Results 1 to 10 of about 16,257 (211)

LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence [PDF]

Frontiers in Cell and Developmental Biology, 2021
The canonical Wnt/β-catenin signaling plays a fundamental role in regulating embryonic development, injury repair and the pathogenesis of human diseases.
Youhua Liu
exaly   +5 more sources

Low density lipoprotein receptor related protein 6 (LRP6) protects heart against oxidative stress by the crosstalk of HSF1 and GSK3β

Redox Biology, 2020
Low density lipoprotein receptor-related protein 6 (LRP6), a Wnt co-receptor, induces multiple functions in various organs. We recently reported cardiac specific LRP6 deficiency caused cardiac dysfunction in mice.
Zhidan Chen, Xiang Wang, Yi Shen
exaly   +3 more sources

LRP6 β-Propeller Destabilization: Novel Variant, Phenotype and Diagnostic Implications in Tooth Agenesis [PDF]

International Dental Journal
: Background and Objectives: Oligodontia, the congenital absence of multiple permanent teeth, is frequently linked to LRP6 variants. However, the genotype–phenotype correlations remain unclear and non-European cohorts are underrepresented.
Narin Intarak, Tohid Ghasemnejad, Kausar Sadia Fakhruddin, Ayaana Kamal, Sasiprapa Prommanee, Khadijeh Hoda Jahanian, Nigel H. Lovell, Hamid Alinejad-Rokny, Thantrira Porntaveetus   +8 more
doaj   +2 more sources

Genotype–phenotype analysis and functional study of three novel LRP6 variants in non-syndromic oligodontia [PDF]

Frontiers in Genetics
Introduction:Tooth agenesis (TA) is a common craniofacial malformation in humans, characterized by the absence of one or more permanent teeth. Recent studies have identified the low-density lipoprotein receptor-related protein 6 (LRP6) gene as an ...
Yunyun Yuan, Ya Zhao, Lingqiang Meng, Shuyun Zheng, Hui Li, Jiabao Ren, Beibei Li, Chenyun Dou, Yan Hou, Wenjing Chen, Jing Zhang, Jing Zhang, Yulin Ding, Yulin Ding, Wenjing Shen   +14 more
doaj   +2 more sources

Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor [PDF]

Nature Communications
Wnt signal transduction relies on the direct inhibition of GSK3 by phosphorylated PPPSPxS motifs within the cytoplasmic tail of the LRP6 co-receptor. How GSK3 is recruited to LRP6 remains unclear.
Melissa V. Gammons, Elsa Franco-Echevarría, Tie-Mei Li, Trevor J. Rutherford, Miha Renko, Christopher Batters, Mariann Bienz   +6 more
doaj   +2 more sources

New insights into Wnt - Lrp5/6 - β-catenin signaling in mechanotransduction [PDF]

Frontiers in Endocrinology, 2015
Mechanical loading is essential to maintain normal bone metabolism and the balance between bone formation and resorption. The cellular mechanisms that control mechanotransduction are not fully defined, but several key pathways have been identified.
Alexander eRobling, Kyung Shin eKang
doaj   +5 more sources

WNT-induced association of Frizzled and LRP6 is not sufficient for the initiation of WNT/β-catenin signaling [PDF]

Nature Communications
The Wingless/Int-1 (WNT) signaling network is essential to orchestrate central physiological processes such as embryonic development and tissue homeostasis.
Jan Hendrik Voss, Zsombor Koszegi, Yining Yan, Emily Shorter, Lukas Grätz, Johanna T. Lanner, Davide Calebiro, Gunnar Schulte   +7 more
doaj   +2 more sources

Novel role for the innate immune receptor toll-like receptor 4 (TLR4) in the regulation of the wnt signaling pathway and photoreceptor apoptosis [PDF]

, 2012
Recent evidence has implicated innate immunity in regulating neuronal survival in the brain during stroke and other neurodegenerations. Photoreceptors are specialized light-detecting neurons in the retina that are essential for vision.
A Poltorak, A Wenzel, Abigail S. Hackam, AK Silva, AL Kindzelskii, Amit K. Patel, AO Edwards, AS Hackam, B Marsh, BJ Marsh, BJ Marsh, C Bowes, C Liu, C Niehrs, C Zhang, Chhinder P. Sodhi, CP Sodhi, CY Logan, D Jiang, David J. Hackam, DJ Kaczorowski, E Cario, E Chaum, E Okun, F Hua, F Limana, G Faraco, G Tezel, GA Limb, GM Seigel, GR Barile, GS Hageman, GT Higgins, H Yi, H Yi, HL Rosenzweig, HL Rosenzweig, HP Scholl, Hyun Yi, IA El-Ghrably, J Merenmies, J Qiu, J Watson, JK Shen, JR Caso, K Hoshino, K Kaarniranta, K Miyake, K Takeda, KP Mollen, L Barandon, L Minghetti, M Mizukami, MA Fragoso, Mauricio Martins Rodrigues, MD Gordon, MK Ko, MT Lotze, N Arimura, P Matzinger, PJ Franco, PY Leung, Q Xing, R Gauthier, R Gorina, R Kacimi, R Seitz, R Shechter, RM Vabulas, RR Caspi, RT Moon, S Lehnardt, S Lin, S Tell, S Walter, S Zareparsi, SC Gribar, SC Tang, SC Tang, SR Coats, T Ha, T Harada, T Harada, T Nakazawa, U Kilic, V Bocchini, V Fontaine, Y de Kozak, Y Xin, Z Tu   +89 more
core   +16 more sources

IUGR with catch-up growth programs impaired insulin sensitivity through LRP6/IRS-1 in male rats

Endocrine Connections, 2022
Intrauterine growth restriction combined with postnatal accelerated growth (CG-IUGR) could lead to long-term detrimental metabolic outcomes characte rized by insulin resistance.
Wenjun Long, Tuo Zhou, Xiuping Xuan, Qiuli Cao, Zuojie Luo, Yingfen Qin, Qin Ning, Xiaoping Luo, Xuemei Xie   +8 more
doaj   +1 more source

The role of Lrp6-mediated Wnt/β-catenin signaling in the development and intervention of spinal neural tube defects in mice

Disease Models & Mechanisms, 2022
Neural tube defects (NTDs) are among the common and severe birth defects with poorly understood etiology. Mutations in the Wnt co-receptor LRP6 are associated with NTDs in humans.
Tianyu Zhao, Moira McMahon, Kurt Reynolds, Subbroto Kumar Saha, Arjun Stokes, Chengji J. Zhou   +5 more
doaj   +1 more source