Results 31 to 40 of about 75,163 (297)

Augmenting endogenous wnt signaling improves skin wound healing [PDF]

, 2013
Wnt signaling is required for both the development and homeostasis of the skin, yet its contribution to skin wound repair remains controversial. By employing Axin2(LacZ/+) reporter mice we evaluated the spatial and temporal distribution patterns of Wnt ...
Manzano Wilfred R., Fang Mark Y., Girija R Dhamdhere, Anthony E. Oro, Bo Liu, Fang, Mark Y, Whyte, Jemima L., Helms Jill A., Wilfred R. Manzano, Nick D. Evans (474290), Manzano, Wilfred R, Howard Y. Chang (215450), Smith, Andrew A, Manzano, Wilfred R., Whyte, Jemima L, Jemima L. Whyte (474287), Nick D Evans, Helms, Jill A., Andrew A Smith, Anthony E Oro, Andrew A. Smith (474288), Oro Anthony E., Chang, Howard Y., Jemima L Whyte, Liu Bo, Howard Y Chang, Dhamdhere, Girija R, Evans Nick D., Evans, Nick D., Wilfred R. Manzano (474289), Oro, Anthony E., Nick D. Evans¤a, Smith Andrew A., Whyte Jemima L., Liu, Bo, Mark Y. Fang (474292), Wilfred R Manzano, Jill A. Helms (25398), Fang, Mark Y., Smith, Andrew A., Andrew A. Smith, Evans, Nick D, Helms, Jill A, Girija R. Dhamdhere (474291), Girija R. Dhamdhere, Jill A Helms, Mark Y. Fang¤b, Anthony E. Oro (474293), Jill A. Helms, Dhamdhere, Girija R., Mark Y Fang, Chang, Howard Y, Chang Howard Y., Jemima L. Whyte, Oro, Anthony E, Howard Y. Chang, Bo Liu (127343), Dhamdhere Girija R.   +57 more
core   +1 more source

Functional conservation of Nematostella Wnts in canonical and noncanonical Wnt-signaling [PDF]

Biology Open, 2011
Summary Cnidarians surprise by the completeness of Wnt gene subfamilies (11) expressed in an overlapping pattern along the anterior-posterior axis. While the functional conservation of canonical Wnt-signaling components in cnidarian gastrulation and organizer formation is evident, a role of Nematostella Wnts in noncanonical Wnt-signaling
T Rigo-Watermeier, B Kraft, M Ritthaler, V Wallkamm, T Holstein, D Wedlich   +5 more
openaire   +3 more sources

Determining zebrafish dorsal organizer size by a negative feedback loop between canonical/non-canonical Wnts and Tlr4/NFκB

Nature Communications, 2023
In vertebrate embryos, the canonical Wnt ligand primes the formation of dorsal organizers that govern dorsal-ventral patterns by secreting BMP antagonists.
Juqi Zou, Satoshi Anai, Satoshi Ota, Shizuka Ishitani, Masayuki Oginuma, Tohru Ishitani   +5 more
doaj   +1 more source

A phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling [PDF]

, 2013
Zebrafish have recently emerged as an attractive model for the in vivo bioassay-guided isolation and characterization of pharmacologically active small molecules of natural origin.
Alexander D. Crawford, Crawford, Alexander D, Alexander I. Gray, Cordero-Maldonado, María Lorena, de Witte, Peter A M, Gray, Alexander I, Alan L Harvey, Camila V. Esguerra, Gebruers, Evelien, Evelien Gebruers, Harvey, Alan L, Carol Clements, Clements, Carol, Alexander D Crawford, Edrada-Ebel, Ruangelie, Camila V Esguerra, Alan L. Harvey, Ruangelie Edrada-Ebel, Esguerra, Camila V, María Lorena Cordero-Maldonado, Alexander I Gray, Peter A M de Witte, Cordero Maldonado, María Lorena, Peter A. M. de Witte   +23 more
core   +1 more source

Transient Deregulation of Canonical Wnt Signaling in Developing Pyramidal Neurons Leads to Dendritic Defects and Impaired Behavior

Cell Reports, 2019
Summary: During development, the precise implementation of molecular programs is a key determinant of proper dendritic development. Here, we demonstrate that canonical Wnt signaling is active in dendritic bundle-forming layer II pyramidal neurons of the ...
Beatrice Viale, Lin Song, Volodymyr Petrenko, Anne-Laure Wenger Combremont, Alessandro Contestabile, Riccardo Bocchi, Patrick Salmon, Alan Carleton, Lijia An, Laszlo Vutskits, Jozsef Zoltan Kiss   +10 more
doaj   +1 more source

Transcriptomic Identification of Draxin-Responsive Targets During Cranial Neural Crest EMT

Frontiers in Physiology, 2021
Canonical Wnt signaling plays an essential role in proper craniofacial morphogenesis, at least partially due to regulation of various aspects of cranial neural crest development.
Erica J. Hutchins, Michael L. Piacentino, Marianne E. Bronner   +2 more
doaj   +1 more source

Canonical Wnt signaling in diabetic retinopathy

Vision Research, 2017
Diabetic retinopathy (DR) is a common eye complication of diabetes, and the pathogenic mechanism of DR is still under investigation. The canonical Wnt signaling pathway is an evolutionarily conserved pathway that plays fundamental roles in embryogenesis and adult tissue homeostasis.
Qian, Chen, Jian-Xing, Ma
openaire   +2 more sources

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling [PDF]

Nature, 2017
Wnt proteins modulate cell proliferation and differentiation and the self-renewal of stem cells by inducing β-catenin-dependent signalling through the Wnt receptor frizzled (FZD) and the co-receptors LRP5 and LRP6 to regulate cell fate decisions and the growth and repair of several tissues.
Claudia Y. Janda, Luke T. Dang, Changjiang You, Junlei Chang, Wim de Lau, Zhendong A. Zhong, Kelley S. Yan, Owen Marecic, Dirk Siepe, Xingnan Li, James D. Moody, Bart O. Williams, Hans Clevers, Jacob Piehler, David Baker 0001, Calvin J. Kuo, K. Christopher Garcia   +16 more
openaire   +3 more sources

Differentiation of the brain vasculature : the answer came blowing by the Wnt [PDF]

, 2010
Vascularization of the vertebrate brain takes place during embryonic development from a preformed perineural vascular plexus. As a consequence of the intimate contact with neuroectodermal cells the vessels, which are entering the brain exclusively via ...
Liebner, Stefan, Plate, Karl, Stefan Liebner, Karl H Plate   +3 more
core   +1 more source

Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells.

PLoS ONE, 2015
The Wnt system is highly complex and is comprised of canonical and non-canonical pathways leading to the activation of gene expression. Our aim was to examine changes in the expression of Wnt ligands and regulators during hepatic stellate cell (HSC ...
Laura Corbett, Jelena Mann, Derek A Mann
doaj   +1 more source