Integration of SHH and WNT pathways controls morphogenesis of the CNS. [PDF]
, 2008 [eng] Dorsoventral patterning of the vertebrate nervous system is achieved by the combined activity of morphogenetic signals secreted from dorsal and ventral signalling centres. The Shh/Gli pathway plays a major role in patterning the ventral neural tube;
Álvarez Medina, José Roberto
core +3 more sources
Differentiation of the brain vasculature : the answer came blowing by the Wnt [PDF]
, 2010 Vascularization of the vertebrate brain takes place during embryonic development from a preformed perineural vascular plexus. As a consequence of the intimate contact with neuroectodermal cells the vessels, which are entering the brain exclusively via ...
Liebner, Stefan +3 more
core +1 more source
Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled [PDF]
Open Biology, 2015 Dishevelled is a pivot in Wnt signal transduction, controlling both β-catenin-dependent transcription to specify proliferative cell fates, and cell polarity and other non-nuclear events in post-mitotic cells.
Thomas Mund +5 more
doaj +1 more source
Dissecting the roles of WNT signaling in breast cancer using "in vitro" and "in vivo" experimental models [PDF]
, 2009 Canonical WNT pathway regulates expression of target genes by modulating intracellular amount of β-catenin. Without WNT pathway activation, a so-called “destruction complex” including APC and Axin facilitates the degradation of β-catenin. Upon binding of
Matsuda, Yutaka
core +1 more source
Prostate cancer stem cell fate: β-catenin and the Wnt pathway [PDF]
, 2010 A major problem in prostate cancer is the high relapse rate post therapy. This is believed to be due to the presence of a small number of prostate cancer stem cells within a tumour.
Jakoby, Sarah
core +4 more sources
Morphogenesis and axis specification occur in parallel during optic cup and optic fissure formation, differentially modulated by BMP and Wnt [PDF]
Open Biology, 2019 Optic cup morphogenesis is an intricate process. Especially, the formation of the optic fissure is not well understood. Persisting optic fissures, termed coloboma, are frequent causes for congenital blindness.
Priska Eckert +4 more
doaj +1 more source
Maternal Wnt/β-catenin signaling coactivates transcription through NF-κB binding sites during Xenopus axis formation. [PDF]
, 2012 Maternal Wnt/β-Catenin signaling establishes a program of dorsal-specific gene expression required for axial patterning in Xenopus. We previously reported that a subset of dorsally expressed genes depends not only on Wnt/β-Catenin stimulation, but also ...
Rupp, Ralph A. W. +11 more
core +2 more sources
Canonical WNT pathway inhibition reduces ATP synthesis rates in glioblastoma stem cells
Frontiers in Bioscience-Landmark, 2022 Background: The conserved stem cell signaling network canonical Wingless (WNT) plays important roles in development and disease. Aberrant activation of this pathway has been linked to tumor progression and resistance to therapy.
Dymphna Margriet Ouwens +12 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Stimulation of epidermal hyperplasia and tumorigenesis by resident p16INK4a-expressing cells
Molecular & Cellular Oncology, 2020 p16INK4a (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16INK4a in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes.
Narmen Azazmeh, Ittai Ben-Porath
doaj +1 more source