β-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation. [PDF]
PLoS ONE, 2014 β-Catenin independent, non-canonical Wnt signaling pathways play a major role in the regulation of morphogenetic movements in vertebrates. The term non-canonical Wnt signaling comprises multiple, intracellularly divergent, Wnt-activated and β-Catenin ...
Katharina Seitz +5 more
doaj +3 more sources
Wnt Signaling Translocates Lys48-Linked Polyubiquitinated Proteins to the Lysosomal Pathway [PDF]
Cell Reports, 2015 Cellular proteins are degraded in either proteasomes or lysosomes depending on the types of ubiquitin chains that covalently modify them. It is not known whether the choice between these two pathways is physiologically regulated.
Hyunjoon Kim +4 more
doaj +2 more sources
A Protein Disulfide Isomerase Controls Neuronal Migration through Regulation of Wnt Secretion
Cell Reports, 2019 Summary: Appropriate Wnt morphogen secretion is required to control animal development and homeostasis. Although correct Wnt globular structure is essential for secretion, proteins that directly mediate Wnt folding and maturation remain uncharacterized ...
Nanna Torpe +6 more
doaj +3 more sources
Genome-Wide Identification and Characterization of the Wnt Gene Family in Donkey (Equus asinus): Phylogenetic Analysis and Expression Profiling [PDF]
BiologyThe Wnt gene family encodes highly conserved signaling molecules involved in vertebrate development, tissue homeostasis, and cell fate regulation. However, the evolutionary characteristics and potential biological functions of Wnt genes in the domestic ...
Qifei Zhu +6 more
doaj +2 more sources
The role of Sfrp and DKK proteins in cardiomyocyte development
Physiological Reports, 2021 In this review, we summarize the role of Wnt proteins in cardiomyogenesis. More specifically, we focus on how the development of cardiomyocytes from precursor cells involves a complex interplay between Wnt canonical β‐catenin signaling pathways and Wnt ...
Ying‐Chang Hsueh +2 more
doaj +1 more source
Targets of Wnt/ß-catenin transcription in penile carcinoma. [PDF]
PLoS ONE, 2015 Penile squamous cell carcinoma (PeCa) is a rare malignancy and little is known regarding the molecular mechanisms involved in carcinogenesis of PeCa. The Wnt signaling pathway, with the transcription activator ß-catenin as a major transducer, is a key ...
Manit Arya +11 more
doaj +1 more source
Role of Wnt Signaling in Mouse Fetal Skin Wound Healing
Biomedicines, 2022 Wnt proteins secrete glycoproteins that are involved in various cellular processes to maintain homeostasis during development and adulthood. However, the expression and role of Wnt in wound healing have not been fully documented.
Kento Takaya +7 more
doaj +1 more source
Frontiers in Genetics, 2021 The Wnt signaling pathway is an evolutionarily conserved signaling pathway that plays essential roles in embryonic development, organogenesis, and many other biological activities.
Zhongchao Gai +4 more
doaj +1 more source
Wnt signalling pathway parameters for mammalian cells. [PDF]
PLoS ONE, 2012 Wnt/β-catenin signalling regulates cell fate, survival, proliferation and differentiation at many stages of mammalian development and pathology. Mutations of two key proteins in the pathway, APC and β-catenin, have been implicated in a range of cancers ...
Chin Wee Tan +5 more
doaj +1 more source
Canonical Wnt signaling induces focal adhesion and Integrin beta-1 endocytosis
iScience, 2022 Summary: During canonical Wnt signaling, the Wnt receptor complex is sequestered together with glycogen synthase kinase 3 (GSK3) and Axin inside late endosomes, known as multivesicular bodies (MVBs).
Nydia Tejeda-Muñoz +5 more
doaj +1 more source