Results 11 to 20 of about 16,257 (211)
LRP6-mediated phosphorylation of connexin43 in myocardial infarction
iScience, 2023 Summary: Ventricular tachycardia (VT) and ventricular fibrillation are most causes of early death in patients with acute myocardial infarction (AMI). Conditional cardiac-specific low-density lipoprotein receptor-related protein 6 (LRP6)-knockout mice ...
Xu-min Zhang +4 more
doaj +3 more sources
Dkk1 stabilizes Wnt co-receptor LRP6: implication for Wnt ligand-induced LRP6 down-regulation.
PLoS ONE, 2010 BackgroundThe low density lipoprotein receptor-related protein-6 (LRP6) is an essential co-receptor for canonical Wnt signaling. Dickkopf 1 (Dkk1), a major secreted Wnt signaling antagonist, binds to LRP6 with high affinity and prevents the Frizzled-Wnt ...
Yonghe Li +5 more
doaj +4 more sources
Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6. [PDF]
PLoS ONE, 2011 Low-density lipoprotein receptor-related proteins 5 and 6 (LRP5 and LRP6) serve as Wnt co-receptors for the canonical β-catenin pathway. While LRP6 is essential for embryogenesis, both LRP5 and LRP6 play critical roles for skeletal remodeling ...
Bryan T MacDonald +3 more
doaj +4 more sources
Targeting LRP6: A new strategy for cancer therapy
Pharmacological ResearchTargeting specific molecular drivers of tumor growth is a key approach in cancer therapy. Among these targets, the low-density lipoprotein receptor-related protein 6 (LRP6), a vital component of the Wnt signaling pathway, has emerged as an intriguing ...
Wei Xue +7 more
doaj +3 more sources
RAB8B Is Required for Activity and Caveolar Endocytosis of LRP6
Cell Reports, 2013 Wnt/β-catenin signaling plays an important role in embryonic development and adult tissue homeostasis. When Wnt ligands bind to the receptor complex, LRP5/6 coreceptors are activated by phosphorylation and concomitantly endocytosed.
Kubilay Demir +9 more
doaj +5 more sources
TIMP2 promotes AKI-CKD transition by inducing tubular maladaptive repair and cell senescence via targeting Wnt/β-catenin signalling. [PDF]
Clin Transl Med1. TIMP2 is upregulated in injured renal tubules and promotes maladaptive repair and cell senescence. 2. Genetic deletion of TIMP2 in tubular epithelial cells attenuates renal fibrosis and improves mitochondrial function. 3. TIMP2 activates Wnt/β‐catenin signalling by binding to LRP6 via an MMP‐independent mechanism.
Xu D +6 more
europepmc +2 more sources
Rare phenotype: Hand preaxial polydactyly associated with LRP6-related tooth agenesis in humans
npj Genomic Medicine, 2021 Low-density lipoprotein receptor-related protein 6 (LRP6) is a pathogenic gene of selective tooth agenesis-7 (OMIM#616724). Although the malformation of the digits and fore- and hindlimbs has been reported in Lrp6-deficient mice, it has been rarely ...
Liutao Zhang +7 more
doaj +1 more source
Novel LRP6 Mutations Causing Non-Syndromic Oligodontia
Journal of Personalized Medicine, 2022 The process of tooth formation is a series of reciprocal interactions between the ectoderm and mesoderm, and it is believed that many genetic factors are involved in this complex process. More than a dozen genes have been identified in non-syndromic tooth agenesis; however, the genetic etiology underlying tooth agenesis is not fully understood yet.
Yejin Lee +3 more
openaire +2 more sources
The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development. [PDF]
PLoS ONE, 2009 Canonical Wnt signals are transduced through a Frizzled receptor and either the LRP5 or LRP6 co-receptor; such signals play central roles during development and in disease.
Charlotta Lindvall +6 more
doaj +1 more source
Oxidized phospholipids are ligands for LRP6 [PDF]
Bone Research, 2018 AbstractLow-density lipoprotein receptor–related protein 6 (LRP6) is a co-receptor for Wnt signaling and can be recruited by multiple growth factors/hormones to their receptors facilitating intracellular signaling activation. The ligands that bind directly to LRP6 have not been identified.
Wang, Lei +11 more
openaire +2 more sources