Results 71 to 80 of about 427,328 (297)

Axon guidance and injury — lessons from Wnts and Wnt signaling [PDF]

Current Opinion in Neurobiology, 2014
Many studies in the past decade have revealed the role and mechanisms of Wnt signaling in axon guidance during development and the reinduction of Wnt signaling in adult central nervous system axons upon traumatic injury, which has profound influences on axon regeneration.
Onishi, Keisuke, Hollis, Edmund, Zou, Yimin   +2 more
openaire   +4 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

NORRIN plays a context-dependent role in glioblastoma stem cells

Molecular & Cellular Oncology, 2020
We recently reported a novel role of the atypical Wnt ligand, NORRIN, in mediating the proliferation and stemness of glioblastoma stem cells. Mechanistic and functional analysis revealed context-specific phenotypes in which NORRIN can induce opposite ...
Ahmed El-Sehemy, Valerie A. Wallace
doaj   +1 more source

Ellagic Acid Attenuates BLM-Induced Pulmonary Fibrosis via Inhibiting Wnt Signaling Pathway

Frontiers in Pharmacology, 2021
Idiopathic pulmonary fibrosis is a progressive lung disease with high mortality and limited therapy that is characterized by epithelial cell damage and fibroblast activation.
Xiaohe Li, Xiaohe Li, Kai Huang, Xiaowei Liu, Xiaowei Liu, Hao Ruan, Hao Ruan, Ling Ma, Ling Ma, Jingjing Liang, Jingjing Liang, Yunyao Cui, Yunyao Cui, Yanhua Wang, Shuyang Wu, Hailong Li, Yuli Wei, Zeping Li, Zeping Li, Jingjing Gao, Bo Yang, Xiaoping Li, Guang Yang, Honggang Zhou, Honggang Zhou, Cheng Yang, Cheng Yang   +26 more
doaj   +1 more source

Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled. [PDF]

, 2015
Frizzled is the earliest discovered glycosylated Wnt protein receptor and is critical for the initiation of Wnt signaling. Antagonizing Frizzled is effective in inhibiting the growth of multiple tumor types.
Baday, Yiressy C, Bao, Ju, Guibao, Cristina, Lee, Ho-Jin, Li, Lin, Miller, Ami, Wu, Dianqing, Wu, Jibo, Zhang, Chi, Zheng, Jie J   +9 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Overcoming resistance to immunotherapy by teaching old drugs new tricks

Molecular & Cellular Oncology, 2020
Cancer stem cells (CSCs) underlie resistance to therapy. Cancer develops only in the context of failing immunosurveillance, and stem cells occupy immune privileged microenvironments.
John M. Perry, Linheng Li
doaj   +1 more source

WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics [PDF]

, 2009
Prostate cancer cells with stem cell characteristics were identified in human prostate cancer cell lines by their ability to form from single cells self-renewing prostaspheres in non-adherent cultures.
A de la Taille, A Glinka, A van Bokhoven, AA George, AP Verhagen, AS Waller, AT Collins, AT Collins, AT Collins, B Hoang, B Mao, BA Reynolds, C Lo Celso, C Wissmann, CC Carson 3rd, CI Truica, CL Hall, CL Hall, D Beier, D Bonnet, D Masiello, D Mizrak, DA Lawson, David M Prowse, DK Singla, DL Hudson, DL Hudson, DP Petrylak, DR Chesire, EM Hurt, G Dontu, G Gu, G Shaw, G Shaw, GD Richardson, GJ van Leenders, GL Shaw, GN Thalmann, H Clevers, H Li, H Zhu, HF English, Isabelle Bisson, IV Litvinov, IV Litvinov, J Miki, JA Schalken, JE Visvader, JM Adams, KD Bunting, KG Leong, L Adam, L Patrawala, L Patrawala, L Patrawala, L Ricci-Vitiani, L Vezzoni, L Xin, L Xin, LE Pascal, LG Wang, M Al-Hajj, M Locke, M Verras, MJ Linja, MS Chen, MS Wicha, N Uchida, PN Kelly, RI Bhatt, S Signoretti, S Weiss, S Zhou, SI Hwang, SK Singh, SM Janes, SV Shmelkov, T Hara, T Nikolova, T Reya, WJ Huss, Y Katoh, Y Lu   +82 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

WNT: an unexpected tumor suppressor in medulloblastoma

Molecular & Cellular Oncology, 2020
Medulloblastoma (MB) represents the most common malignant pediatric brain tumor and is defined by four molecular subgroups with WNT MB having the most favorable prognosis. Our work provides a rational therapeutic option in which the protective effects of
Branavan Manoranjan, Ashley A. Adile, Chitra Venugopal, Sheila K. Singh   +3 more
doaj   +1 more source