Phosphorylated paxillin and phosphorylated FAK constitute subregions within focal adhesions [PDF]
, 2022 Integrin-mediated adhesions are convergence points for multiple signaling pathways. Their inner structure and diverse functions can be studied with super-resolution microscopy.
Bachmann, Michael +4 more
core +1 more source
Paxillin: A Hub for Mechano-Transduction from the β3 Integrin-Talin-Kindlin Axis
Frontiers in Cell and Developmental Biology, 2022 Focal adhesions are specialized integrin-dependent adhesion complexes, which ensure cell anchoring to the extracellular matrix. Focal adhesions also function as mechano-signaling platforms by perceiving and integrating diverse physical and (bio)chemical ...
Marta Ripamonti +2 more
doaj +1 more source
α-Actinin-4 enhances colorectal cancer cell invasion by suppressing focal adhesion maturation.
PLoS ONE, 2015 α-Actinins (ACTNs) are known to crosslink actin filaments at focal adhesions in migrating cells. Among the four isoforms of mammalian ACTNs, ACTN1 and ACTN4 are ubiquitously expressed.
Miki Fukumoto +3 more
doaj +1 more source
Modulation of cell-matrix adhesions to affect mechanotransduction [PDF]
, 2010 In cultured fibroblasts three types of cell-matrix adhesion with specific cellular localization and protein composition can be distinguished: focal complexes, focal adhesions and fibrillar adhesions.
Lutz, Roman
core +1 more source
Center or periphery? Modeling the effects of focal adhesion placement during cell spreading.
PLoS ONE, 2017 Focal adhesions are often observed at the cell's periphery. We provide an explanation for this observation using a system-level mathematical model of a cell interacting with a two-dimensional substrate.
Magdalena A Stolarska +1 more
doaj +1 more source
Protein dynamics at invadopodia control invasion–migration transitions in melanoma cells
Cell Death and Disease, 2023 Cell invasion is a highly complex process that requires the coordination of cell migration and degradation of the extracellular matrix. In melanoma cells, as in many highly invasive cancer cell types these processes are driven by the regulated formation ...
Marlène Legrand +9 more
doaj +1 more source
Hax1 regulate focal adhesion dynamics through IQGAP1
Cell Communication and Signaling, 2023 Cell migration is a highly orchestrated process requiring the coordination between the cytoskeleton, cell membrane and extracellular matrix adhesions. Our previous study demonstrated that Hax1 interacts with EB2, a microtubule end-binding protein, and ...
Xinyi Ren +5 more
doaj +1 more source
Cells assemble invadopodia-like structures and invade into matrigel in a matrix metalloprotease dependent manner in the circular invasion assay [PDF]
, 2012 The ability of tumor cells to invade is one of the hallmarks of the metastatic phenotype. To elucidate the mechanisms by which tumor cells acquire an invasive phenotype, in vitro assays have been developed that mimic the process of cancer cell invasion ...
Yu, X. +7 more
core +1 more source
αV-Integrins Are Required for Mechanotransduction in MDCK Epithelial Cells [PDF]
, 2013 The properties of epithelial cells within tissues are regulated by their immediate microenvironment, which consists of neighboring cells and the extracellular matrix (ECM).
Muller, Daniel J +42 more
core +2 more sources
Stress fibers and focal adhesions.
, 2021 Confocal fluorescence microscopy images of an MRC5 cell stained for A) actin filaments (phalloidin) and B) focal adhesions (paxillin). C) Merged color image of the cell with actin filaments in magenta and adhesions in green. All images are of the ventral
Andreas Primeßnig (11419599) +4 more
core +1 more source