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A Layered View on Focal Adhesions. [PDF]

Biology (Basel), 2021
The cytoskeleton provides structure to cells and supports intracellular transport. Actin fibres are crucial to both functions. Focal Adhesions (FAs) are large macromolecular multiprotein assemblies at the ends of specialised actin fibres linking these to the extracellular matrix.
Legerstee K, Houtsmuller AB.
europepmc   +6 more sources

Redox regulation of focal adhesions. [PDF]

Redox Biol
Focal adhesions (FAs), multi-protein complexes that link the extracellular matrix to the intracellular cytoskeleton, are key mediators of cell adhesion, migration, and proliferation. These dynamic structures act as mechanical sensors, transmitting stimuli from the extracellular to intracellular environment activating in this way signaling pathways and ...
Matrullo G, Filomeni G, Rizza S.
europepmc   +5 more sources

Focal adhesions in osteoneogenesis [PDF]

Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 2010
As materials technology and the field of tissue engineering advance, the role of cellular adhesive mechanisms, in particular, interactions with implantable devices, becomes more relevant in both research and clinical practice. A key tenet of medical device technology is to use the exquisite ability of biological systems to respond to the material ...
M J P, Biggs, M J, Dalby
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TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly [PDF]

Journal of Cell Science, 2014
Focal adhesions (FAs) are macromolecular complexes that connect the actin cytoskeleton to the extracellular matrix. Dynamic turnover of FAs is critical for cell migration. Paxillin is a multi-adaptor protein that plays an important role in regulating FA dynamics.
Pradeep D, Uchil, Tobias, Pawliczek, Tracy D, Reynolds, Siyuan, Ding, Angelika, Hinz, James B, Munro, Fang, Huang, Robert W, Floyd, Haitao, Yang, William L, Hamilton, Joerg, Bewersdorf, Yong, Xiong, David A, Calderwood, Walther, Mothes   +13 more
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Focal Adhesions [PDF]

Circulation Research, 2006
The vascular wall contains intimal endothelium and medial smooth muscle that act as contiguous tissues with tight spatial and functional coordination in response to tonic and episodic input from the bloodstream and the surrounding parenchyma. Focal adhesions are molecular bridges between the intracellular and extracellular spaces that integrate a ...
Lewis H, Romer, Konstantin G, Birukov, Joe G N, Garcia   +2 more
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Calcium Rises Locally Trigger Focal Adhesion Disassembly and Enhance Residency of Focal Adhesion Kinase at Focal Adhesions [PDF]

Journal of Biological Chemistry, 2004
Focal adhesion kinase (FAK) activity and Ca(2+) signaling led to a turnover of focal adhesions (FAs) required for cell spreading and migration. We used yellow Cameleon-2 (Ycam), a fluorescent protein-based Ca(2+) sensor fused to FAK or to a FAK-related non-kinase domain, to measure simultaneously local Ca(2+) variations at FA sites and FA dynamics ...
Grégory, Giannone, Philippe, Rondé, Mireille, Gaire, Joël, Beaudouin, Jacques, Haiech, Jan, Ellenberg, Kenneth, Takeda   +6 more
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Focal Adhesion Kinase: a regulator of focal adhesion dynamics and cell movement [PDF]

Oncogene, 2000
Engagement of integrin receptors with extracellular ligands gives rise to the formation of complex multiprotein structures that link the ECM to the cytoplasmic actin cytoskeleton. These adhesive complexes are dynamic, often heterogeneous structures, varying in size and organization.
J T, Parsons, K H, Martin, J K, Slack, J M, Taylor, S A, Weed   +4 more
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Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration [PDF]

Scientific Reports, 2015
AbstractDirected cell migration requires dynamical control of the protein complex within focal adhesions (FAs) and this control is regulated by signaling events involving tyrosine phosphorylation. We screened the SH2 domains present in tyrosine-specific kinases and phosphatases found within FAs, including SRC, SHP1 and SHP2 and examined whether these ...
Jui-Chung Wu, Yu-Chen Chen, Chih-Ting Kuo, Helen Wenshin Yu, Yin-Quan Chen, Arthur Chiou, Jean-Cheng Kuo   +6 more
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FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

Annual Review of Cell and Developmental Biology, 1996
▪ Abstract  Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture. They provide a structural link between the actin cytoskeleton and the extracellular matrix and are regions of signal transduction that relate to growth control.
K, Burridge, M, Chrzanowska-Wodnicka
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Focal Adhesion Kinases in Adhesion Structures and Disease [PDF]

Journal of Signal Transduction, 2012
Cell adhesion to the extracellular matrix (ECM) is essential for cell migration, proliferation, and embryonic development. Cells can contact the ECM through a wide range of matrix contact structures such as focal adhesions, podosomes, and invadopodia.
Eleniste, Pierre P, Bruzzaniti, Angela
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