Results 41 to 50 of about 101,248 (263)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Epigenetic regulation in zebrafish development: the roles of polycomb group proteins in heart and pectoral fin development

Epigenetics Communications
Background Polycomb group proteins, known for their role in epigenetic gene silencing, are critical regulators of cell fate and tissue development across species.
Pratiksha S. Kavade, Saili S. Parab, Vincenza Capone, Daniela Carannante, Concetta Ambrosino, Lucia Altucci, Vincenzo Carafa   +6 more
doaj   +1 more source

trappc11is required for protein glycosylation in zebrafish and humans

Molecular Biology of the Cell, 2016
Activation of the unfolded protein response (UPR) can be either adaptive or pathological. We term the pathological UPR that causes fatty liver disease a “stressed UPR.” Here we investigate the mechanism of stressed UPR activation in zebrafish bearing a mutation in the trappc11 gene, which encodes a component of the transport protein particle (TRAPP ...
DeRossi, Charles, Vacaru, Ana, Rafiq, Ruhina, Cinaroglu, Ayca, Imrie, Dru, Nayar, Shikha, Baryshnikova, Anastasia, Milev, Miroslav P., Stanga, Daniela, Kadakia, Dhara, Gao, Ningguo, Chu, Jaime, Freeze, Hudson H., Lehrman, Mark A., Sacher, Michael, Sadler, Kirsten C.   +15 more
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish

Communications Biology, 2022
The role of sperm membrane proteins DCST1 and DCST2 in gamete fusion is extended to zebrafish in showing that these interdependent proteins are required for sperm-egg binding.
Taichi Noda, Andreas Blaha, Yoshitaka Fujihara, Krista R. Gert, Chihiro Emori, Victoria E. Deneke, Seiya Oura, Karin Panser, Yonggang Lu, Sara Berent, Mayo Kodani, Luis Enrique Cabrera-Quio, Andrea Pauli, Masahito Ikawa   +13 more
doaj   +1 more source

A ligand-receptor interactome atlas of the zebrafish

iScience, 2023
Summary: Studies in zebrafish can unravel the functions of cellular communication and thus identify novel bench-to-bedside drugs targeting cellular communication signaling molecules.
Milosz Chodkowski, Andrzej Zielezinski, Savani Anbalagan   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The cobalamin-binding protein in zebrafish is an intermediate between the three cobalamin-binding proteins in human.

PLoS ONE, 2012
In humans, three soluble extracellular cobalamin-binding proteins; transcobalamin (TC), intrinsic factor (IF), and haptocorrin (HC), are involved in the uptake and transport of cobalamin.
Eva Greibe, Sergey Fedosov, Ebba Nexo
doaj   +1 more source

Meis family proteins are required for hindbrain development in the zebrafish [PDF]

Development, 2002
Meis homeodomain proteins function as Hox-cofactors by binding Pbx and Hox proteins to form multimeric complexes that control transcription of genes involved in development and differentiation. It is not known what role Meis proteins play in these complexes, nor is it clear which Hox functions require Meis proteins in vivo. We now show that a divergent
Seong-Kyu, Choe, Vlachakis, Nikolaos, Sagerstrom, Charles G.   +2 more
openaire   +3 more sources

Detection of Zebrafish Retinal Proteins by Infrared Western Blotting

BIO-PROTOCOL, 2023
The zebrafish retina is a canonical vertebrate retina. Since the past few years, with the continually growing genetic toolbox and imaging techniques, zebrafish plays a crucial role in retinal research. This protocol describes a method to quantitatively evaluate the expression of Arrestin3a (Arr3a) and G-protein receptor kinase7a (Grk7a) in the adult ...
Zang, Jingjing, Neuhauss, Stephan C F
openaire   +4 more sources