Results 1 to 10 of about 30,024 (214)

The role of ECM mechanics in cancer mechanotransduction through unraveling the molecular machinery of integrins, FAK, and YAP signaling [PDF]

Cellular & Molecular Biology Letters
Mechanotransduction, the process by which cells convert mechanical stimuli into biochemical signals, is fundamental for maintaining tissue homeostasis and regulating physiological functions. The extracellular matrix (ECM) serves as a critical mediator of
Nourhan Hassan, Burkhard Greve, Martin Götte   +2 more
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A Hierarchical Mechanotransduction System: From Macro to Micro

Advanced Science
Mechanotransduction is a strictly regulated process whereby mechanical stimuli, including mechanical forces and properties, are sensed and translated into biochemical signals. Increasing data demonstrate that mechanotransduction is crucial for regulating
Xianghui Fu
exaly   +2 more sources

Endothelial CD44 cleavage by ADAM17 impairs shear stress mechanotransduction [PDF]

Function
In individuals with type 2 diabetes (T2D), blood flow-mediated increases in endothelial shear stress fail to elicit a robust vasodilatory response. This defective flow-mediated dilation (FMD) is associated with loss of the endothelial glycocalyx, a ...
Gavin Power, Min Jeong Cho, Jesus H. Beltran-Ornelas, Marc A. Augenreich, Natnicha Imkaew, Olubodun M. Lateef, Francisco I. Ramirez-Perez, Larissa Ferreira-Santos, Camila Manrique-Acevedo, Luis A. Martinez-Lemus, Jaume Padilla   +10 more
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Tumor microenvironment and mechanotransduction pathways: Novel targets and new directions for cancer therapy [PDF]

Mechanobiology in Medicine
In cancer research, the extracellular matrix (ECM) of the tumor microenvironment (TME) was once regarded as a mere passive structural scaffold for tumor tissue, while the biomechanical cues generated by its dynamic physical remodeling have now emerged as
Xinjie Zhang, Jian Sun, Zhengjian Li, Shaowei Wang   +3 more
doaj   +2 more sources

Lamins’ role in osteosarcoma [PDF]

Frontiers in Cell and Developmental Biology
Osteosarcoma (OS) is a rare and highly aggressive bone tumor that can develop in several skeletal segments, although it predominantly affects the long bones. This cancer mostly occurs in adolescents, young adults and people older than 60.
Giulia Bagnato, Giulia Bagnato, Barbara Peruzzi, Barbara Peruzzi   +3 more
doaj   +2 more sources

The Mechanotransduction Channel and Organic Cation Transporter Are Critical for Cisplatin Ototoxicity in Murine Hair Cells

Frontiers in Molecular Neuroscience, 2022
Cisplatin is one of the most widely used chemotherapeutic drugs across the world. However, the serious ototoxic effects, leading to permanent hair cell death and hearing loss, significantly limit the utility of cisplatin.
Jinan Li, Chang Liu, Samuel Kaefer, Mariam Youssef, Bo Zhao   +4 more
doaj   +1 more source

The role of osteocytes-specific molecular mechanism in regulation of mechanotransduction – A systematic review

Journal of Orthopaedic Translation, 2021
Background: Osteocytes, composing over 90% of bone cells, are well known for their mechanosensing abilities. Aged osteocytes with impaired morphology and function are less efficient in mechanotransduction which will disrupt bone turnover leading to ...
Meng Chen Michelle Li, Simon Kwoon Ho Chow, Ronald Man Yeung Wong, Ling Qin, Wing Hoi Cheung   +4 more
doaj   +1 more source

Response to mechanical stress is mediated by the TRPA channel painless in the Drosophila heart. [PDF]

PLoS Genetics, 2010
Mechanotransduction modulates cellular functions as diverse as migration, proliferation, differentiation, and apoptosis. It is crucial for organ development and homeostasis and leads to pathologies when defective.
Sébastien Sénatore, Vatrapu Rami Reddy, Michel Sémériva, Laurent Perrin, Nathalie Lalevée   +4 more
doaj   +1 more source

Mechanical properties of the brain: Focus on the essential role of Piezo1‐mediated mechanotransduction in the CNS

Brain and Behavior, 2023
Background The brain is a highly mechanosensitive organ, and changes in the mechanical properties of brain tissue influence many physiological and pathological processes.
Qingcui Zheng, Hailin Liu, Wen Yu, Yao Dong, Lanqian Zhou, Wenze Deng, Fuzhou Hua   +6 more
doaj   +1 more source

A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes

Biophysical Reports, 2021
Mechanotransduction at focal adhesion complexes is key for various cellular events. Theoretical analyses were performed to predict a potential role of lipid membranes in modulating mechanotransduction at focal adhesions.
Jichul Kim
doaj   +1 more source