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The Wnt signalling pathway [PDF]
Journal of Cell Science, 2002 Recent advances in the field require an update of our Wnt pathway scheme ( [Hulsken and Behrens, 2000][1]). Intracellular signaling of the Wnt pathway diversifies into at least three branches: (1) the β-catenin pathway (canonical Wnt pathway, blue), which activates target genes in the nucleus ...
Joerg, Huelsken, Juergen, Behrens
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Cancer Management and Research, 2020 Mao-Hua Ping Department of Rehabilitation Medicine, Hanyang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei Province 430050, People ’s Republic of ChinaCorrespondence: Mao-Hua PingDepartment of Rehabilitation ...
Ping MH
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Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition
Molecular & Cellular Oncology, 2018 Cancer cell dormancy is an important source of treatment failure. We studied the molecular characteristics and functional behaviour of dormant colorectal cancer cells finding them to be a differentiated yet plastic population.
Semiramis A. Popova +1 more
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Diseases of Wnt signaling [PDF]
Reviews in Endocrine and Metabolic Disorders, 2006 The Wnt signaling pathways play fundamental roles in the differentiation, proliferation, death and function of many cells and as a result are involved in critical developmental, growth and homeostatic processes in animals. There are four currently known pathways of Wnt signaling; the so-called canonical or Wnt/beta-catenin pathway, the Wnt/Ca(+2 ...
Mark L, Johnson, Nalini, Rajamannan
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Receptor and secreted targets of Wnt-1/β-catenin signalling in mouse mammary epithelial cells
BMC Cancer, 2005 Background Deregulation of the Wnt/ β-catenin signal transduction pathway has been implicated in the pathogenesis of tumours in the mammary gland, colon and other tissues.
Enver Tariq +2 more
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La vía Wnt/β-catenina disminuye la cantidad de osteoclastos en el hueso y favorece su apoptosis
Revista de Osteoporosis y Metabolismo Mineral, 2019 La activación de la señalización de Wnt/β-catenina en células del linaje osteoblástico conduce a un aumento en la masa ósea a través de un mecanismo dual: por una parte, aumentando la osteoblastogénesis, y por otra, disminuyendo la osteoclastogénesis. El
Martín-Millán M +5 more
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RNA干扰pygo2基因对人脑胶质母细胞瘤U251生物学行为及wnt通路的影响
Zhongguo shiyan zhenduanxue, 2015 目的研究pygo2在胶质瘤细胞系U251中的表达、功能及作用机制。方法利用反义pygo2转染U251,下调pygo2的表达,应用流式细胞术和MTT法,评价细胞生长、增殖、凋亡及周期变化;细胞克隆形成试验和transwell侵袭试验分析细胞的克隆形成能力和侵袭能力,采用Western印迹法检测通路蛋白的表达变化。结果转染反义pygo2后,pygo2表达降低,MTT结果显示转染反义pygo2后细胞生长受到抑制且凋亡细胞增加;流式细胞术提示G1期到S期阻滞,细胞克隆形成能力下降,侵袭能力均受到抑制 ...
傅建华 +4 more
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β-Catenin inhibition shapes tumor immunity and synergizes with immunotherapy in colorectal cancer
OncoImmunology, 2020 In colorectal cancer, Wnt/β-catenin signaling is often aberrantly activated and associated with a T-cell-excluded phenotype which is a major obstacle for many immunotherapies.
Caihong Wang +6 more
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Unleashing Wnts: Wnt ligands fuel cancer spread
Journal of Cancer BiologyWnt signaling has long been implicated in cancer development, but recent studies have revealed new insights into how Wnt ligands themselves drive metastasis. Currently, research identifies Wnt1, Wnt2, Wnt2b, Wnt3, Wnt3a, Wnt4, Wnt5a, Wnt5b, Wnt6, Wnt8a, Wnt9b, Wnt10a, Wnt10b, and Wnt16 as pro-metastatic Wnt ligands, while Wnt7a, Wnt7b, Wnt8b, Wnt9a ...
Caroland, Kailey P. +3 more
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