Results 21 to 30 of about 43,783 (161)
Frontiers in Cell and Developmental Biology, 2022 Cell-substrate adhesion is a critical aspect of many forms of cell migration. Cell adhesion to an extracellular matrix (ECM) generates traction forces necessary for efficient migration.
Julio C. Fierro Morales +2 more
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Focal Adhesion Kinase: a regulator of focal adhesion dynamics and cell movement [PDF]
Oncogene, 2000 Engagement of integrin receptors with extracellular ligands gives rise to the formation of complex multiprotein structures that link the ECM to the cytoplasmic actin cytoskeleton. These adhesive complexes are dynamic, often heterogeneous structures, varying in size and organization.
J T, Parsons +4 more
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Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration [PDF]
Scientific Reports, 2015 AbstractDirected cell migration requires dynamical control of the protein complex within focal adhesions (FAs) and this control is regulated by signaling events involving tyrosine phosphorylation. We screened the SH2 domains present in tyrosine-specific kinases and phosphatases found within FAs, including SRC, SHP1 and SHP2 and examined whether these ...
Jui-Chung Wu +6 more
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PIPKIγ regulates focal adhesion dynamics and colon cancer cell invasion. [PDF]
PLoS ONE, 2011 Focal adhesion assembly and disassembly are essential for cell migration and cancer invasion, but the detailed molecular mechanisms regulating these processes remain to be elucidated. Phosphatidylinositol phosphate kinase type Iγ (PIPKIγ) binds talin and
Zhaofei Wu +5 more
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The ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells
eLife, 2016 Cell migration requires the cyclical assembly and disassembly of focal adhesions. Adhesion induces phosphorylation of focal adhesion proteins, including Cas (Crk-associated substrate/p130Cas/BCAR1).
Anjali Teckchandani, Jonathan A Cooper
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FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING
Annual Review of Cell and Developmental Biology, 1996 ▪ Abstract Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture. They provide a structural link between the actin cytoskeleton and the extracellular matrix and are regions of signal transduction that relate to growth control.
K, Burridge, M, Chrzanowska-Wodnicka
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Functions of nonmuscle myosin II in assembly of the cellular contractile system. [PDF]
PLoS ONE, 2012 The contractile system of nonmuscle cells consists of interconnected actomyosin networks and bundles anchored to focal adhesions. The initiation of the contractile system assembly is poorly understood structurally and mechanistically, whereas system's ...
Maria Shutova +3 more
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BMC Cell Biology, 2011 Background Cell migration plays an important role in many physiological and pathological processes, including immune cell chemotaxis and cancer metastasis.
Wang Wenqi, Liu Yang, Liao Kan
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In vivo epidermal migration requires focal adhesion targeting of ACF7
Nature Communications, 2016 The spectraplakin protein ACF7 binds to actin at focal adhesions and targets microtubule plus ends to focal adhesions, promoting their disassembly. Here the authors reveal that ACF7 is phosphorylated by Src/FAK, and this regulates actin binding and focal
Jiping Yue +11 more
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Vinculin expression in MC3T3-E1 cells in response to mechanical stimulus
Data in Brief, 2016 Loading frequency is known to influence the expression of the focal adhesions of the adherent cells. A small cyclical tensile force was transmitted to mouse pre-osteoblast MC3T3-E1 cells through PDMS substrates of varying stiffness.
J.J. Cora-Cruz +2 more
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