Wnt Signaling Upregulates Teneurin-3 Expression via Canonical and Non-canonical Wnt Pathway Crosstalk [PDF]
Frontiers in Neuroscience, 2019 Teneurins (Tens) are a highly conserved family of proteins necessary for cell-cell adhesion. Tens can be cleaved, and some of their proteolytic products, such as the teneurin c-terminal associated-peptide (TCAP) and the intracellular domain (ICD), have ...
Sussy Bastías-Candia +7 more
doaj +2 more sources
WNT signalling in joint repair and homeostasis [PDF]
, 2011 PhDDisruption of the Wnt canonical signalling leads to the development of osteoarthritis both in human and in mice but the underlying molecular mechanisms are poorly understood.
Nalesso, Giovanna
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A phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling [PDF]
, 2013 Zebrafish have recently emerged as an attractive model for the in vivo bioassay-guided isolation and characterization of pharmacologically active small molecules of natural origin.
Alexander D. Crawford +41 more
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Loss of FTO Antagonises Wnt Signaling and Leads to Developmental Defects Associated with Ciliopathies [PDF]
, 2014 Common intronic variants in the Human fat mass and obesity-associated gene (FTO) are found to be associated with an increased risk of obesity. Overexpression of FTO correlates with increased food intake and obesity, whilst loss-of-function results in ...
Rosa Maria Roccasecca (519728) +40 more
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Integration of SHH and WNT pathways controls morphogenesis of the CNS. [PDF]
, 2008 [eng] Dorsoventral patterning of the vertebrate nervous system is achieved by the combined activity of morphogenetic signals secreted from dorsal and ventral signalling centres. The Shh/Gli pathway plays a major role in patterning the ventral neural tube;
Álvarez Medina, José Roberto
core +6 more sources
A novel bidirectional positive feedback loop between Wnt/ -catenin and EGFR/ERK: role of context-specific signalling crosstalk in modulating epithelial tissue regeneration [PDF]
, 2014 By operating as both a subunit of the cadherin complex and a key component of Wnt signalling, β-catenin constitutes the lynchpin between cell:cell contact and transcriptional regulation of proliferation to co-ordinate epithelial tissue homeostasis and ...
Kirkwood, Lisa A. +2 more
core +4 more sources
The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway. [PDF]
, 2015 Ciliopathies are a group of developmental disorders that manifest with multi-organ anomalies. Mutations in TMEM67 (MKS3) cause a range of human ciliopathies, including Meckel-Gruber and Joubert syndromes.
Daniel J. Jagger +21 more
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Persistent Wnt/β-catenin signaling determines dorsalization of the postnatal subventricular zone and neural Stem cell specification into oligodendrocytes and glutamatergic neurons [PDF]
, 2014 In the postnatal and adult central nervous system (CNS), the subventricular zone (SVZ) of the forebrain is the main source of neural stem cells (NSCs) that generate olfactory neurons and oligodendrocytes (OLs), the myelinating cells of the CNS.
Raineteau, Olivier +17 more
core +1 more source
Cell Reports, 2019 Summary: During development, the precise implementation of molecular programs is a key determinant of proper dendritic development. Here, we demonstrate that canonical Wnt signaling is active in dendritic bundle-forming layer II pyramidal neurons of the ...
Beatrice Viale +10 more
doaj +1 more source
Transcriptomic Identification of Draxin-Responsive Targets During Cranial Neural Crest EMT
Frontiers in Physiology, 2021 Canonical Wnt signaling plays an essential role in proper craniofacial morphogenesis, at least partially due to regulation of various aspects of cranial neural crest development.
Erica J. Hutchins +2 more
doaj +1 more source