Results 71 to 80 of about 4,512 (151)
The docking protein p130Cas regulates cell sensitivity to proteasome inhibition
BMC Biology, 2011 Background The focal adhesion protein p130Cas (Cas) activates multiple intracellular signaling pathways upon integrin or growth factor receptor ligation.
Vuori Kristiina, Zhao Ming
doaj +1 more source
Advanced Science, Volume 11, Issue 42, November 13, 2024.An FAK interacting and stabilizing lncRNA (FAISL) is identified, which binds FAK C‐terminus and prevents Calpain 2‐mediated FAK proteolysis. FAISL overexpression correlates with poor prognosis of triple negative breast cancer (TNBC) patients and resembles FAK‐induced phenotypes in TNBC cells.
Yunmei Zhang +11 more
wiley +1 more source
Functional analysis of p130cas in Drosophila development
, 2007 Cas (p130Cas, Crk-associated substrate)為分子量130千道爾頓的焦點黏附蛋白，當其酪胺酸磷酸化時可以執行訊息傳遞功能因而可以調節細胞骨架的重組及參與細胞遷移，然而目前對Cas在發育過程中所扮演腳色並不是很清楚，為了瞭解Cas在發育上的功能我們選擇使用果蠅遺傳系統來研究，優點在於果蠅基因體中只含有唯一的同源基因可以便於分析哺乳動物Cas複雜的功能 ...
Chi, Ai-Pei, 紀艾佩
core
BioEssays, Volume 46, Issue 11, November 2024.Attaching/effacing pathogens, such as enteropathogenic and enterohemorrhagic Escherichia coli, colonize host cells by triggering the assembly of actin filament‐rich pedestals beneath bacterial attachment sites. In this review we discuss the roles of different host actin‐binding and motor proteins in regulating pedestal assembly and bacterial ...
Nayden G. Naydenov +3 more
wiley +1 more source
Biology Open, 2016 Cell migration is a highly dynamic process that plays pivotal roles in both physiological and pathological processes. We have previously reported that p130Cas supports cell migration through the binding to Src as well as phosphorylation-dependent ...
Zhihai Zhao +6 more
doaj +1 more source
Reduced expression of ezrin and p130Cas following transfection with shRNA.
, 2016 ES2 and OVCAR3 ovarian carcinoma cells were transfected with shRNA containing plasmid. Reduced ezrin (T1, T2) or p130Cas (T3, T4) expression was verified by comparison with the expression in cells transfected with no plasmid (C1) and non-transfected ...
Vered Horwitz (3117960) +5 more
core +1 more source
Crosstalk of PKN3 and p130Cas/BCAR1 signaling
, 2016 Both p130Cas and PKN3 are important regulators of cellular signaling deregulation of which leads to malignant behavior of cancer cells. Recently we have found that SH3 domain of p130Cas mediates interaction with proline rich region of PKN3 suggesting ...
Dibus, Michal
core
P130Cas/bcar1 mediates zebrafish caudal vein plexus angiogenesis [PDF]
, 2020 P130CAS/BCAR1 belongs to the CAS family of adaptor proteins, with important regulatory roles in cell migration, cell cycle control, and apoptosis.
French, V +4 more
core +1 more source
The ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells
eLife, 2016 Cell migration requires the cyclical assembly and disassembly of focal adhesions. Adhesion induces phosphorylation of focal adhesion proteins, including Cas (Crk-associated substrate/p130Cas/BCAR1).
Anjali Teckchandani, Jonathan A Cooper
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PLoS Pathogens, 2016 Kaposi's sarcoma-associated herpesvirus (KSHV) binding to the endothelial cell surface heparan sulfate is followed by sequential interactions with α3β1, αVβ3 and αVβ5 integrins and Ephrin A2 receptor tyrosine kinase (EphA2R).
Binod Kumar +8 more
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