Results 51 to 60 of about 74,823 (197)

Investigation of the limits of nanoscale filopodial interactions [PDF]

, 2014
Mesenchymal stem cells are sensitive to changes in feature height, order and spacing. We had previously noted that there was an inverse relationship between osteoinductive potential and feature height on 15-, 55- and 90 nm-high titania nanopillars, with ...
Dalby, Matthew J., McNamara, Laura E., Meek, R.M. Dominic, Seunarine, Krishna, Sjostrom, Terje, Su, Bo   +5 more
core   +2 more sources

Reversal of aging-induced increases in aortic stiffness by targeting cytoskeletal protein-protein interfaces [PDF]

, 2018
Background: The proximal aorta normally functions as a critical shock absorber that protects small downstream vessels from damage by pressure and flow pulsatility generated by the heart during systole.
AortaGen Consortium, the, Bekaert, Sofie, Chiu, Joanna G, De Backer, Gui, De Bacquer, Dirk, De Buyzere, Marc, De Meyer, Tim, Gao, Yuan Z, Gillebert, Thierry, Leavis, Paul, Li, Qian, Mitchell, GF, Morgan, Kathleen G, Nicholson, Christopher J, Porter, Tyrone, Rietzschel, Ernst, Saphirstein, Robert J, Segers, Patrick, Singh, Kuldeep, Van Bortel, Lucas, Verwoert, Germaine C   +20 more
core   +5 more sources

Development of Novel Flow Chamber to Study Endothelial Cell Morphology: Effects of Shear Flow with Uniform Spatial Gradient on Distribution of Focal Adhesion

Journal of Biomechanical Science and Engineering, 2013
Fluid shear stress (SS) is well known to cause morphological changes in vascular endothelial cells (ECs) accompanied by alteration in actin cytoskeletal structure and distribution of focal adhesions.
Daisuke YOSHINO, Naoya SAKAMOTO, Keita TAKAHASHI, Eri INOUE, Masaaki SATO   +4 more
doaj   +1 more source

High-resolution quantification of focal adhesion spatiotemporal dynamics in living cells. [PDF]

PLoS ONE, 2011
Focal adhesions (FAs) are macromolecular complexes that provide a linkage between the cell and its external environment. In a motile cell, focal adhesions change size and position to govern cell migration, through the dynamic processes of assembly and ...
Mathew E Berginski, Eric A Vitriol, Klaus M Hahn, Shawn M Gomez   +3 more
doaj   +1 more source

Electrical Stimulation Causes Activation of c-Src and Focal Adhesion Kinase in Fibroblasts

Biology and Life Sciences Forum, 2023
Stimulation of the skin and muscles in the field of acupuncture and moxibustion has been shown to increase local blood flow and metabolism or maintain the body in a sustained healthy state.
Kazuo Katoh
doaj   +1 more source

Focal adhesion kinase: Insight into molecular roles and functions in hepatocellular carcinoma [PDF]

, 2017
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Due to the high incidence of post-operative recurrence after current treatments, the identification of new and more effective drugs is required.
Alisi, Anna, Crudele, Annalisa, Gnani, Daniela, Panera, Nadia, Romito, Ilaria   +4 more
core   +2 more sources

Distribution of Cytoskeletal Components in Endothelial Cells in the Guinea Pig Renal Artery

International Journal of Cell Biology, 2012
The cytoskeletal components of endothelial cells in the renal artery were examined by analysis of en face preparations under confocal laser scanning microscopy. Renal arterial endothelial cells were shown to be elongated along the direction of blood flow,
Kazuo Katoh, Yasuko Noda
doaj   +1 more source

Canonical and non-canonical integrin-based adhesions dynamically interconvert

Nature Communications
Adhesions are critical for anchoring cells in their environment, as signaling platforms and for cell migration. In line with these diverse functions different types of cell-matrix adhesions have been described.
Fabian Lukas, Claudia Matthaeus, Tania López-Hernández, Ines Lahmann, Nicole Schultz, Martin Lehmann, Dmytro Puchkov, Jan Pielage, Volker Haucke, Tanja Maritzen   +9 more
doaj   +1 more source

Semaphorin 3A Increases FAK Phosphorylation at Focal Adhesions to Modulate MDA-MB-231 Cell Migration and Spreading on Different Substratum Concentrations

International Journal of Breast Cancer, 2017
Interactions between integrin-mediated adhesions and the extracellular matrix (ECM) are important regulators of cell migration and spreading. However, mechanisms by which extracellular ligands regulate cell migration and spreading in response to changes ...
Scott Gehler, Frances V. Compere, Alex M. Miller   +2 more
doaj   +1 more source

Diverse cell junctions with unique molecular composition in tissues of a sponge (Porifera)

EvoDevo, 2019
The integrity and organization of animal tissues depend upon specialized protein complexes that mediate adhesion between cells with each other (cadherin-based adherens junctions), and with the extracellular matrix (integrin-based focal adhesions ...
Jennyfer M. Mitchell, Scott A. Nichols
doaj   +1 more source