Results 11 to 20 of about 75,163 (297)
Role of Wnt canonical pathway in hematological malignancies [PDF]
Journal of Hematology & Oncology, 2010 Wnt canonical signaling pathway plays a diverse role in embryonic development and maintenance of organs and tissues in adults. It has been observed that Wnt/β-catenin signaling pathway is involved in the pathogenesis of many carcinomas.
Wang Xin, GE Xueling
doaj +6 more sources
Wnt Signaling Upregulates Teneurin-3 Expression via Canonical and Non-canonical Wnt Pathway Crosstalk [PDF]
Frontiers in Neuroscience, 2019 Teneurins (Tens) are a highly conserved family of proteins necessary for cell-cell adhesion. Tens can be cleaved, and some of their proteolytic products, such as the teneurin c-terminal associated-peptide (TCAP) and the intracellular domain (ICD), have ...
Sussy Bastías-Candia +7 more
doaj +5 more sources
Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling [PDF]
Nature Communications, 2014 Wnt proteins control diverse biological processes through β-catenin-dependent canonical signalling and β-catenin-independent non-canonical signalling. The mechanisms by which these signalling pathways are differentially triggered and controlled are not fully understood.
Ren Sheng +10 more
core +8 more sources
Non-canonical Wnt signaling in the eye [PDF]
Progress in Retinal and Eye Research, 2023 Wnt signaling comprises a group of complex signal transduction pathways that play critical roles in cell proliferation, differentiation, and apoptosis during development, as well as in stem cell maintenance and adult tissue homeostasis. Wnt pathways are classified into two major groups, canonical (β-catenin-dependent) or non-canonical (β-catenin ...
Shah, Ruchi +6 more
openaire +5 more sources
Differential expression of canonical and non‐canonical Wnt ligands in ameloblastoma [PDF]
Journal of Oral Pathology & Medicine, 2011 J Oral Pathol Med (2012) 41: 332–339Background: Canonical and non‐canonical Wnt signaling pathways modulate diverse cellular processes during embryogenesis and post‐natally. Their deregulations have been implicated in cancer development and progression. Wnt signaling is essential for odontogenesis.
Siar, C.H. +7 more
core +7 more sources
Canonical Wnt Signaling Protects Hippocampal Neurons from Aβ Oligomers: Role of Non-Canonical Wnt-5a/Ca2+ in Mitochondrial Dynamics [PDF]
Frontiers in Cellular Neuroscience, 2013 Alzheimer´s disease (AD) is the most common type of age-related dementia. The disease is characterized by a progressive loss of cognitive abilities, severe neurodegeneration, synaptic loss and mitochondrial dysfunction.
Carmen eSilva-Alvarez +5 more
doaj +2 more sources
Wnt Glycation Inhibits Canonical Signaling [PDF]
Cells, 2019 Glycation occurs as a non-enzymatic reaction between amino and thiol groups of proteins, lipids, and nucleotides with reducing sugars or α-dicarbonyl metabolites.
Zhennan Ye +5 more
doaj +3 more sources
Cushioning the cartilage: a canonical Wnt restricting matter [PDF]
Nature Reviews Rheumatology, 2017 Wnt signalling pathways have key roles in joint development, homeostasis and disease, particularly in osteoarthritis. New data is starting to reveal the importance of tightly regulating canonical Wnt signalling pathway activation to maintain homeostasis and health in articular cartilage.
Silvia, Monteagudo, Rik J, Lories
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Blood advances, 2021 Myeloid dysplastic syndrome (MDS) reflects a preleukemic bone marrow (BM) disorder with limited treatment options and poor disease survival. As only a minority of MDS patients are eligible for curative hematopoietic stem cell transplantation, there is an urgent need to develop alternative treatment options.
Krimpenfort, Rosa A, Nethe, Micha
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Cell Biology of Canonical Wnt Signaling [PDF]
Annual Review of Cell and Developmental Biology, 2021 Wnt signaling has multiple functions beyond the transcriptional effects of β-catenin stabilization. We review recent investigations that uncover new cell physiological effects through the regulation of Wnt receptor endocytosis, Wnt-induced stabilization of proteins (Wnt-STOP), macropinocytosis, increase in lysosomal activity, and metabolic changes ...
Albrecht, Lauren V +2 more
openaire +3 more sources