Results 41 to 50 of about 823,784 (150)

Wound-induced polyploidization is dependent on Integrin-Yki signaling

Biology Open, 2021
A key step in tissue repair is to replace lost or damaged cells. This occurs via two strategies: restoring cell number through proliferation or increasing cell size through polyploidization.
Rose Besen-McNally, Kayla J. Gjelsvik, Vicki P. Losick   +2 more
doaj   +1 more source

Overexpressed Focal Adhesion Kinase Predicts a Higher Incidence of Extrahepatic Metastasis and Worse Survival in Hepatocellular Carcinoma

, 2011
Focal adhesion kinase plays a critical role in cancer progression, invasion, and metastasis. Although focal adhesion kinase overexpression indicates poor prognoses for hepatocellular carcinoma, its role in hepatocellular carcinoma metastasis has not been
詹以吉;柯博升;許駿;王約翰;劉俊揚, JAN, YEE-JEE;KO, BO-SHENG;HSU, CHIUN;WANG, JOHN;LIOU, JUN-YANG   +1 more
core   +1 more source

Focal adhesions are controlled by microtubules through local contractility regulation

The EMBO Journal
Microtubules regulate cell polarity and migration via local activation of focal adhesion turnover, but the mechanism of this process is insufficiently understood.
Julien Aureille, Srinivas S Prabhu, Sam F Barnett, Aaron J Farrugia, Isabelle Arnal, Laurence Lafanechère, Boon Chuan Low, Pakorn Kanchanawong, Alex Mogilner, Alexander D Bershadsky   +9 more
doaj   +1 more source

An evolutionary and physiological perspective on cell-substrate adhesion machinery for cell migration

Frontiers in Cell and Developmental Biology, 2022
Cell-substrate adhesion is a critical aspect of many forms of cell migration. Cell adhesion to an extracellular matrix (ECM) generates traction forces necessary for efficient migration.
Julio C. Fierro Morales, Qian Xue, Minna Roh-Johnson   +2 more
doaj   +1 more source

Focal adhesion in the tumour metastasis: from molecular mechanisms to therapeutic targets

Biomarker Research
The tumour microenvironment is the “hotbed” of tumour cells, providing abundant extracellular support for growth and metastasis. However, the tumour microenvironment is not static and is constantly remodelled by a variety of cellular components ...
Zonghao Liu, Xiaofang Zhang, Tianru Ben, Mo Li, Yi Jin, Tianlu Wang, Yingqiu Song   +6 more
doaj   +1 more source

Chemoresistant ovarian cancer enhances its migration abilities by increasing store-operated Ca2+ entry-mediated turnover of focal adhesions

Journal of Biomedical Science, 2020
Background Among gynecological cancers, ovarian carcinoma has the highest mortality rate, and chemoresistance is highly prevalent in this cancer. Therefore, novel strategies are required to improve its poor prognosis.
Ho-Kai Huang, Yi-Hsin Lin, Heng-Ai Chang, Yi-Shyun Lai, Ying-Chi Chen, Soon-Cen Huang, Cheng-Yang Chou, Wen-Tai Chiu   +7 more
doaj   +1 more source

Abnormal Endothelial Gene Expression Associated With Early Coronary Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background We examined feasibility of a unique approach towards gaining insight into heritable risk for early atherosclerosis: surveying gene expression by endothelial cells from living subjects. Methods and Results Subjects aged
Robert P. Hebbel, Peng Wei, Liming Milbauer, Michel T. Corban, Anna Solovey, James Kiley, Jack Pattee, Lilach O. Lerman, Wei Pan, Amir Lerman   +9 more
doaj   +1 more source

Focal adhesion intensity measurement

, 2022
Attached is  Focal adhesion intensity measurement. 
Ting Yu Yeh (10691049)
core   +1 more source

HAb18G/CD147 regulates vinculin-mediated focal adhesion and cytoskeleton organization in cultured human hepatocellular carcinoma cells. [PDF]

PLoS ONE, 2014
Focal adhesions (FAs), integrin-mediated macromolecular complexes located at the cell membrane extracellular interface, have been shown to regulate cell adhesion and migration.
Qiang Liang, Qing Han, Wan Huang, Gang Nan, Bao-Qing Xu, Jian-Li Jiang, Zhi-Nan Chen   +6 more
doaj   +1 more source

A celiac cellular phenotype, with altered LPP sub-cellular distribution, is inducible in controls by the toxic gliadin peptide P31-43. [PDF]

PLoS ONE, 2013
Celiac disease (CD) is a frequent inflammatory intestinal disease, with a genetic background, caused by gliadin-containing food. Undigested gliadin peptides P31-43 and P57-68 induce innate and adaptive T cell-mediated immune responses, respectively ...
Merlin Nanayakkara, Roberta Kosova, Giuliana Lania, Marco Sarno, Alessandra Gaito, Martina Galatola, Luigi Greco, Marialaura Cuomo, Riccardo Troncone, Salvatore Auricchio, Renata Auricchio, Maria Vittoria Barone   +11 more
doaj   +1 more source