The p130Cas-Crk/CrkL Axis: A Therapeutic Target for Invasive Cancers Unveiled by Collaboration Among p130Cas, Crk, and CrkL [PDF]
International Journal of Molecular SciencesNumerous studies have documented the involvement of p130Cas (Crk-associated substrate) in a wide range of cellular processes across different types of cells.
Taeju Park, Pegah Farhadi
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Puromycin aminonucleoside modulates p130Cas of podocytes [PDF]
Korean Journal of Pediatrics, 2012 PurposePuromycin aminonucleoside (PAN) specifically injures podocytes, leading to foot process effacement, actin cytoskeleton disorganization, and abnormal distribution of slit diaphragm proteins. p130Cas is a docking protein connecting F-actin fibers to
Tae-Sun Ha +2 more
doaj +2 more sources
Expression of p130cas, E-cadherin and β-catenin and their correlation with clinicopathological parameters in non-small cell lung cancer: p130cas over-expression predicts poor prognosis [PDF]
Folia Histochemica et Cytobiologica, 2012 p130cas (p130 Crk-associated substrate) is a scaffolding protein and plays an important role in regulating focal adhesion and driving cell migration. Also, the destruction of E-cadherin/β-catenin adhesive complex is one of the changes that characterizes ...
Yuan Miao +8 more
doaj +3 more sources
Breast Cancer: Targets and Therapy, 2009 Anna C Cunningham-Edmondson1,2, Steven K Hanks11Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; 2Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA, USAAbstract:
Anna C Cunningham-Edmondson +1 more
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Targeting Tn Antigen Suppresses Aberrant O-Glycosylation-Elicited Metastasis in Breast Cancer. [PDF]
J Cell Mol MedABSTRACT The Tn antigen, a truncated O‐glycan representing aberrant mucin‐type O‐glycosylation, is frequently observed in human breast cancer. However, the functional role of Tn antigen in breast cancer metastasis remains insufficiently investigated. This study aimed to elucidate the expression profile of Tn antigen in breast cancer and its potential ...
Du T +6 more
europepmc +2 more sources
Phosphorylation of p130Cas initiates Rac activation and membrane ruffling [PDF]
BMC Cell Biology, 2008 Background Non-receptor tyrosine kinases (NTKs) regulate physiological processes such as cell migration, differentiation, proliferation, and survival by interacting with and phosphorylating a large number of substrates simultaneously.
Sharma Alok, Mayer Bruce J
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Reduced nephrin tyrosine phosphorylation impairs podocyte force transmission and accelerates detachment in disease [PDF]
iScienceSummary: Podocytes are specialized kidney cells that form the slit diaphragm (SD), an intercellular filtration barrier against plasma protein loss. The SD is subject to significant mechanical strain which can be amplified in disease, leading to podocyte ...
Casey R. Williamson +9 more
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, 1998 The cell signaling docking protein p130cas became tyrosine-phosphorylated in SH-SY5Y human neuroblastoma cells during induced differentiation with 12-O-tetradecanoylphorbol-13-acetate (TPA) and serum or a combination of basic fibroblast growth factor ...
Nånberg, Eewa, +2 more
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P130Cas attenuates epidermal growth factor (EGF) receptor internalization by modulating EGF-triggered dynamin phosphorylation. [PDF]
PLoS ONE, 2011 BACKGROUND: Endocytosis controls localization-specific signal transduction via epidermal growth factor receptor (EGFR), as well as downregulation of that receptor. Extracellular matrix (ECM)-integrin coupling induces formation of macromolecular complexes
Yong Seok Kang +5 more
doaj +1 more source
p130Cas/BCAR1 and p140Cap/SRCIN1 Adaptors: The Yin Yang in Breast Cancer?
Frontiers in Cell and Developmental Biology, 2021 p130Cas/BCAR1 is an adaptor protein devoid of any enzymatic or transcriptional activity, whose modular structure with various binding motifs, allows the formation of multi-protein signaling complexes.
Giorgia Centonze +5 more
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