Results 21 to 30 of about 386,087 (253)
Frontiers in Cell and Developmental Biology, 2022 Cell-substrate adhesion is a critical aspect of many forms of cell migration. Cell adhesion to an extracellular matrix (ECM) generates traction forces necessary for efficient migration.
Julio C. Fierro Morales +2 more
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Growth-factor-induced, persistent fibroblast migration is mediated by mechanical insulation of cell front and back [PDF]
, 2014 Cell migration is a crucial process during development, the immune response and wound healing. As a consequence, aberrant cell migration can lead to tumor metastasis or autoimmune disorders.
Martin, Katrin
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Multimodal Microscopy of Focal Adhesions [PDF]
, 2020 Through the systematic application of various advanced light microscopy techniques, including super-resolution microscopy, we have described in greater detail the dynamic structure of focal adhesions, protein complexes through which cells attach to a ...
Legerstee, K. (Karin)
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PIPKIγ regulates focal adhesion dynamics and colon cancer cell invasion. [PDF]
PLoS ONE, 2011 Focal adhesion assembly and disassembly are essential for cell migration and cancer invasion, but the detailed molecular mechanisms regulating these processes remain to be elucidated. Phosphatidylinositol phosphate kinase type Iγ (PIPKIγ) binds talin and
Zhaofei Wu +5 more
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The ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells
eLife, 2016 Cell migration requires the cyclical assembly and disassembly of focal adhesions. Adhesion induces phosphorylation of focal adhesion proteins, including Cas (Crk-associated substrate/p130Cas/BCAR1).
Anjali Teckchandani, Jonathan A Cooper
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Focal adhesions, contractility, and signaling [PDF]
, 1996 Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture. They provide a structural link between the actin cytoskeleton and the extracellular matrix and are regions of signal transduction that ...
Chrzanowska-Wodnicka, Magdalena +1 more
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Functions of nonmuscle myosin II in assembly of the cellular contractile system. [PDF]
PLoS ONE, 2012 The contractile system of nonmuscle cells consists of interconnected actomyosin networks and bundles anchored to focal adhesions. The initiation of the contractile system assembly is poorly understood structurally and mechanistically, whereas system's ...
Maria Shutova +3 more
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BMC Cell Biology, 2011 Background Cell migration plays an important role in many physiological and pathological processes, including immune cell chemotaxis and cancer metastasis.
Wang Wenqi, Liu Yang, Liao Kan
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Cbl-associated protein is tyrosine phosphorylated by c-Abl and c-Src kinases [PDF]
, 2009 Background: The c-Cbl-associated protein (CAP), also known as ponsin, localizes to focal adhesions and stress fibers and is involved in signaling events.
Tomasovic, Ana +11 more
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In vivo epidermal migration requires focal adhesion targeting of ACF7
Nature Communications, 2016 The spectraplakin protein ACF7 binds to actin at focal adhesions and targets microtubule plus ends to focal adhesions, promoting their disassembly. Here the authors reveal that ACF7 is phosphorylated by Src/FAK, and this regulates actin binding and focal
Jiping Yue +11 more
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