Results 31 to 40 of about 74,823 (197)
The mechano-chemistry of cytoskeletal force generation [PDF]
, 2014 In this communication, we propose a model to study the non-equilibrium process by which actin stress fibers develop force in contractile cells. The emphasis here is on the non-equilibrium thermodynamics, which is necessary to address the mechanics as ...
Garikipati, Krishna, Maraldi, Mirko
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Dynamin as a Mover and Pincher during Cell Migration and Invasion [PDF]
, 2006 The large GTPase dynamin, long known for its role in endocytosis, has most recently been implicated as a facilitator of cell migration and invasion. Recent observations link dynamin to the cycle of membrane expansion and retraction essential for cell ...
Kruchten, Anne E., McNiven, Mark A.
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Functions of nonmuscle myosin II in assembly of the cellular contractile system. [PDF]
PLoS ONE, 2012 The contractile system of nonmuscle cells consists of interconnected actomyosin networks and bundles anchored to focal adhesions. The initiation of the contractile system assembly is poorly understood structurally and mechanistically, whereas system's ...
Maria Shutova +3 more
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Mechanical and Systems Biology of Cancer [PDF]
, 2018 Mechanics and biochemical signaling are both often deregulated in cancer, leading to cancer cell phenotypes that exhibit increased invasiveness, proliferation, and survival.
Bakal, Chris +2 more
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BMC Cell Biology, 2011 Background Cell migration plays an important role in many physiological and pathological processes, including immune cell chemotaxis and cancer metastasis.
Wang Wenqi, Liu Yang, Liao Kan
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In vivo epidermal migration requires focal adhesion targeting of ACF7
Nature Communications, 2016 The spectraplakin protein ACF7 binds to actin at focal adhesions and targets microtubule plus ends to focal adhesions, promoting their disassembly. Here the authors reveal that ACF7 is phosphorylated by Src/FAK, and this regulates actin binding and focal
Jiping Yue +11 more
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Vinculin expression in MC3T3-E1 cells in response to mechanical stimulus
Data in Brief, 2016 Loading frequency is known to influence the expression of the focal adhesions of the adherent cells. A small cyclical tensile force was transmitted to mouse pre-osteoblast MC3T3-E1 cells through PDMS substrates of varying stiffness.
J.J. Cora-Cruz +2 more
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Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. [PDF]
, 2014 Ewing sarcoma is the second-most-common bone cancer in children. Driven by an oncogenic chromosomal translocation that results in the expression of an aberrant transcription factor, EWS/FLI, the disease is typically aggressive and micrometastatic upon ...
Beckerle, Mary C +8 more
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FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING
Annual Review of Cell and Developmental Biology, 1996 ▪ Abstract  Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture. They provide a structural link between the actin cytoskeleton and the extracellular matrix and are regions of signal transduction that relate to growth control.
K, Burridge, M, Chrzanowska-Wodnicka
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Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration [PDF]
Scientific Reports, 2015 AbstractDirected cell migration requires dynamical control of the protein complex within focal adhesions (FAs) and this control is regulated by signaling events involving tyrosine phosphorylation. We screened the SH2 domains present in tyrosine-specific kinases and phosphatases found within FAs, including SRC, SHP1 and SHP2 and examined whether these ...
Jui-Chung Wu +6 more
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