Results 1 to 10 of about 100,766 (120)

Proteome Profile of Myelin in the Zebrafish Brain

Frontiers in Cell and Developmental Biology, 2021
The velocity of nerve conduction along vertebrate axons depends on their ensheathment with myelin. Myelin membranes comprise specialized proteins well characterized in mice.
Sophie B. Siems, Olaf Jahn, Laura J. Hoodless, Ramona B. Jung, Dörte Hesse, Wiebke Möbius, Wiebke Möbius, Tim Czopka, Hauke B. Werner   +8 more
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Proteome mapping of adult zebrafish marrow neutrophils reveals partial cross species conservation to human peripheral neutrophils. [PDF]

PLoS ONE, 2013
Neutrophil granulocytes are pivotal cells within the first line of host defense of the innate immune system. In this study, we have used a gel-based LC-MS/MS approach to explore the proteome of primary marrow neutrophils from adult zebrafish.
Sachin Kumar Singh, Sachin Sethi, Sriram Aravamudhan, Marcus Krüger, Clemens Grabher   +4 more
doaj   +1 more source

Zebrafish mbnl mutants model physical and molecular phenotypes of myotonic dystrophy

Disease Models & Mechanisms, 2021
The muscleblind RNA-binding proteins (MBNL1, MBNL2 and MBNL3) are highly conserved across vertebrates and are important regulators of RNA alternative splicing.
Melissa N. Hinman, Jared I. Richardson, Rose A. Sockol, Eliza D. Aronson, Sarah J. Stednitz, Katrina N. Murray, J. Andrew Berglund, Karen Guillemin   +7 more
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Inactivation of ca10a and ca10b Genes Leads to Abnormal Embryonic Development and Alters Movement Pattern in Zebrafish. [PDF]

PLoS ONE, 2015
Carbonic anhydrase related proteins (CARPs) X and XI are highly conserved across species and are predominantly expressed in neural tissues. The biological role of these proteins is still an enigma.
Ashok Aspatwar, Martti E E Tolvanen, Markus J T Ojanen, Harlan R Barker, Anni K Saralahti, Carina A Bäuerlein, Csaba Ortutay, Peiwen Pan, Marianne Kuuslahti, Mataleena Parikka, Mika Rämet, Seppo Parkkila   +11 more
doaj   +1 more source

Insights Into the Peroxisomal Protein Inventory of Zebrafish

Frontiers in Physiology, 2022
Peroxisomes are ubiquitous, oxidative subcellular organelles with important functions in cellular lipid metabolism and redox homeostasis. Loss of peroxisomal functions causes severe disorders with developmental and neurological abnormalities.
Maki Kamoshita, Rechal Kumar, Marco Anteghini, Marco Anteghini, Markus Kunze, Markus Islinger, Vítor Martins dos Santos, Vítor Martins dos Santos, Michael Schrader   +8 more
doaj   +1 more source

Screening of Tnfaip1-Interacting Proteins in Zebrafish Embryonic cDNA Libraries Using a Yeast Two-Hybrid System

Current Issues in Molecular Biology, 2023
TNFAIP1 regulates cellular biological functions, including DNA replication, DNA repair, and cell cycle, by binding to target proteins. Identification of Tnfaip1-interacting proteins contributes to the understanding of the molecular regulatory mechanisms ...
Shulan Huang, Hongning Zhang, Wen Chen, Jiawei Wang, Zhen Wu, Meiqi He, Jian Zhang, Xiang Hu, Shuanglin Xiang   +8 more
doaj   +1 more source

Degradation of endogenous proteins and generation of a null-like phenotype in zebrafish using Trim-Away technology

Genome Biology, 2019
Trim-Away is a recent technique to rapidly deplete a protein from any cell type. Guided by antibodies, TRIM21 selects proteins for destruction. However, the applicability of this method in model organisms has not been investigated.
Xiao Chen, Mi Liu, Hongyan Lou, Yiyi Lu, Meng-Tao Zhou, Rongying Ou, Yunsheng Xu, Kai-Fu Tang   +7 more
doaj   +1 more source

Authentication of a novel antibody to zebrafish collagen type XI alpha 1 chain (Col11a1a)

BMC Research Notes, 2021
Objective Extracellular matrix proteins play important roles in embryonic development and antibodies that specifically detect these proteins are essential to understanding their function. The zebrafish embryo is a popular model for vertebrate development
Jonathon C. Reeck, Makenna J. Hardy, Xinzhu Pu, Cynthia Keller-Peck, Julia Thom Oxford   +4 more
doaj   +1 more source

zGrad is a nanobody-based degron system that inactivates proteins in zebrafish

eLife, 2019
The analysis of protein function is essential to modern biology. While protein function has mostly been studied through gene or RNA interference, more recent approaches to degrade proteins directly have been developed.
Naoya Yamaguchi, Tugba Colak-Champollion, Holger Knaut   +2 more
doaj   +1 more source

Comparative Morphological, Metabolic and Transcriptome Analyses in elmo1−/−, elmo2−/−, and elmo3−/− Zebrafish Mutants Identified a Functional Non-Redundancy of the Elmo Proteins

Frontiers in Cell and Developmental Biology, 2022
The ELMO protein family consists of the homologues ELMO1, ELMO2 and ELMO3. Several studies have shown that the individual ELMO proteins are involved in a variety of cellular and developmental processes.
Mike Boger, Katrin Bennewitz, David Philipp Wohlfart, Ingrid Hausser, Carsten Sticht, Gernot Poschet, Jens Kroll   +6 more
doaj   +1 more source