Results 11 to 20 of about 41,911 (157)

Extracellular mechanotransduction [PDF]

, 2022
We highlight the force-sensing function of extracellular matrix and present a complementary mechanotransduction ...
Stephen J. Haller, Dudley, Andrew T., Haller, Stephen J., Andrew T. Dudley   +3 more
core   +1 more source

LINCing Nuclear Mechanobiology With Skeletal Muscle Mass and Function

Frontiers in Cell and Developmental Biology, 2021
Skeletal muscle demonstrates a high degree of adaptability in response to changes in mechanical input. The phenotypic transformation in response to mechanical cues includes changes in muscle mass and force generating capabilities, yet the molecular ...
Maria J. A. van Ingen, Tyler J. Kirby
doaj   +1 more source

Revealing hidden information in osteoblast’s mechanotransduction through analysis of time patterns of critical events

BMC Bioinformatics, 2020
Background Mechanotransduction in bone cells plays a pivotal role in osteoblast differentiation and bone remodelling. Mechanotransduction provides the link between modulation of the extracellular matrix by mechanical load and intracellular activity.
Gianluca Ascolani, Timothy M. Skerry, Damien Lacroix, Enrico Dall’Ara, Aban Shuaib   +4 more
doaj   +1 more source

FAK-mediated mechanotransduction in skeletal regeneration [PDF]

, 2007
The majority of cells are equipped to detect and decipher physical stimuli, and then react to these stimuli in a cell type-specific manner. Ultimately, these cellular behaviors are synchronized to produce a tissue response, but how this is achieved ...
Kim Jae-Beom, Jill A Helms, Jennifer A Currey, Leucht Philipp, Helms, Jill A., Kim, Jae-Beom, Jae-Beom Kim, Leucht, Philipp, Currey Jennifer A., Brunski John, Helms Jill A., Currey, Jennifer A., Philipp Leucht, Brunski, John, John Brunski   +14 more
core   +2 more sources

Mechanotransduction in fibroblasts [PDF]

, 2011
Response to mechanical stress is important for tissue homeostasis, tissue architecture and muscle regeneration. All cells of an organism are subject to at least one of three types of mechanical stress: compression, shear stress or tension.
Brosig, Michaela
core   +1 more source

Non-overlapping functions for Pyk2 and FAK in osteoblasts during fluid shear stress-induced mechanotransduction. [PDF]

PLoS ONE, 2011
Mechanotransduction, the process by which cells convert external mechanical stimuli such as fluid shear stress (FSS) into biochemical changes, plays a critical role in maintenance of the skeleton.
Suzanne R L Young, Julia M Hum, Eric Rodenberg, Charles H Turner, Fredrick M Pavalko   +4 more
doaj   +1 more source

Mechanotransduction as a major driver of cell behaviour: mechanisms, and relevance to cell organization and future research

Open Biology, 2021
How do cells process environmental cues to make decisions? This simple question is still generating much experimental and theoretical work, at the border of physics, chemistry and biology, with strong implications in medicine.
Pierre-Henri Puech, Pierre Bongrand
doaj   +1 more source

Metavinculin modulates force transduction in cell adhesion sites

Nature Communications, 2020
Muscle cells express an adhesion molecule called metavinculin, which has been associated with cardiomyopathies. Here, the authors employed molecular tension sensors to reveal that metavinculin expression modulates cell adhesion mechanics and they develop
Verena Kanoldt, Carleen Kluger, Christiane Barz, Anna-Lena Schweizer, Deepak Ramanujam, Lukas Windgasse, Stefan Engelhardt, Anna Chrostek-Grashoff, Carsten Grashoff   +8 more
doaj   +1 more source

Mechanotransduction: Use the Force(s) [PDF]

, 2015
Mechanotransduction - how cells sense physical forces and translate them into biochemical and biological responses - is a vibrant and rapidly-progressing field, and is important for a broad range of biological phenomena.
Rehfeldt, Florian, Kudryasheva, Galina, Paluch, Ewa K., Biais, Nicolas, Moeller, Jens, Pruitt, Beth L., Wollnik, Carina, Nelson, Celeste M., Fabry, Ben, Federle, Walter   +9 more
core   +6 more sources

Mechanical loading of desmosomes depends on the magnitude and orientation of external stress

Nature Communications, 2018
Desmosomes are intercellular adhesion complexes that connect the intermediate filament cytoskeletons of neighboring cells but direct evidence for their load-bearing nature is lacking.
Andrew J. Price, Anna-Lena Cost, Hanna Ungewiß, Jens Waschke, Alexander R. Dunn, Carsten Grashoff   +5 more
doaj   +1 more source