Results 21 to 30 of about 4,512 (151)

p130Cas over-expression impairs mammary branching morphogenesis in response to estrogen and EGF. [PDF]

PLoS ONE, 2012
p130Cas adaptor protein regulates basic processes such as cell cycle control, survival and migration. p130Cas over-expression has been related to mammary gland transformation, however the in vivo consequences of p130Cas over-expression during mammary ...
Maria del Pilar Camacho Leal, Alessandra Pincini, Giusy Tornillo, Elisa Fiorito, Brigitte Bisaro, Elisa Di Luca, Emilia Turco, Paola Defilippi, Sara Cabodi   +8 more
doaj   +1 more source

Endothelial p130cas confers resistance to anti-angiogenesis therapy

Cell Reports, 2022
Summary: Anti-angiogenic therapies, such as anti-VEGF antibodies (AVAs), have shown promise in clinical settings. However, adaptive resistance to such therapies occurs frequently.
Yunfei Wen, Anca Chelariu-Raicu, Sujanitha Umamaheswaran, Alpa M. Nick, Elaine Stur, Pahul Hanjra, Dahai Jiang, Nicholas B. Jennings, Xiuhui Chen, Sara Corvigno, Deanna Glassman, Gabriel Lopez-Berestein, Jinsong Liu, Mien-Chie Hung, Anil K. Sood   +14 more
doaj   +1 more source

p130Cas is an essential transducer element in ErbB2 transformation [PDF]

, 2010
The ErbB2 oncogene is often overexpressed in breast tumors and associated with poor clinical outcome. p130Cas represents a nodal scaffold protein regulating cell survival, migration, and proliferation in normal and pathological cells. The functional role
Iezzi, M., Defilippi, P., Montani, Maura, Amici, A., Montani, M., Camacho-Leal, Maria del Pilar, Tinnirello, Agata, Cojoca, R., Cabodi, S., Defilippi, Paola, Forni, Guido, Tinnirello, A., Turco, Emilia, Forni, G., Iezzi, Manuela, Tornillo, G., Eva, A., Di Stefano, P., Tarone, Guido, Muthuswamy, Senthil K., Camacho-Leal, M. D., Tornillo, Giusy, Bisaro, Brigitte, Muthuswamy, S. K., Eva, Alessandra, Di Stefano, Paola, Turco, E., Tarone, G., Cabodi, Sara, Bisaro, B., Amici, Augusto, Cojoca, Rodica   +31 more
core   +3 more sources

Regulation of p130Cas/BCAR1 Expression in Tamoxifen-Sensitive and Tamoxifen-Resistant Breast Cancer Cells by EGR1 and NAB2

Neoplasia: An International Journal for Oncology Research, 2012
Elevated levels of p130Cas/BCAR1 (Crk-associated substrate/breast cancer antiestrogen resistance 1) are found in aggressive breast tumors and are associated with tamoxifen resistance of mammary cancers.
Joerg Kumbrink, Kathrin H. Kirsch
doaj   +1 more source

Conditional ablation of p130Cas/BCAR1 adaptor protein impairs epidermal homeostasis by altering cell adhesion and differentiation

Cell Communication and Signaling, 2018
Background p130 Crk-associated substrate (p130CAS; also known as BCAR1) is a scaffold protein that modulates many essential cellular processes such as cell adhesion, proliferation, survival, cell migration, and intracellular signaling.
Maria del Pilar Camacho Leal, Andrea Costamagna, Beatrice Tassone, Stefania Saoncella, Matilde Simoni, Dora Natalini, Aurora Dadone, Marianna Sciortino, Emilia Turco, Paola Defilippi, Enzo Calautti, Sara Cabodi   +11 more
doaj   +1 more source

The emerin-binding transcription factor Lmo7 is regulated by association with p130Cas at focal adhesions [PDF]

PeerJ, 2013
Loss of function mutations in the nuclear inner membrane protein, emerin, cause X-linked Emery-Dreifuss muscular dystrophy (X-EDMD). X-EDMD is characterized by contractures of major tendons, skeletal muscle weakening and wasting, and cardiac conduction ...
Michele A. Wozniak, Brendon M. Baker, Christopher S. Chen, Katherine L. Wilson   +3 more
doaj   +2 more sources

Ouabain affects cell migration via Na,K-ATPase-p130cas and via nucleus-centrosome association. [PDF]

PLoS ONE, 2017
Na,K-ATPase is a membrane protein that catalyzes ATP to maintain transmembrane sodium and potassium gradients. In addition, Na,K-ATPase also acts as a signal-transducing receptor for cardiotonic steroids such as ouabain and activates a number of ...
Young Ou, Chen Xuan Pan, Jeremy Zuo, Frans A van der Hoorn   +3 more
doaj   +1 more source

Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

Cell Reports, 2021
Summary: To identify therapeutic targets for KRAS mutant pancreatic cancer, we conduct a druggable genome small interfering RNA (siRNA) screen and determine that suppression of BCAR1 sensitizes pancreatic cancer cells to ERK inhibition.
Andrew M. Waters, Tala O. Khatib, Bjoern Papke, Craig M. Goodwin, G. Aaron Hobbs, J. Nathaniel Diehl, Runying Yang, A. Cole Edwards, Katherine H. Walsh, Rita Sulahian, James M. McFarland, Kevin S. Kapner, Thomas S.K. Gilbert, Clint A. Stalnecker, Sehrish Javaid, Anna Barkovskaya, Kajal R. Grover, Priya S. Hibshman, Devon R. Blake, Antje Schaefer, Katherine M. Nowak, Jennifer E. Klomp, Tikvah K. Hayes, Michelle Kassner, Nanyun Tang, Olga Tanaseichuk, Kaisheng Chen, Yingyao Zhou, Manpreet Kalkat, Laura E. Herring, Lee M. Graves, Linda Z. Penn, Hongwei H. Yin, Andrew J. Aguirre, William C. Hahn, Adrienne D. Cox, Channing J. Der   +36 more
doaj   +1 more source

Tyrosine Y189 in the substrate domain of the adhesion docking protein NEDD9 is conserved with p130Cas Y253 and regulates NEDD9-mediated migration and focal adhesion dynamics. [PDF]

PLoS ONE, 2013
The focal adhesion docking protein NEDD9/HEF1/Cas-L regulates cell migration and cancer invasion. NEDD9 is a member of the Cas family of proteins that share conserved overall protein-protein interaction domain structure, including a substrate domain that
Jaime B Baquiran, Peta Bradbury, Geraldine M O'Neill   +2 more
doaj   +1 more source

A Role for p130Cas in Mechanotransduction [PDF]

, 2006
Focal adhesions are sites of contact between cells and the extracellular matrix. Sawada et al. (2006) now report that the mechanical stretching of cells forces p130Cas, an adaptor protein at focal adhesions, to undergo a conformational change.
Geiger, Benjamin
core   +1 more source