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Mechanotransduction in Skin Inflammation
Cells, 2022 In the process of mechanotransduction, the cells in the body perceive and interpret mechanical stimuli to maintain tissue homeostasis and respond to the environmental changes.
Maria S. Shutova, Wolf-Henning Boehncke
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Extracellular mechanotransduction [PDF]
Journal of General Physiology, 2022 We highlight the force-sensing function of extracellular matrix and present a complementary mechanotransduction paradigm.
Haller, Stephen J., Dudley, Andrew T.
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Biophysics of Mechanotransduction [PDF]
European Biophysics Journal, 2015 (Singer and Nicolson 1972). As a physical barrier it presents a major target of mechanical forces stretching, compressing, bending or even breaking it, if an excessive force is acting on it. As a composite of a large variety of lipid molecules such as phospholipids, sphingolipids, cholesterol and many others, the lipid bilayer of the cell membrane ...
Boris, Martinac, Andrew R, Battle
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Mechanotransduction in osteogenesis
Bone and Joint Research, 2020 Bone is one of the most highly adaptive tissues in the body, possessing the capability to alter its morphology and function in response to stimuli in its surrounding environment. The ability of bone to sense and convert external mechanical stimuli into a biochemical response, which ultimately alters the phenotype and function of the cell, is described ...
Spyros D Masouros +2 more
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A Hierarchical Mechanotransduction System: From Macro to Micro
Advanced ScienceMechanotransduction is a strictly regulated process whereby mechanical stimuli, including mechanical forces and properties, are sensed and translated into biochemical signals. Increasing data demonstrate that mechanotransduction is crucial for regulating
Xianghui Fu
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Integrin-mediated mechanotransduction [PDF]
Journal of Cell Biology, 2016 Cells can detect and react to the biophysical properties of the extracellular environment through integrin-based adhesion sites and adapt to the extracellular milieu in a process called mechanotransduction. At these adhesion sites, integrins connect the extracellular matrix (ECM) with the F-actin cytoskeleton and transduce mechanical forces generated ...
Zhiqi Sun +2 more
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Mechanotransduction gone awry [PDF]
Nature Reviews Molecular Cell Biology, 2009 Cells sense their physical surroundings through mechanotransduction - that is, by translating mechanical forces and deformations into biochemical signals such as changes in intracellular calcium concentration or by activating diverse signalling pathways. In turn, these signals can adjust cellular and extracellular structure.
Diana E Jaalouk +2 more
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Periodontal cell mechanotransduction [PDF]
Open Biology, 2018 The periodontium is a structurally and functionally complex tissue that facilitates the anchorage of teeth in jaws. The periodontium consists of various cell types including stem cells, fibroblasts and epithelial cells.
Sasanka S. Chukkapalli, Tanmay P. Lele
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Endothelial CD44 cleavage by ADAM17 impairs shear stress mechanotransduction [PDF]
FunctionIn individuals with type 2 diabetes (T2D), blood flow-mediated increases in endothelial shear stress fail to elicit a robust vasodilatory response. This defective flow-mediated dilation (FMD) is associated with loss of the endothelial glycocalyx, a ...
Gavin Power +10 more
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