Results 1 to 10 of about 4,512 (151)

The interaction of p130Cas with PKN 3 promotes malignant growth

Molecular Oncology, 2019
Protein p130Cas constitutes an adaptor protein mainly involved in integrin signaling downstream of Src kinase. Owing to its modular structure, p130Cas acts as a general regulator of cancer cell growth and invasiveness induced by different oncogenes ...
Daniel Rosel, Jan Brábek, Jakub Gemperle   +2 more
exaly   +3 more sources

p130Cas is required for androgen-dependent postnatal development regulation of submandibular glands [PDF]

Scientific Reports, 2023
Salivary glands develop through epithelial-mesenchymal interactions and are formed through repeated branching. The Crk-associated substrate protein (p130Cas) serves as an adapter that forms a complex with various proteins via integrin and growth factor ...
Jing Gao, Aonan Li, Shinsuke Fujii, Fei Huang, Chihiro Nakatomi, Ichiro Nakamura, Hiroaki Honda, Tamotsu Kiyoshima, Eijiro Jimi   +8 more
doaj   +4 more sources

Immunohistochemical Study of the BCAR1/p130Cas Protein in Non-Malignant and Malignant Human Breast Tissue [PDF]

International Journal of Biological Markers, 2001
BCAR1/p130Cas is a docking protein involved in intracellular signaling pathways and in vitro resistance of estrogen-dependent breast cancer cells to antiestrogens.
J A Foekens, T H van der Kwast
exaly   +3 more sources

Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation [PDF]

eLife
Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form LLPS, which govern adhesion dynamics and related cell
Abhishek Kumar, Keiichiro Tanaka, Martin A Schwartz   +2 more
doaj   +2 more sources

P130cas-FAK interaction is essential for YAP-mediated radioresistance of non-small cell lung cancer [PDF]

Cell Death and Disease, 2022
Based on the RNA-sequencing data, previous studies revealed that extracellular matrix receptor interaction and focal adhesion signaling pathways were enriched in radioresistant non-small cell lung cancer (NSCLC) cell lines.
Jingduo Li, Xiupeng Zhang, Zaiyu Hou, Siqi Cai, Yingxue Guo, Limei Sun, Ailin Li, Qingchang Li, Enhua Wang, Yuan Miao   +9 more
doaj   +2 more sources

Dynamic Remodeling of Mechano-Sensing Complexes in Suspended Fibroblast Cell-Sheets Under External Mechanical Stimulus. [PDF]

Biotechnol Bioeng
A cell‐sheet prepared from NIH 3T3 cells was sustained by a pair of glass microneedles above a glass‐bottom dish under the spinning disc confocal microscope equipped with a dual‐view system (left). The cell‐sheet was mechanically stretched by moving one of the microneedles away from the other and the locations of proteins related to focal adhesion were
Suzuki M, Kawauchi K, Machiyama H, Hirata H, Ishiwata S, Fujita H.   +5 more
europepmc   +2 more sources

The role of p130Cas/BCAR1 adaptor protein in the pathogenesis of cardiovascular diseases: A literature review [PDF]

American Heart Journal Plus
Breast cancer anti-estrogen resistance-1 (p130Cas/BCAR1) is an adaptor protein of the cas(Cas) family. This protein regulates multiple complex pathways in different organs including bones, pancreas, and immune and cardiovascular systems.
Ghazal Ghasempour Dabaghi, Mehrdad Rabiee Rad, Reza Amani-Beni, Bahar Darouei   +3 more
doaj   +2 more sources

ABL kinases regulate FGF signaling independent of CRK phosphorylation to prevent Peters anomaly type II [PDF]

Nature Communications
Peters anomaly is an anterior segment dysgenesis and a leading cause of congenital corneal opacity. Here, we show that loss of ABL kinases restores lens induction in the absence of FGF signaling but induces Peters anomaly type II independently of ERK ...
Hao Wu, Yingyu Mao, Qian Wang, Honglian Yu, Michael Bouaziz, Neoklis Makrides, Enpeng Wang, Zhipeng Ding, Anthony J. Koleske, Glenn L. Radice, Jerry Hsu, Xin Zhang   +11 more
doaj   +2 more sources

CSRP2 promotes the glioblastoma mesenchymal phenotype via p130Cas-mediated NF-κB and MAPK pathways [PDF]

Journal of Experimental & Clinical Cancer Research
Background Cysteine-rich protein 2 (CSRP2) plays a role in a variety of biological processes including cell proliferation and differentiation. However, whether and how CSRP2 participates in the malignancy of glioblastoma multiforme (GBM), including its ...
Jiawei He, Liang Zhang, Hao Xu, Chengtian Gao, Wentao Zhao, Bingchang Zhang, Wanhong Han, Wenpeng Zhao, Guowei Tan, Sifang Chen, Ping Zhong, Zhe Shen, Jian Meng, Ziqian Tang, Hanwen Lu, Xin Gao, Zhangyu Li, Wenhua Li, Jianyao Mao, Bosen Liu, Yun-wu Zhang, Zhanxiang Wang   +21 more
doaj   +2 more sources

The Src family kinase inhibitor drug Dasatinib and glucocorticoids display synergistic activity against tongue squamous cell carcinoma and reduce MET kinase activity [PDF]

Cell Communication and Signaling
Background Tongue squamous cell carcinoma (TSCC) is an aggressive cancer associated with a poor prognosis and limited treatment options, necessitating new drug targets to improve therapeutic outcomes.
Ali N. A. Hmedat, Jessica Doondeea, Daniel Ebner, Stephan M. Feller, Marc Lewitzky   +4 more
doaj   +2 more sources