Results 1 to 10 of about 40,337 (298)
New insights into Wnt - Lrp5/6 - β-catenin signaling in mechanotransduction
Frontiers in Endocrinology, 2015 Mechanical loading is essential to maintain normal bone metabolism and the balance between bone formation and resorption. The cellular mechanisms that control mechanotransduction are not fully defined, but several key pathways have been identified.
Alexander eRobling, Kyung Shin eKang
doaj +1 more source
Osteoarthritis and Cartilage Open, 2022 Objective: Exercise is known to induce beneficial effects in synovial joints. However, the mechanisms underlying these are unclear. Synovial joints experience repeated mechanical loading during exercise.
Alyssa K. Hahn +5 more
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Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymphatic Expansion
Circulation Research, 2022 Background: Mutations in PIEZO1 (Piezo type mechanosensitive ion channel component 1) cause human lymphatic malformations. We have previously uncovered an ORAI1 (ORAI calcium release-activated calcium modulator 1)-mediated mechanotransduction pathway ...
Dongwon Choi +24 more
semanticscholar +1 more source
Innovative Tools for Mechanobiology: Unraveling Outside-In and Inside-Out Mechanotransduction
Frontiers in Bioengineering and Biotechnology, 2019 Cells and tissues can sense and react to the modifications of the physico-chemical properties of the extracellular environment (ECM) through integrin-based adhesion sites and adapt their physiological response in a process called mechanotransduction. Due
Danahe Mohammed +8 more
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Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms.
Annual Review of Neuroscience, 2020 Activation of mechanosensitive ion channels underlies a variety of fundamental physiological processes that require sensation of mechanical force. Different mechanosensitive channels adapt distinctive structures and mechanotransduction mechanisms to fit ...
P. Jin, L. Jan, Y. Jan
semanticscholar +1 more source
Rat Merkel cells are mechanoreceptors and osmoreceptors. [PDF]
PLoS ONE, 2009 Merkel cells (MCs) associated with nerve terminals constitute MC-neurite complexes, which are involved in slowly-adapting type I mechanoreception. Although MCs are known to express voltage-gated Ca2+ channels and hypotonic-induced membrane deformation is
Nicholas Boulais +7 more
doaj +1 more source
Extracellular Matrix Cues Regulate Mechanosensing and Mechanotransduction of Cancer Cells
CellsExtracellular biophysical properties have particular implications for a wide spectrum of cellular behaviors and functions, including growth, motility, differentiation, apoptosis, gene expression, cell–matrix and cell–cell adhesion, and signal ...
C. Mierke
semanticscholar +1 more source
Cancer Cell, 2019 Integrins mediate cell adhesion and transmit mechanical and chemical signals to the cell interior. Various mechanisms deregulate integrin signaling in cancer, empowering tumor cells with the ability to proliferate without restraint, to invade through ...
Jonathan M Cooper, F. Giancotti
semanticscholar +1 more source
Mechanotransduction in Mesenchymal Stem Cells (MSCs) Differentiation: A Review
International Journal of Molecular Sciences, 2022 Mechanotransduction is the process by which physical force is converted into a biochemical signal that is used in development and physiology; meanwhile, it is intended for the ability of cells to sense and respond to mechanical forces by activating ...
Narmadaa Raman +4 more
semanticscholar +1 more source
Cellular Mechanotransduction: From Tension to Function
Frontiers in Physiology, 2018 Living cells are constantly exposed to mechanical stimuli arising from the surrounding extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes through which such physical cues are transformed into a biological response
Fabiana Martino +4 more
semanticscholar +1 more source