Results 61 to 70 of about 40,337 (298)
Mechanotransduction in mammalian sensory hair cells.
Molecular and cellular neurosciences, 2022 In the inner ear, the auditory and vestibular systems detect and translate sensory information regarding sound and balance. The sensory cells that transform mechanical input into an electrical signal in these systems are called hair cells.
G. A. Caprara, Anthony W. Peng
semanticscholar +1 more source
Stem Cells International, 2020 Bone marrow-derived mesenchymal stromal cells (hMSCs) are capable of differentiating into the osteogenic lineage, and for osteogenic differentiation, mechanical loading is a relevant stimulus.
Sigrid Müller-Deubert +7 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2023 Ciliated sensory cells such as photo- and olfactory receptors employ multiple types of opsins or hundreds of unique olfactory G-protein coupled receptors to respond to various wavelengths of light or odorants.
Eliot T. Smith +4 more
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Physics of mechanotransduction by Piezo ion channels
The Journal of General Physiology, 2022 Young et al. review and synthesize the mechanistic principles of forces and energies involved in Piezo ion channel mechanotransduction.
M. Young, A. Lewis, J. Grandl
semanticscholar +1 more source
Mechanotransduction and nuclear function [PDF]
Current Opinion in Cell Biology, 2016 Many signaling pathways converge on the nucleus to regulate critical nuclear events such as transcription, DNA replication and cell cycle progression. While the vast majority of research in this area has focused on signals generated in response to hormones or other soluble factors, the nucleus also responds to mechanical forces.
David M, Graham, Keith, Burridge
openaire +2 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Physics of Life ReviewsIn primary or idiopathic osteoarthritis (OA), it is unclear which factors trigger the shift of articular chondrocyte activity from pro-anabolic to pro-catabolic.
M. Segarra-Queralt +4 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen +6 more
wiley +1 more source
Cellular responses to beating hydrogels to investigate mechanotransduction
Nature Communications, 2019 Mechanotransduction of cells is of interest for a number of reasons but model in vitro systems remain a challenge. Here, the authors report on a hydrogel which changes properties upon near infrared irradiation to create cyclic forces and demonstrate the ...
Yashoda Chandorkar +10 more
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