Results 51 to 60 of about 40,337 (298)

Integrins in Mechanotransduction [PDF]

Journal of Biological Chemistry, 2004
Mechanical forces are crucial to the regulation of cell and tissue morphology and function. At the cellular level, forces influence cytoskeletal organization, gene expression, proliferation, and survival. Integrin-mediated adhesions are intrinsically mechanosensitive and a large body of data implicates integrins in sensing mechanical forces.
Akira, Katsumi, A Wayne, Orr, Eleni, Tzima, Martin Alexander, Schwartz   +3 more
openaire   +2 more sources

Mechanotransduction in skin wound healing and scar formation: Potential therapeutic targets for controlling hypertrophic scarring

Frontiers in Immunology, 2022
Hypertrophic scarring (HTS) is a major source of morbidity after cutaneous injury. Recent studies indicate that mechanical force significantly impacts wound healing and skin regeneration which opens up a new direction to combat scarring.
Jiayi Yin, Shiming Zhang, Chao Yang, Yan Wang, B. Shi, Q. Zheng, Ni Zeng, Hanyao Huang   +7 more
semanticscholar   +1 more source

Mechanisms of Mechanotransduction [PDF]

Developmental Cell, 2006
Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces regulate a large array of physiological processes, and dysregulation of mechanical responses contributes to major human diseases. A survey of both specialized and widely expressed mechanosensitive systems suggests that physical forces provide a general means of ...
Orr, A. Wayne, Helmke, Brian P., Blackman, Brett R., Schwartz, Martin A.   +3 more
openaire   +3 more sources

Ionizing radiation-induced long noncoding RNA CRYBG3 regulates YAP/TAZ through mechanotransduction

Cell Death and Disease, 2022
Mechanotransduction sensing of tissue architecture and cellular microenvironment is a fundamental regulator of cell fate, including cancer. Meanwhile, long noncoding RNAs (lncRNAs) play multifunctions during cancer development and treatment. However, the
Lijun Zheng, Chenyu Luo, Nan Yang, Hailong Pei, Mintao Ji, Yinyin Shu, Zhisen Zhang, Shuai Dong, Xiuxiu Wang, Xuemei Li, Wensheng Zhang, Yan Wang, Bingyan Li, Tom K. Hei, Guangming Zhou, Lei Chang   +15 more
doaj   +1 more source

Purinergic P2 Receptors: Novel Mediators of Mechanotransduction

Frontiers in Pharmacology, 2021
Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial ...
Qihang Kong, Yue Quan, Geer Tian, Junteng Zhou, Xiaojing Liu, Xiaojing Liu   +5 more
doaj   +1 more source

The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis

Frontiers in Cell and Developmental Biology, 2022
Mechanical factors play critical roles in the pathogenesis of joint disorders like osteoarthritis (OA), a prevalent progressive degenerative joint disease that causes debilitating pain.
Winni Gao, Hamza Hasan, Devon E. Anderson, Whasil Lee   +3 more
semanticscholar   +1 more source

Mechanotransduction and fibrosis [PDF]

Journal of Biomechanics, 2014
Scarring and tissue fibrosis represent a significant source of morbidity in the United States. Despite considerable research focused on elucidating the mechanisms underlying cutaneous scar formation, effective clinical therapies are still in the early stages of development.
Dominik, Duscher, Zeshaan N, Maan, Victor W, Wong, Robert C, Rennert, Michael, Januszyk, Melanie, Rodrigues, Michael, Hu, Arnetha J, Whitmore, Alexander J, Whittam, Michael T, Longaker, Geoffrey C, Gurtner   +10 more
openaire   +2 more sources

The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction

Communications Biology, 2022
Dystrophin is the central protein of the dystrophin-glycoprotein complex (DGC) in skeletal and heart muscle cells. Dystrophin connects the actin cytoskeleton to the extracellular matrix (ECM).
D. Wilson, A. Tinker, Thomas Iskratsch
semanticscholar   +1 more source

Mechanotransduction in osteogenesis

Bone & Joint Research, 2020
Bone is one of the most highly adaptive tissues in the body, possessing the capability to alter its morphology and function in response to stimuli in its surrounding environment. The ability of bone to sense and convert external mechanical stimuli into a biochemical response, which ultimately alters the phenotype and function of the cell, is described ...
Stewart, S, Darwood, A, Masouros, S, Higgins, C, Ramasamy, A   +4 more
openaire   +4 more sources

Aging, Osteocytes, and Mechanotransduction [PDF]

Current Osteoporosis Reports, 2017
The bone is able to adapt its structure to mechanical signals via the bone remodeling process governed by mechanosensitive osteocytes. With aging, an imbalance in bone remodeling results in osteoporosis. In this review, we hypothesized that changes in lacunar morphology underlie the decreased bone mechanoresponsiveness to mechanical loading with aging ...
Hemmatian, Haniyeh, Bakker, Astrid D., Klein-Nulend, Jenneke, van Lenthe, Harry   +3 more
openaire   +4 more sources