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Tumor microenvironment and mechanotransduction pathways: Novel targets and new directions for cancer therapy [PDF]
Mechanobiology in MedicineIn cancer research, the extracellular matrix (ECM) of the tumor microenvironment (TME) was once regarded as a mere passive structural scaffold for tumor tissue, while the biomechanical cues generated by its dynamic physical remodeling have now emerged as
Xinjie Zhang +3 more
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Mechanotransduction in Development
, 2011 Biochemical patterning and morphogenetic movements coordinate the design of embryonic development. The molecular processes that pattern and closely control morphogenetic movements are today becoming well understood. Recent experimental evidence demonstrates that mechanical cues generated by morphogenesis activate mechanotransduction pathways, which in ...
Emmanuel Farge, Farge, Emmanuel
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Lamins’ role in osteosarcoma [PDF]
Frontiers in Cell and Developmental BiologyOsteosarcoma (OS) is a rare and highly aggressive bone tumor that can develop in several skeletal segments, although it predominantly affects the long bones. This cancer mostly occurs in adolescents, young adults and people older than 60.
Giulia Bagnato +3 more
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Frontiers in Molecular Neuroscience, 2022 Cisplatin is one of the most widely used chemotherapeutic drugs across the world. However, the serious ototoxic effects, leading to permanent hair cell death and hearing loss, significantly limit the utility of cisplatin.
Jinan Li +4 more
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Journal of Orthopaedic Translation, 2021 Background: Osteocytes, composing over 90% of bone cells, are well known for their mechanosensing abilities. Aged osteocytes with impaired morphology and function are less efficient in mechanotransduction which will disrupt bone turnover leading to ...
Meng Chen Michelle Li +4 more
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Response to mechanical stress is mediated by the TRPA channel painless in the Drosophila heart. [PDF]
PLoS Genetics, 2010 Mechanotransduction modulates cellular functions as diverse as migration, proliferation, differentiation, and apoptosis. It is crucial for organ development and homeostasis and leads to pathologies when defective.
Sébastien Sénatore +4 more
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A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes
Biophysical Reports, 2021 Mechanotransduction at focal adhesion complexes is key for various cellular events. Theoretical analyses were performed to predict a potential role of lipid membranes in modulating mechanotransduction at focal adhesions.
Jichul Kim
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Mechanotransduction in cancer [PDF]
Current Opinion in Chemical Engineering, 2016 Tissue stiffness is tightly controlled under normal conditions, but changes with disease. In cancer, tumors often tend to be stiffer than the surrounding uninvolved tissue, yet the cells themselves soften. Within the past decade, and particularly in the last few years, there is increasing evidence that the stiffness of the extracellular matrix ...
LiKang Chin +3 more
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Brain and Behavior, 2023 Background The brain is a highly mechanosensitive organ, and changes in the mechanical properties of brain tissue influence many physiological and pathological processes.
Qingcui Zheng +6 more
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Mechanotransduction pathways in articular chondrocytes and the emerging role of estrogen receptor-α
Bone Research, 2023 In the synovial joint, mechanical force creates an important signal that influences chondrocyte behavior. The conversion of mechanical signals into biochemical cues relies on different elements in mechanotransduction pathways and culminates in changes in
Ning Wang +8 more
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