Results 61 to 70 of about 4,512 (151)
Analýza úlohy SH3 domény proteinu p130Cas v jeho signalizaci [PDF]
, 2018 IN CZECH Adaptorový protein p130Cas (CAS, BCAR1) propojuje signalizaci od integrinových receptorů s receptory růstových faktorů a ovlivňuje správný embryonální vývoj a tkáňovou homeostázu.
Gemperle, Jakub
core
PLoS Computational Biology, 2014 Mechanical stretch-induced tyrosine phosphorylation in the proline-rich 306-residue substrate domain (CasSD) of p130Cas (or BCAR1) has eluded an experimentally validated structural understanding.
Kinya Hotta +11 more
doaj +1 more source
Cuproplasia and cuproptosis, two sides of the coin
Cancer Communications, Volume 45, Issue 5, Page 505-524, May 2025.Abstract Copper is an essential micronutrient in the human body, mainly acting as a crucial cofactor required for a wide range of physiological processes across nearly all cell types. Recent advances revealed that tumor cells seize copper to fulfill their rapid proliferation, metastasis, immune evasion, and so on by reprogramming the copper regulatory ...
Kaizhong Lu +4 more
wiley +1 more source
Proteasome inhibition, the pursuit of new cancer therapeutics, and the adaptor molecule p130Cas
BMC Biology, 2011 Current interest in proteasome inhibitors for cancer therapy has stimulated considerable research efforts to identify the molecular pathway to their cytotoxicity with a view to identifying the mechanisms of sensitivity and resistance as well as informing
Anderson Kenneth C, Chauhan Dharminder
doaj +1 more source
Decoding the Implications of Zinc in the Development and Therapy of Leukemia
Advanced Science, Volume 12, Issue 9, March 6, 2025.Zinc's pivotal role in hematological development and its therapeutic potential in leukemia are explored. This review delves into the complex interplay of zinc signaling in leukemia progression and treatment. It highlights recent advancements, such as zinc's regulation of ferroptosis and its impact on immunotherapy, underscoring the need for zinc‐based ...
Bo Zhu +9 more
wiley +1 more source
Nature Communications, 2019 O-glycosylation of neuropilin-1 is involved in cancer migration and invasion. Here, the authors show that defects in N-glycosylation of two neuropilin-1 splice variants enhance the co-internalisation of Met, it’s interaction with β1-integrin, and ...
Xiuping Huang +10 more
doaj +1 more source
International Journal of Genomics, Volume 2025, Issue 1, 2025.The role of sphingolipid metabolism (SM) dysregulation in promoting bladder cancer (BLCA) progression and influencing patient prognosis has been well documented. To enhance therapeutic strategies, we aimed to identify key sphingolipid metabolism–related genes (SMGs) and develop a prognostic signature for personalized BLCA management. In this study, 430
Zechun Peng +4 more
wiley +1 more source
Analyzing the role of the p130Cas SH3 domain in p130Cas-mediated signaling
, 2018 The adaptor protein p130Cas (CAS, BCAR1) represents a nodal signaling platform for integrin and growth factor receptor signaling, and influences normal development and tissue homeostasis.
Gemperle, Jakub
core
The role of p130CAS in mechanosensing [PDF]
, 2012 Sensing mechanical stimuli by proteins and their conversion into biochemical signals in a mechanotransduction is the recently discussed topic in cell biology.
Braniš, Jaroslav
core
Inhibition of p130cas tyrosine phosphorylation by calyculin A
, 1998 P130cas is a dominant tyrosine phosphorylated protein in v-src-and v-crk-transformed cells. Tyrosine phosphorylation also occurs in response to integrin-mediated cell adhesion. P130cas has a unique structure with multiple SH2 and SH3 binding sites, which
Wolfgang Scholz +2 more
core +1 more source