Results 11 to 20 of about 30,024 (214)
Mechanotransduction pathways in articular chondrocytes and the emerging role of estrogen receptor-α
Bone Research, 2023 In the synovial joint, mechanical force creates an important signal that influences chondrocyte behavior. The conversion of mechanical signals into biochemical cues relies on different elements in mechanotransduction pathways and culminates in changes in
Ning Wang +8 more
doaj +1 more source
Mechanotransduction in Skin Inflammation
Cells, 2022 In the process of mechanotransduction, the cells in the body perceive and interpret mechanical stimuli to maintain tissue homeostasis and respond to the environmental changes.
Maria S. Shutova, Wolf-Henning Boehncke
doaj +1 more source
Mechanotransduction Activity Facilitates Hair Cell Toxicity Caused by the Heavy Metal Cadmium
Frontiers in Cellular Neuroscience, 2020 Hair cells are sensitive to many insults including environmental toxins such as heavy metals. We show here that cadmium can consistently kill hair cells of the zebrafish lateral line.
Caleigh Schmid +4 more
doaj +1 more source
LINCing Nuclear Mechanobiology With Skeletal Muscle Mass and Function
Frontiers in Cell and Developmental Biology, 2021 Skeletal muscle demonstrates a high degree of adaptability in response to changes in mechanical input. The phenotypic transformation in response to mechanical cues includes changes in muscle mass and force generating capabilities, yet the molecular ...
Maria J. A. van Ingen, Tyler J. Kirby
doaj +1 more source
BMC Bioinformatics, 2020 Background Mechanotransduction in bone cells plays a pivotal role in osteoblast differentiation and bone remodelling. Mechanotransduction provides the link between modulation of the extracellular matrix by mechanical load and intracellular activity.
Gianluca Ascolani +4 more
doaj +1 more source
Non-overlapping functions for Pyk2 and FAK in osteoblasts during fluid shear stress-induced mechanotransduction. [PDF]
PLoS ONE, 2011 Mechanotransduction, the process by which cells convert external mechanical stimuli such as fluid shear stress (FSS) into biochemical changes, plays a critical role in maintenance of the skeleton.
Suzanne R L Young +4 more
doaj +1 more source
Open Biology, 2021 How do cells process environmental cues to make decisions? This simple question is still generating much experimental and theoretical work, at the border of physics, chemistry and biology, with strong implications in medicine.
Pierre-Henri Puech, Pierre Bongrand
doaj +1 more source
Mechanical loading of desmosomes depends on the magnitude and orientation of external stress
Nature Communications, 2018 Desmosomes are intercellular adhesion complexes that connect the intermediate filament cytoskeletons of neighboring cells but direct evidence for their load-bearing nature is lacking.
Andrew J. Price +5 more
doaj +1 more source
Metavinculin modulates force transduction in cell adhesion sites
Nature Communications, 2020 Muscle cells express an adhesion molecule called metavinculin, which has been associated with cardiomyopathies. Here, the authors employed molecular tension sensors to reveal that metavinculin expression modulates cell adhesion mechanics and they develop
Verena Kanoldt +8 more
doaj +1 more source
Ionizing radiation-induced long noncoding RNA CRYBG3 regulates YAP/TAZ through mechanotransduction
Cell Death and Disease, 2022 Mechanotransduction sensing of tissue architecture and cellular microenvironment is a fundamental regulator of cell fate, including cancer. Meanwhile, long noncoding RNAs (lncRNAs) play multifunctions during cancer development and treatment. However, the
Lijun Zheng +15 more
doaj +1 more source