Results 41 to 50 of about 427,328 (297)

Rethinking WNT signalling [PDF]

Nature, 2018
The identification of genetic mutations that can hinder the development of human limbs has led to the discovery of an unanticipated mode of regulation for the WNT signalling pathway during limb development. The identification of genetic mutations that can hinder the development of human limbs has led to the discovery of an unanticipated mode of ...
Jessica A, Lehoczky, Clifford J, Tabin
openaire   +2 more sources

Morphogenesis and axis specification occur in parallel during optic cup and optic fissure formation, differentially modulated by BMP and Wnt [PDF]

Open Biology, 2019
Optic cup morphogenesis is an intricate process. Especially, the formation of the optic fissure is not well understood. Persisting optic fissures, termed coloboma, are frequent causes for congenital blindness.
Priska Eckert, Max D. Knickmeyer, Lucas Schütz, Joachim Wittbrodt, Stephan Heermann   +4 more
doaj   +1 more source

Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human

, 2019
The Hedgehog (Hh) and Wnt/β-Catenin (Wnt) cascades are morphogen pathways whose pronounced influence on adult liver metabolism has been identified in recent years.
Aleithe, S., Brosch, M., Brusch, L., Damm, G., Gajowski, R., Gebhardt, R., Hampe, J., Hoehme, S., Hoffmann, U., Kolbe, E., Kücken, M., Matz-Soja, M., Meierhofer, D., Ott, F., Rennert, C., Schafmayer, C., Seehofer, D., Seifert, M., Spormann, L., Stöpel, C., von Schoenfels, W.   +20 more
core   +1 more source

Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth [PDF]

, 2017
Bone morphogenetic proteins (Bmp) are well-known to induce bone formation following chondrogenesis, but the direct role of Bmp signaling in the osteoblast lineage is not completely understood.
Bellido, Teresita, He, Guangxu, Lim, Joohyun, Long, Fanxin, Ni, Jiangdong, Shi, Yu   +5 more
core   +3 more sources

Axing Wnt signals [PDF]

Cell Research, 2011
Wnt signaling is a highly conserved and context-dependent signal transduction pathway that belongs to the so-called morphogens. Wnt signals are instrumental during development, but also play a central role in tissue homeostasis. For instance, in the intestine Wnt signaling is crucial for both stem cell maintenance and proliferation in the transient ...
de Sousa E Melo, Felipe, Medema, Jan Paul   +1 more
openaire   +2 more sources

Cartilage development and degeneration: a Wnt Wnt situation [PDF]

Cell Biochemistry and Function, 2012
The Wnt signaling pathway plays a crucial role in the development and homeostasis of a variety of adult tissues and, as such, is emerging as an important therapeutic target for numerous diseases. Factors involved in the Wnt pathway are expressed throughout limb development and chondrogenesis and have been shown to be critical in joint homeostasis and ...
Katherine Ann, Staines, Vicky Elizabeth, Macrae, Colin, Farquharson   +2 more
openaire   +2 more sources

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]

, 2012
Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Abramsson, Adams, Aicher, Armulik, Arosarena, Augustin, Benedito, Bergers, Blouw, Brastianos, Cancer Genome Atlas Research Network, Carmeliet, Cathrin J. Czupalla, Cattelino, Chien, Claxton, Corada, Daneman, Daneman, Devraj, Ernesto Bockamp, Estrach, Fisher, Franco, Gerhardt, Gerhardt, Harada, Harrington, Hellström, Jadranka Macas, Jakobsson, Jenny Zinke, Kamino, Karl H. Plate, Kavi Devraj, Kotliarova, Li, Liebner, Liebner, Liebner, Liebner, Lobov, Lobov, Lucero, Machein, Mailhos, Makoto M. Taketo, Marco Reis, Marcus Fruttiger, McCarty, Min, Nicole Ziegler, Noguera-Troise, Olsson, Phng, Phng, Rosario Heck, Saharinen, Sascha Seidel, Schneider, Segarra, Siekmann, Smadja, Smolich, Sonja Thom, Stefan Liebner, Stefanie Dimmeler, Stenman, Streit, Thomas, Vleminckx, Willert, Williams, Wolburg, Yano, Yano, Yoshio-Hoshino, Zhang, Zhang, Zhou   +79 more
core   +1 more source

Wnt-1 and Wnt-4 regulate thymic cellularity [PDF]

European Journal of Immunology, 2002
Thymic primordium, formed by cells derived from the endoderm, the ectoderm and the neural crest-derived mesenchyme, receive fetal liver derived lymphoid precursors. Reciprocal cell-cell interactions between thymic stromal cells and lymphoid precursors are critical in the expansion and maturation of thymocytes. Transcription factor TCF-1 is critical for
Thomas, Mulroy, Jill A, McMahon, Steven J, Burakoff, Andrew P, McMahon, Jyoti, Sen   +4 more
openaire   +2 more sources

Canonical WNT pathway inhibition reduces ATP synthesis rates in glioblastoma stem cells

Frontiers in Bioscience-Landmark, 2022
Background: The conserved stem cell signaling network canonical Wingless (WNT) plays important roles in development and disease. Aberrant activation of this pathway has been linked to tumor progression and resistance to therapy.
Dymphna Margriet Ouwens, Michael Hewera, Guanzhang Li, Wang Di, Sajjad Muhammad, Daniel Hänggi, Hans-Jakob Steiger, Claudia A. Dumitru, Erol Sandalcioglu, Roland S Croner, Wei Zhang, Or Kakhlon, Ulf D. Kahlert   +12 more
doaj   +1 more source

Wnt signalling: conquering complexity [PDF]

Development, 2018
ABSTRACT The history of the Wnt pathway is an adventure that takes us from mice and flies to frogs, zebrafish and beyond, sketching the outlines of a molecular signalling cascade along the way. Here, we specifically highlight the instrumental role that developmental biology has played throughout. We take the reader on a journey, starting
Katrin E. Wiese, Roel Nusse, Renée van Amerongen   +2 more
openaire   +4 more sources