Results 61 to 70 of about 36,721 (301)

Cell mechanotransduction machinery, and signaling defects: small tools and nano-bio interface for influential regenerative remedies [PDF]

, 2021
© 2021 The Authors. Published by Longdom Publishing. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://www.longdom.org/open-access ...
Kumar, Rajiv, Gulia, Kiran
core  

Chamber‐Specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes to Drive Engineered Heart Tissue Development and Function

Advanced Healthcare Materials, EarlyView.
Chamber‐specific decellularized extracellular matrices (ECMs) were developed, preserving native proteomic profiles of ventricular and atrial myocardium. These innate biochemical cues differentially modulate cardiomyocyte subtypes to drive engineered heart tissue development and function, highlighting the importance of incorporating regional ECM cues in
Dong Gyu Hwang, Myungji Kim, Hwanyong Choi, Jinseon Park, Minji Kim, Donghwan Kim, Bo Ram Lee, Jinah Jang   +7 more
wiley   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Piezo is essential for amiloride-sensitive stretch-activated mechanotransduction in larval Drosophila dorsal bipolar dendritic sensory neurons.

, 2015
Stretch-activated afferent neurons, such as those of mammalian muscle spindles, are essential for proprioception and motor co-ordination, but the underlying mechanisms of mechanotransduction are poorly understood.
Bewick, Guy S, Jarman, Andrew P, Shenton, Fiona C, Suslak, Thomas J, Thompson, Karen J, Watson, Sonia, Armstrong, J Douglas   +6 more
core   +1 more source

Physicochemical Reinforcement Unlocks Sterilization‐Stable Anisotropic Hydrogels for Cell‐Compatible Mock Arteries

Advanced Healthcare Materials, EarlyView.
ABSTRACT In vitro arterial models offer ethical and robust alternatives for vascular research but require cytocompatible materials that replicate physiological mechanics. Poly(vinyl alcohol) (PVA) hydrogels produced by directional freezing and salting‐out (PVA DFSO) are anisotropic yet lack stability for cell culture. Herein, methacrylated PVA (PVA‐MA)
Javiera Sanhueza Ortega, Kirthen Shanmuganathan, Laura Poole‐Warren, Susann Beier, Ulises Aregueta Robles   +4 more
wiley   +1 more source

High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain [PDF]

, 2007
Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Abrahamsen, B, Robinson, M, Rugiero, F, Colless, B, Drew, LJ, Brust, A, Heinzmann, S, Lewis, RJ, Wood, JN, Gale, JE, Cesare, P, Bowden, S   +11 more
core  

Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading

, 2009
Mechanical loading of articular cartilage stimulates the metabolism of resident chondrocytes and induces the synthesis of molecules to maintain the integrity of the cartilage.
Ramage, L., Salter, D. M., Nuki, G.
core   +1 more source

Mechanism and application of feedback loops formed by mechanotransduction and histone modifications

Genes and Diseases
Mechanical stimulation is the key physical factor in cell environment. Mechanotransduction acts as a fundamental regulator of cell behavior, regulating cell proliferation, differentiation, apoptosis, and exhibiting specific signature alterations during ...
Han Sun, Yafang Gao, Xinyu Ma, Yizhou Deng, Lintao Bi, Lisha Li   +5 more
doaj   +1 more source

Matrix remodeling and mechanotransduction in in vitro chondrogenesis: Implications towards functional stem cell‐based cartilage tissue engineering

Engineering Reports, 2020
Stem cell‐based cartilage regeneration strategies take benefits from functional tissue engineering concepts that effectively exploit cells native mechanotransduction phenomenon for the development of in vitro cartilage constructs.
Nirmal S. Remya, Prabha D. Nair
doaj   +1 more source

Standardized Effect Measures Informing Next‐Generation Strategies for Mechanical Stimulation in Cartilage Tissue Engineering

Advanced Healthcare Materials, EarlyView.
This systematic review quantitatively compares conventional mechanical stimulation strategies in cartilage tissue engineering across 85 heterogeneous in vitro studies. Applying standardized effect measures, meta‐analysis reveals that combined compression and shear loading optimally promotes cartilage matrix development.
Jiaqi K. Shen, Tony B. Huang, Catherine E. Davey, Elias Salzer, Gerjo J. V. M. Van Osch, Sandra J. Shefelbine, Marcus G. Pandy, Kathryn S. Stok   +7 more
wiley   +1 more source