Results 1 to 10 of about 18,551 (276)
BiologyThe growing obesity epidemic necessitates increased research on adipocyte and adipose tissue function and disease mechanisms that progress obesity. Historically, adipocytes were viewed simply as storage for excess energy.
Steven Pagano +2 more
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Endothelial mechanobiology [PDF]
APL Bioengineering, 2020 Lining the luminal surface of the vasculature, endothelial cells (ECs) are in direct contact with and differentially respond to hemodynamic forces depending on their anatomic location.
Ming He +4 more
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Modelling cartilage mechanobiology [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2003 The growth, maintenance and ossification of cartilage are fundamental to skeletal development and are regulated throughout life by the mechanical cues that are imposed by physical activities. Finite element computer analyses have been used to study the role of local tissue mechanics on endochondral ossification patterns, skeletal ...
Dennis R Carter
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Perspectives on in silico bone mechanobio [PDF]
European Cells & Materials, 2022 Bone mechanobiology is the study of the physical, biological and mechanical processes that continuously affect the multiscale multicellular system of the bone from the organ to the molecular scale.
D Boaretti +4 more
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Mechanobiology of cancerogenesis
Klinicka onkologie, 2021 Within the tumour microenvironment, tumour cells are exposed to different mechanical stimuli such as compression stress, cell-cell and cell-extracellular matrix traction forces, interstitial fluid pressure, and shear stress. Cells actively sense and process this information by the mechanism of mechanotransduction to make decisions about their growth ...
Martina, Raudenská +3 more
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Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives
Nature Communications, 2023 In this work, the authors identify regulators of actin filament assembly involved in chiral organisation of the actin cytoskeleton in single cells and chiral alignment of cells in groups.
Yee Han Tee +15 more
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Mechanobiology of the meniscus [PDF]
Journal of Biomechanics, 2015 The meniscus plays a critical biomechanical role in the knee, providing load support, joint stability, and congruity. Importantly, growing evidence indicates that the mechanobiologic response of meniscal cells plays a critical role in the physiologic, pathologic, and repair responses of the meniscus.
McNulty, Amy L, Guilak, Farshid
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Keratocyte mechanobiology [PDF]
Experimental Eye Research, 2020 In vivo, corneal keratocytes reside within a complex 3D extracellular matrix (ECM) consisting of highly aligned collagen lamellae, growth factors, and other extracellular matrix components, and are subjected to various mechanical stimuli during developmental morphogenesis, fluctuations in intraocular pressure, and wound healing.
W Matthew, Petroll +2 more
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Mechanobiology of Ciliogenesis [PDF]
BioScience, 2014 Cilia are force-generating and -sensing organelles that serve as mechanical interfaces between the cell and the extracellular environment. Cilia are present in tissues that adaptively respond to mechanical loading and fluid flow, and defects in ciliary function can lead to diseases affecting these tissues.
Ishikawa, Hiroaki, Marshall, Wallace F
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Cancer Cell International, 2021 Highlights The major highlights of this study are as follows: Key upregulated hub kinases and coding genes in GBM are found to be targets of SUMO2 conjugation.
Aswani P. Krishna +3 more
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