Phospho-regulated tethering of focal adhesion kinase to vinculin links force transduction to focal adhesion signaling [PDF]
Cell Communication and SignalingFocal Adhesion Kinase (FAK) is a key signaling molecule in focal adhesions (FAs) orchestrating the formation, maturation and turnover of the FA complex.
Karen Diaz-Palacios +6 more
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Obesity promotes urinary tract infection by disrupting bladder focal adhesion kinase signaling [PDF]
iScienceSummary: Obesity is a significant public health concern associated with numerous health risks. Infections are a major complication of obesity, but the mechanisms driving increased infection risk remain unclear. Using a diet-induced obesity mouse model in
Laura Schwartz +10 more
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The focal adhesion kinases regulate leptin action and the weight reducing effect of HDAC6 inhibition [PDF]
Nature CommunicationsThe adipokine leptin is a central regulator of energy metabolism. We previously showed that HDAC6 inhibitors enhance central leptin sensitivity. Using integrative analyses of leptin-responsive hypothalamic gene expression signatures, we identified focal ...
Colleen K. Hadley +8 more
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Focal adhesion in the tumour metastasis: from molecular mechanisms to therapeutic targets [PDF]
Biomarker ResearchThe tumour microenvironment is the “hotbed” of tumour cells, providing abundant extracellular support for growth and metastasis. However, the tumour microenvironment is not static and is constantly remodelled by a variety of cellular components ...
Zonghao Liu +6 more
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Frictiotaxis underlies focal adhesion-independent durotaxis [PDF]
Nature CommunicationsCells move directionally along gradients of substrate stiffness — a process called durotaxis. In the situations studied so far, durotaxis relies on cell-substrate focal adhesions to sense stiffness and transmit forces that drive directed motion. However,
Adam Shellard +9 more
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Transcriptional activation of MACF1 by NR2F1 drives WNT-mediated focal adhesion and metastasis in lung adenocarcinoma [PDF]
European Journal of Medical ResearchObjective To investigate the regulatory role of MACF1 and its upstream transcriptional control in focal adhesion remodeling and tumor progression in lung adenocarcinoma (LUAD).
Yi Zhou +4 more
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Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation [PDF]
eLifeLiquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form LLPS, which govern adhesion dynamics and related cell
Abhishek Kumar +2 more
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PIPKIγ regulates focal adhesion dynamics and colon cancer cell invasion. [PDF]
PLoS ONE, 2011 Focal adhesion assembly and disassembly are essential for cell migration and cancer invasion, but the detailed molecular mechanisms regulating these processes remain to be elucidated. Phosphatidylinositol phosphate kinase type Iγ (PIPKIγ) binds talin and
Zhaofei Wu +5 more
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Cell Adhesion & Migration, 2021 MAGI1 is an intracellular adaptor protein that stabilizes cell junctions and regulates epithelial and endothelial integrity. Here, we report that that in endothelial cells MAGI1 colocalizes with paxillin, β3-integrin, talin 1, tensin 3 and α-4-actinin at
Begoña Alday-Parejo +7 more
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Frontiers in Cell and Developmental Biology, 2021 Background: Focal adhesion, as the intermediary between tumor cells and extracellular matrix communication, plays a variety of roles in tumor invasion, migration, and drug resistance.
Deli Mao +18 more
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