Results 61 to 70 of about 239,096 (264)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
WNT5a in Colorectal Cancer: Research Progress and Challenges
Cancer Management and Research, 2021 Guangshun Sun,1,* Liangliang Wu,1,* Guoqiang Sun,1 Xuesong Shi,1 Hongyong Cao,1 Weiwei Tang2 1Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 2Hepatobiliary/Liver ...
Sun G, Wu L, Sun G, Shi X, Cao H, Tang W
doaj
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
The Wnt signalling pathway [PDF]
Journal of Cell Science, 2002 Recent advances in the field require an update of our Wnt pathway scheme ( [Hulsken and Behrens, 2000][1]). Intracellular signaling of the Wnt pathway diversifies into at least three branches: (1) the β-catenin pathway (canonical Wnt pathway, blue), which activates target genes in the nucleus ...
Huelsken, J., Behrens, J.
openaire +3 more sources
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Cancer Management and Research, 2020 Mao-Hua Ping Department of Rehabilitation Medicine, Hanyang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei Province 430050, People ’s Republic of ChinaCorrespondence: Mao-Hua PingDepartment of Rehabilitation ...
Ping MH
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Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition
Molecular & Cellular Oncology, 2018 Cancer cell dormancy is an important source of treatment failure. We studied the molecular characteristics and functional behaviour of dormant colorectal cancer cells finding them to be a differentiated yet plastic population.
Semiramis A. Popova +1 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
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