The role of ECM mechanics in cancer mechanotransduction through unraveling the molecular machinery of integrins, FAK, and YAP signaling. [PDF]
Cell Mol Biol LettMechanotransduction, the process by which cells convert mechanical stimuli into biochemical signals, is fundamental for maintaining tissue homeostasis and regulating physiological functions. The extracellular matrix (ECM) serves as a critical mediator of
Hassan N, Greve B, Götte M.
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Chromatin remodelling: a driving force in reverse mechanotransduction. [PDF]
RNA BiolChromatin serves as the dynamic carrier of genetic and epigenetic information in eukaryotic cells, playing a pivotal role in maintaining nuclear shape, mechanical stability, and cellular function.
Buisson J +4 more
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Lamins' role in osteosarcoma. [PDF]
Front Cell Dev BiolOsteosarcoma (OS) is a rare and highly aggressive bone tumor that can develop in several skeletal segments, although it predominantly affects the long bones. This cancer mostly occurs in adolescents, young adults and people older than 60.
Bagnato G, Peruzzi B.
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Mechanochemical regulation of organoid morphogenesis: Integrated signaling circuits in engineered microenvironments. [PDF]
Mater Today BioOrganoid morphogenesis is orchestrated by complex mechanical interactions between cells and their microenvironment. Recent evidence highlights the critical role of mechanical stimuli—including fluid shear stress, axial tensile and compressive forces ...
Zhang X, Zhao Y, Mao L, Wang Q, Huang P.
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A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes
Biophysical Reports, 2021 Mechanotransduction at focal adhesion complexes is key for various cellular events. Theoretical analyses were performed to predict a potential role of lipid membranes in modulating mechanotransduction at focal adhesions.
Jichul Kim
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LINCing Nuclear Mechanobiology With Skeletal Muscle Mass and Function
Frontiers in Cell and Developmental Biology, 2021 Skeletal muscle demonstrates a high degree of adaptability in response to changes in mechanical input. The phenotypic transformation in response to mechanical cues includes changes in muscle mass and force generating capabilities, yet the molecular ...
Maria J. A. van Ingen, Tyler J. Kirby
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Purinergic P2 Receptors: Novel Mediators of Mechanotransduction
Frontiers in Pharmacology, 2021 Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial ...
Qihang Kong +5 more
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Substrate stiffness controls proinflammatory responses in human gingival fibroblasts
Scientific Reports, 2023 Soft gingiva is often compromised in gingival health; however, the underlying biological mechanisms remain unknown. Extracellular matrix (ECM) stiffness is involved in the progression of various fibroblast-related inflammatory disorders via cellular ...
Watcharaphol Tiskratok +5 more
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Ionizing radiation-induced long noncoding RNA CRYBG3 regulates YAP/TAZ through mechanotransduction
Cell Death and Disease, 2022 Mechanotransduction sensing of tissue architecture and cellular microenvironment is a fundamental regulator of cell fate, including cancer. Meanwhile, long noncoding RNAs (lncRNAs) play multifunctions during cancer development and treatment. However, the
Lijun Zheng +15 more
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Cells, 2022 In this review, we shed light on recent advances regarding the characterization of biochemical pathways of cellular mechanosensing and mechanotransduction with particular attention to their role in neurodegenerative disease pathogenesis.
Ilaria Tortorella +4 more
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