Results 31 to 40 of about 4,512 (151)
PLoS ONE, 2010 The docking protein p130Cas is a prominent Src substrate found in focal adhesions (FAs) and is implicated in regulating critical aspects of cell motility including FA disassembly and protrusion of the leading edge plasma membrane.
Leslie M Meenderink +5 more
doaj +1 more source
Skeletal Muscle, 2019 Background Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat sports-related muscle injuries. However, NSAIDs were recently shown to impede the muscle healing process after acute injury.
Chih-Hao Liao +5 more
doaj +1 more source
Altering FAK-paxillin interactions reduces adhesion, migration and invasion processes. [PDF]
PLoS ONE, 2014 Focal adhesion kinase (FAK) plays an important role in signal transduction pathways initiated at sites of integrin-mediated cell adhesion to the extracellular matrix.
Thérèse B Deramaudt +6 more
doaj +1 more source
HUBUNGAN ANTARA IMUNOEKSPRESI P130CAS DENGAN KARSINOMA TIROID PAPILARIS
Saintika Medika, 2012 Introduction: There are difficulties to determine follicular variants of papillary thyroid carcinomas if the pathological examination revealed no ground glass appearance in the nuclei/Orphan Annie eye, because the diagnosis of papillary thyroid ...
Mochamad Alex Sander
doaj +1 more source
eLife, 2022 Integrin adhesion complexes (IACs) are integrin-based plasma-membrane-associated compartments where cells sense environmental cues. The physical mechanisms and molecular interactions that mediate initial IAC formation are unclear.
Lindsay B Case +3 more
doaj +1 more source
Redox Biology, 2014 Shifts in intracellular Reactive Oxygen Species (ROS) have been shown to contribute to carcinogenesis and to tumor progression. In addition to DNA and cell damage by surges in ROS, sub-lethal increases in ROS are implicated in regulating cellular ...
Nadine Hempel, J. Andres Melendez
doaj +1 more source
Structural-based Investigation of FAK and P130Cas in Focal Adhesion [PDF]
, 2015 Cell migration is an integrated multistep process accompanying us throughout life, from birth to death. It contributes to a variety of biological activities and has been implicated in many pathological conditions, including cancer, primary ...
Zhang, Chi
core +1 more source
Advances in FGF/FGFR Signaling: Implications for Disease and Therapy
MedComm, Volume 7, Issue 9, September 2026.The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song +4 more
wiley +1 more source
A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics
eLife, 2021 Integrin adhesion complexes regulate cytoskeletal dynamics during cell migration. Adhesion activates phosphorylation of integrin-associated signaling proteins, including Cas (p130Cas, BCAR1), by Src-family kinases.
Elizabeth M Steenkiste +4 more
doaj +1 more source
Coronary Microvascular Dysfunction: Epidemiology, Pathophysiology, Diagnosis, and Treatment
MedComm, Volume 7, Issue 8, August 2026.This visual summary illustrates the key aspects of coronary microvascular dysfunction (CMD) in angina with nonobstructive coronary artery disease (NOCAD), including epidemiology, pathophysiology (microvascular remodeling and endothelial dysfunction), the protective NRG‐1/ErbB signaling pathway, diagnostic methods, and both Western and traditional ...
Zhao Ge +8 more
wiley +1 more source