Results 1 to 10 of about 408,842 (307)

A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3

Cell Death and Disease, 2021
Polyglutamine (polyQ) diseases comprise Huntington’s disease and several subtypes of spinocerebellar ataxia, including spinocerebellar ataxia type 3 (SCA3).
Zhefan Stephen Chen, Xiaoying Huang, Kevin Talbot, Ho Yin Edwin Chan   +3 more
doaj   +1 more source

Systematic image‐driven analysis of the spatial Drosophila embryonic expression landscape

Molecular Systems Biology, 2010
Discovery of temporal and spatial patterns of gene expression is essential for understanding the regulatory networks and development in multicellular organisms.
Erwin Frise, Ann S Hammonds, Susan E Celniker   +2 more
doaj   +1 more source

Mycobiota, neuro-cognitif disorders and behavioural impairments: is there a relationship?

European Psychiatry, 2023
Introduction The human body carries large and diverse communities of symbiotic microbes that are important for human health and development. While the impact of the bacterial microbiota, which are mostly found in the human gut, on host physiology is ...
B. Abdelmoula, H. Sellami, S. Neji, M. Torjmen, N. Bouayed Abdelmoula   +4 more
doaj   +1 more source

Seeds of moringa (Moringa oleifera) and mucuna (Mucuna pruriens L.) modulate biochemical indices of L-NAME-induced hypertension in rats: A comparative study

Journal of Agriculture and Food Research, 2023
Hypertension is a prevalent cardiovascular condition that affects millions of people worldwide. It is characterized by abnormally high blood pressure in the arteries, leading to an increased risk of heart disease, stroke, and kidney failure. Hypertension
Idowu S. Oyeleye, Opeyemi B. Ogunsuyi, Odunayo O. Oluokun, Ganiyu Oboh   +3 more
doaj   +1 more source

Ecofriendly silver nanoparticle synthesis, physicochemical characterization from Datura stramonium, and its biological applications in Parkinson Drosophila model

ASPET Discovery
Parkinson disease (PD) is a progressive neurodegenerative disorder driven by mitochondrial dysfunction and oxidative stress. Central to its pathology is the disruption of PINK1 (PTEN-induced kinase 1)-mediated mitophagy, which plays a critical role in ...
Bothe Thokchom, Santosh Mallikarjun Bhavi, Sapam Riches Singh, Megha B. Abbigeri, Akshata Choudhari Padti, Sudheendra Rao Kulkarni, Vemuluri Sailaja, Ramesh Babu Yarajarla   +7 more
doaj   +1 more source

A Novel Method for Primary Blood Cell Culturing and Selection in Drosophila melanogaster

Cells, 2022
The blood cells of the fruit fly Drosophila melanogaster show many similarities to their vertebrate counterparts, both in their functions and their differentiation.
Enikő Kúthy-Sutus, Bayan Kharrat, Erika Gábor, Gábor Csordás, Rita Sinka, Viktor Honti   +5 more
doaj   +1 more source

Establishment of Drosophila intestinal cell lines as tools for multiomic screening and deciphering intestinal biology

Scientific Reports
The Drosophila intestine is a powerful model for stem cell dynamics and epithelial biology, yet no intestinal derived cell lines have been available until now. Here, we describe the establishment of Drosophila intestinal cell lines.
Arthur Luhur, Daniel Mariyappa, Peter Bohall, Laura Multini, Morgan Elkins, Andrew C. Zelhof   +5 more
doaj   +1 more source

A study on the antioxidant, cytotoxicity, and coagulation potential of carbon quantum dots derived from the leaves of Lagerstroemia speciosa

Hybrid Advances
The green synthesis of carbon quantum dots (CQDs) from natural sources offers a sustainable approach in nanotechnology. In this study, CQDs were synthesized from Lagerstroemia speciosa leaves (LS-CQDs) and extensively characterized for their optical ...
Sapam Riches Singh, Gouramma R. Kanamadi, Bothe Thokchom, Santosh Mallikarjun Bhavi, Megha B. Abbigeri, Pooja Joshi, Sudheendra Rao Kulkarni, Akshata Choudhari Padti, B.P. Harini, Ramesh Babu Yarajarla   +9 more
doaj   +1 more source

The natverse, a versatile toolbox for combining and analysing neuroanatomical data

eLife, 2020
To analyse neuron data at scale, neuroscientists expend substantial effort reading documentation, installing dependencies and moving between analysis and visualisation environments.
Alexander Shakeel Bates, James D Manton, Sridhar R Jagannathan, Marta Costa, Philipp Schlegel, Torsten Rohlfing, Gregory SXE Jefferis   +6 more
doaj   +1 more source

Pooled genome-wide CRISPR activation screening for rapamycin resistance genes in Drosophila cells

eLife, 2023
Loss-of-function and gain-of-function genetic perturbations provide valuable insights into gene function. In Drosophila cells, while genome-wide loss-of-function screens have been extensively used to reveal mechanisms of a variety of biological processes,
Baolong Xia, Raghuvir Viswanatha, Yanhui Hu, Stephanie E Mohr, Norbert Perrimon   +4 more
doaj   +1 more source