Results 31 to 40 of about 40,337 (298)
Cell Reports, 2022 The mechanically activated Piezo channel plays a versatile role in conferring mechanosensitivity to various cell types. However, how it incorporates its intrinsic mechanosensitivity and cellular components to effectively sense long-range mechanical ...
Jing Wang +5 more
semanticscholar +1 more source
Matrix stiffness regulates osteoclast fate through integrin-dependent mechanotransduction.
Bioactive Materials, 2023 Osteoclasts ubiquitously participate in bone homeostasis, and their aberration leads to bone diseases, such as osteoporosis. Current clinical strategies by biochemical signaling molecules often perturb innate bone metabolism owing to the uncontrolled ...
Xiaogang Wang +3 more
semanticscholar +1 more source
Mechanotransduction Activity Facilitates Hair Cell Toxicity Caused by the Heavy Metal Cadmium
Frontiers in Cellular Neuroscience, 2020 Hair cells are sensitive to many insults including environmental toxins such as heavy metals. We show here that cadmium can consistently kill hair cells of the zebrafish lateral line.
Caleigh Schmid +4 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Osteoarthritis is a global health problem that affects load-bearing joints, causing loss of mobility and enormous healthcare costs. However, disease-modifying approaches are lacking.
Whasil Lee +9 more
semanticscholar +1 more source
Neuron, 2022 Adult brain activities are generally believed to be dominated by chemical and electrical transduction mechanisms. However, the importance of mechanotransduction mediated by mechano-gated ion channels in brain functions is less appreciated.
Shaopeng Chi +8 more
semanticscholar +1 more source
LINCing Nuclear Mechanobiology With Skeletal Muscle Mass and Function
Frontiers in Cell and Developmental Biology, 2021 Skeletal muscle demonstrates a high degree of adaptability in response to changes in mechanical input. The phenotypic transformation in response to mechanical cues includes changes in muscle mass and force generating capabilities, yet the molecular ...
Maria J. A. van Ingen, Tyler J. Kirby
doaj +1 more source
Biophysics of Mechanotransduction [PDF]
European Biophysics Journal, 2015 (Singer and Nicolson 1972). As a physical barrier it presents a major target of mechanical forces stretching, compressing, bending or even breaking it, if an excessive force is acting on it. As a composite of a large variety of lipid molecules such as phospholipids, sphingolipids, cholesterol and many others, the lipid bilayer of the cell membrane ...
Boris, Martinac, Andrew R, Battle
openaire +2 more sources
BMC Bioinformatics, 2020 Background Mechanotransduction in bone cells plays a pivotal role in osteoblast differentiation and bone remodelling. Mechanotransduction provides the link between modulation of the extracellular matrix by mechanical load and intracellular activity.
Gianluca Ascolani +4 more
doaj +1 more source
Mechanotransduction in cancer [PDF]
Current Opinion in Chemical Engineering, 2016 Tissue stiffness is tightly controlled under normal conditions, but changes with disease. In cancer, tumors often tend to be stiffer than the surrounding uninvolved tissue, yet the cells themselves soften. Within the past decade, and particularly in the last few years, there is increasing evidence that the stiffness of the extracellular matrix ...
LiKang Chin +3 more
openaire +2 more sources
KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation
Science immunology, 2023 Immune cells sense the microenvironment to fine-tune their inflammatory responses. Patients with cryopyrin-associated periodic syndrome (CAPS), caused by mutations in the NLRP3 gene, develop autoinflammation triggered by nonantigenic cues such as from ...
Li Ran +7 more
semanticscholar +1 more source