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A Layered View on Focal Adhesions [PDF]
Biology, 2021 The cytoskeleton provides structure to cells and supports intracellular transport. Actin fibres are crucial to both functions. Focal Adhesions (FAs) are large macromolecular multiprotein assemblies at the ends of specialised actin fibres linking these to
Karin Legerstee, Adriaan B. Houtsmuller
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Focal adhesions, contractility, and signaling. [PDF]
Annual Review of Cell and Developmental Biology, 1996 ▪ Abstract Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture. They provide a structural link between the actin cytoskeleton and the extracellular matrix and are regions of signal transduction that relate to growth control.
K. Burridge, M. Chrzanowska-Wodnicka
semanticscholar +8 more sources
Redox regulation of focal adhesions [PDF]
Redox BiologyFocal adhesions (FAs), multi-protein complexes that link the extracellular matrix to the intracellular cytoskeleton, are key mediators of cell adhesion, migration, and proliferation.
Gianmarco Matrullo +2 more
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Step-by-step quantitative analysis of focal adhesions
MethodsX, 2014 Focal adhesions (FAs) are specialized adhesive structures which serve as cellular communication units between cells and the surrounding extracellular matrix. FAs are involved in signal transduction and actin cytoskeleton organization.
Utku Horzum +2 more
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Focal adhesions contain three specialized actin nanoscale layers. [PDF]
Nat CommunFocal adhesions (FAs) connect inner workings of cell to the extracellular matrix to control cell adhesion, migration and mechanosensing. Previous studies demonstrated that FAs contain three vertical layers, which connect extracellular matrix to the ...
Kumari R +14 more
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Hemidesmosomes modulate force generation via focal adhesions
Journal of Cell Biology, 2020 This study reveals a novel role of hemidesmosomes in resisting actomyosin-generated cellular tension, which is dependent on mechanical coupling of focal adhesions to hemidesmosomes and inhibition of mechanosensitive signaling.
Arnoud Sonnenberg, , Stefano Coppola
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Journal of Cell Biology, 2019 Puleo et al. identify the Ena/VASP protein EVL as a crucial actin polymerization factor at focal adhesions, which regulates focal adhesion maturation and mechanosensing.
Denise J Roe +2 more
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Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration [PDF]
Scientific Reports, 2015 Directed cell migration requires dynamical control of the protein complex within focal adhesions (FAs) and this control is regulated by signaling events involving tyrosine phosphorylation.
Jui-Chung Wu +6 more
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Focal adhesions: a personal perspective on a half century of progress
FEBS Journal, 2017 Focal adhesions (FAs) are specialized sites within the cell where clustered integrin receptors interact with the extracellular matrix on the outside of cells and with the actin cytoskeleton on the inside.
Keith Burridge
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eLife, 2016 The cross-talk between dynamic microtubules and integrin-based adhesions to the extracellular matrix plays a crucial role in cell polarity and migration.
Benjamin P Bouchet +9 more
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