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Bioinformatic Analysis of WNT Family Proteins
Bioinformatics and Biology InsightsWNT proteins constitute a highly conserved family of signaling molecules that play an important role in regulating embryonic development and maintaining adult tissue homeostasis.
Konstantin Midlovets +2 more
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Cold Spring Harb Perspect Biol, 2012 Wnt proteins comprise a major family of signaling molecules that orchestrate and influence a myriad of cell biological and developmental processes. Although our understanding of the role of Wnt signaling in regulating development and affecting disease, such as cancer, has been ever increasing, the study of the Wnt proteins themselves has been ...
Willert K, Nusse R.
europepmc +4 more sources
β-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation. [PDF]
PLoS ONE, 2014 β-Catenin independent, non-canonical Wnt signaling pathways play a major role in the regulation of morphogenetic movements in vertebrates. The term non-canonical Wnt signaling comprises multiple, intracellularly divergent, Wnt-activated and β-Catenin ...
Katharina Seitz +5 more
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The role of Evi/Wntless in exporting Wnt proteins.
Development, 2023 ABSTRACTIntercellular communication by Wnt proteins governs many essential processes during development, tissue homeostasis and disease in all metazoans. Many context-dependent effects are initiated in the Wnt-producing cells and depend on the export of lipidated Wnt proteins.
Wolf L, Boutros M.
europepmc +3 more sources
Wnt proteins as modulators of synaptic plasticity.
Curr Opin Neurobiol, 2018 Dynamic changes in the structure and function of synapses in response to the environment, termed synaptic plasticity, are the cellular basis of learning and memory. At excitatory synapses, activation of NMDA receptors by glutamate leads to calcium influx triggering intracellular pathways that promote the trafficking of AMPA receptors to the post ...
McLeod F, Salinas PC.
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Differences in the secretion and transport of Wnt proteins [PDF]
Journal of Biochemistry, 2017 During the last three decades, our understanding about Wnt signaling has progressed greatly, especially with regards to the molecular mechanism of intracellular transmission of this signaling, as well as its physiological roles. In parallel, the molecular nature of Wnt proteins has gradually but surely been clarified.
Ritsuko Takada +2 more
exaly +3 more sources
The role of Sfrp and DKK proteins in cardiomyocyte development
Physiological Reports, 2021 In this review, we summarize the role of Wnt proteins in cardiomyogenesis. More specifically, we focus on how the development of cardiomyocytes from precursor cells involves a complex interplay between Wnt canonical β‐catenin signaling pathways and Wnt ...
Ying‐Chang Hsueh +2 more
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Targets of Wnt/ß-catenin transcription in penile carcinoma. [PDF]
PLoS ONE, 2015 Penile squamous cell carcinoma (PeCa) is a rare malignancy and little is known regarding the molecular mechanisms involved in carcinogenesis of PeCa. The Wnt signaling pathway, with the transcription activator ß-catenin as a major transducer, is a key ...
Manit Arya +11 more
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Role of Wnt Signaling in Mouse Fetal Skin Wound Healing
Biomedicines, 2022 Wnt proteins secrete glycoproteins that are involved in various cellular processes to maintain homeostasis during development and adulthood. However, the expression and role of Wnt in wound healing have not been fully documented.
Kento Takaya +7 more
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Frontiers in Genetics, 2021 The Wnt signaling pathway is an evolutionarily conserved signaling pathway that plays essential roles in embryonic development, organogenesis, and many other biological activities.
Zhongchao Gai +4 more
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