Results 41 to 50 of about 4,512 (151)
A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley +1 more source
The interaction of p130Cas with PKN3 promotes malignant growth
, 2018 Protein p130Cas constitutes an adaptor protein mainly involved in integrin signaling downstream of Src kinase. Owing to its modular structure, p130Cas acts as a general regulator of cancer cell growth and invasiveness induced by different oncogenes ...
Jakub Gemperle +4 more
core +1 more source
Cell Mechanics in Cancer: Integrating Mechanotransduction Pathways Within the Tumor Microenvironment
Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.ABSTRACT Single‐cell mechanical properties such as stiffness, elasticity, and viscosity, are crucial in governing biological processes like migration, proliferation, and differentiation. In cancer, the mechanical properties of cells undergo significant alterations, which contribute to tumor growth, metastasis, and resistance to therapy.
Merve Sevgi +7 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, Volume 20, Issue 4, Page 1041-1060, April 2026.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Propojení signalizace PKN3 a p130Cas/BCAR1 [PDF]
, 2016 Both p130Cas and PKN3 are important regulators of cellular signaling deregulation of which leads to malignant behavior of cancer cells. Recently we have found that SH3 domain of p130Cas mediates interaction with proline rich region of PKN3 suggesting ...
Dibus, Michal
core
Ezrin Is Associated with Disease Progression in Ovarian Carcinoma.
PLoS ONE, 2016 ObjectiveEzrin and p130Cas are structural proteins with an important role in signaling pathways and have been shown to promote cancer dissemination. We previously reported on overexpression of both ezrin and p130Cas in breast carcinoma effusions compared
Vered Horwitz +5 more
doaj +1 more source
Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren +4 more
wiley +1 more source
Dysregulation of Blimp1 transcriptional repressor unleashes p130Cas/ErbB2 breast cancer invasion
Scientific Reports, 2017 ErbB2 overexpression is detected in approximately 20% of breast cancers and is correlated with poor survival. It was previously shown that the adaptor protein p130Cas/BCAR1 is a crucial mediator of ErbB2 transformation and that its overexpression confers
Marianna Sciortino +10 more
doaj +1 more source
PLoS ONE, 2014 Oligodendrocytes are the myelinating glial cells of the central nervous system. In the course of brain development, oligodendrocyte precursor cells migrate, scan the environment and differentiate into mature oligodendrocytes with multiple cellular ...
Constantin Gonsior +7 more
doaj +1 more source
The Role of Surface Molecules in Host Responses of Leishmaniasis: Focus on Lipid Mediators [PDF]
Journal of Research in Applied and Basic Medical Sciences, 2022 Leishmaniasis is a neglected disease that affects more than 12 million people worldwide. After parasite inoculum by female blood-sucking insects, e.g. Phlebotomus, neutrophils quickly infiltrate and phagocytes Leishmania parasites.
Ali Fattahi bafghi +3 more
doaj