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The role of ECM mechanics in cancer mechanotransduction through unraveling the molecular machinery of integrins, FAK, and YAP signaling [PDF]
Cellular & Molecular Biology LettersMechanotransduction, the process by which cells convert mechanical stimuli into biochemical signals, is fundamental for maintaining tissue homeostasis and regulating physiological functions. The extracellular matrix (ECM) serves as a critical mediator of
Nourhan Hassan +2 more
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A Hierarchical Mechanotransduction System: From Macro to Micro
Advanced ScienceMechanotransduction is a strictly regulated process whereby mechanical stimuli, including mechanical forces and properties, are sensed and translated into biochemical signals. Increasing data demonstrate that mechanotransduction is crucial for regulating
Xianghui Fu
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Frontiers in Molecular Neuroscience, 2022 Cisplatin is one of the most widely used chemotherapeutic drugs across the world. However, the serious ototoxic effects, leading to permanent hair cell death and hearing loss, significantly limit the utility of cisplatin.
Jinan Li +4 more
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Journal of Orthopaedic Translation, 2021 Background: Osteocytes, composing over 90% of bone cells, are well known for their mechanosensing abilities. Aged osteocytes with impaired morphology and function are less efficient in mechanotransduction which will disrupt bone turnover leading to ...
Meng Chen Michelle Li +4 more
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Response to mechanical stress is mediated by the TRPA channel painless in the Drosophila heart. [PDF]
PLoS Genetics, 2010 Mechanotransduction modulates cellular functions as diverse as migration, proliferation, differentiation, and apoptosis. It is crucial for organ development and homeostasis and leads to pathologies when defective.
Sébastien Sénatore +4 more
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A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes
Biophysical Reports, 2021 Mechanotransduction at focal adhesion complexes is key for various cellular events. Theoretical analyses were performed to predict a potential role of lipid membranes in modulating mechanotransduction at focal adhesions.
Jichul Kim
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Brain and Behavior, 2023 Background The brain is a highly mechanosensitive organ, and changes in the mechanical properties of brain tissue influence many physiological and pathological processes.
Qingcui Zheng +6 more
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Mechanotransduction in Skin Inflammation
Cells, 2022 In the process of mechanotransduction, the cells in the body perceive and interpret mechanical stimuli to maintain tissue homeostasis and respond to the environmental changes.
Maria S. Shutova, Wolf-Henning Boehncke
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Mechanotransduction pathways in articular chondrocytes and the emerging role of estrogen receptor-α
Bone Research, 2023 In the synovial joint, mechanical force creates an important signal that influences chondrocyte behavior. The conversion of mechanical signals into biochemical cues relies on different elements in mechanotransduction pathways and culminates in changes in
Ning Wang +8 more
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Mechanotransduction Activity Facilitates Hair Cell Toxicity Caused by the Heavy Metal Cadmium
Frontiers in Cellular Neuroscience, 2020 Hair cells are sensitive to many insults including environmental toxins such as heavy metals. We show here that cadmium can consistently kill hair cells of the zebrafish lateral line.
Caleigh Schmid +4 more
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