in breast cancer using "in vitro" and "in vivo" experimental models [PDF]
, 2009 Canonical WNT pathway regulates expression of target genes by modulating intracellular amount of β-catenin. Without WNT pathway activation, a so-called “destruction complex” including APC and Axin facilitates the degradation of β-catenin. Upon binding of
Matsuda, Yutaka
core +1 more source
Frontiers in Oncology, 2023 IntroductionCancer Stem Cells (CSC) are responsible for maintaining tumor growth, chemoresistance, and metastasis. Therefore, understanding their characteristics is critical to progress in cancer therapy.
Miguel Angel Sarabia-Sánchez +5 more
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Multiple Targets of the Canonical WNT/β-Catenin Signaling in Cancers
Frontiers in Oncology, 2019 Canonical WNT/β-catenin signaling is involved in most of the mechanisms that lead to the formation and development of cancer cells. It plays a central role in three cyclic processes, which are the cell division cycle, the immune cycle, and circadian ...
Yves Lecarpentier +4 more
doaj +1 more source
Canonical Wnt Signaling Pathway on Polarity Formation of Utricle Hair Cells
Neural Plasticity, 2021 As part of the inner ear, the vestibular system is responsible for sense of balance, which consists of three semicircular canals, the utricle, and the saccule.
Di Deng +8 more
doaj +1 more source
Dissecting the impact of Frizzled receptors in Wnt/beta-catenin signaling of human mesenchymal stem cells [PDF]
, 2012 Wnt/beta-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs).
Ruiz-Heinrich, Lourdes +18 more
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source