Results 71 to 80 of about 74,823 (197)

Loss of the Essential Autophagy Regulators FIP200 or Atg5 Leads to Distinct Effects on Focal Adhesion Composition and Organization

Frontiers in Cell and Developmental Biology, 2020
Autophagy is an essential catabolic intracellular pathway that maintains homeostasis by degrading long-lived proteins, damaged organelles, and provides an energy source during nutrient starvation.
Emelia A. Assar, David A. Tumbarello
doaj   +1 more source

MAGI1 localizes to mature focal adhesion and modulates endothelial cell adhesion, migration and angiogenesis

Cell Adhesion & Migration, 2021
MAGI1 is an intracellular adaptor protein that stabilizes cell junctions and regulates epithelial and endothelial integrity. Here, we report that that in endothelial cells MAGI1 colocalizes with paxillin, β3-integrin, talin 1, tensin 3 and α-4-actinin at
Begoña Alday-Parejo, Kedar Ghimire, Oriana Coquoz, Gioele W. Albisetti, Luca Tamò, Jelena Zaric, Jimmy Stalin, Curzio Rüegg   +7 more
doaj   +1 more source

Contractile stresses in cohesive cell layers on finite-thickness substrates

, 2012
Using a minimal model of cells or cohesive cell layers as continuum active elastic media, we examine the effect of substrate thickness and stiffness on traction forces exerted by strongly adhering cells. We obtain a simple expression for the length scale
J. Barber, L. D. Landau, M. Cristina Marchetti, Shiladitya Banerjee   +3 more
core   +1 more source

Correlation of cellular traction forces and dissociation kinetics of adhesive protein zyxin revealed by multi-parametric live cell microscopy.

PLoS ONE, 2021
Cells exert traction forces on the extracellular matrix to which they are adhered through the formation of focal adhesions. Spatial-temporal regulation of traction forces is crucial in cell adhesion, migration, cellular division, and remodeling of the ...
Lorena Sigaut, Micaela Bianchi, Catalina von Bilderling, Lía Isabel Pietrasanta   +3 more
doaj   +1 more source

Phosphoinositide Conversion Inactivates R‐RAS and Drives Metastases in Breast Cancer

Advanced Science, 2022
Breast cancer is the most prevalent cancer and a major cause of death in women worldwide. Although early diagnosis and therapeutic intervention significantly improve patient survival rate, metastasis still accounts for most deaths.
Huayi Li, Lorenzo Prever, Myriam Y. Hsu, Wen‐Ting Lo, Jean Piero Margaria, Maria Chiara De Santis, Cristina Zanini, Marco Forni, Francesco Novelli, Salvatore Pece, Pier Paolo Di Fiore, Paolo Ettore Porporato, Miriam Martini, Hassane Belabed, Marc Nazare, Volker Haucke, Federico Gulluni, Emilio Hirsch   +17 more
doaj   +1 more source

Elastic interactions of active cells with soft materials

, 2003
Anchorage-dependent cells collect information on the mechanical properties of the environment through their contractile machineries and use this information to position and orient themselves.
A.K. Harris, A.K. Harris, B. Geiger, B. Geiger, C.-M. Lo, C.G. Galbraith, D. Choquet, D. Riveline, F. Grinnell, G.F. Oster, H. Wagner, I. B. Bischofs, I.B. Bischofs, J.L. Tan, J.P. Butler, J.Y. Wong, K.H. Lau, L.J. Walpole, M. Dembo, M. Dembo, M.E. Chicurel, N. Phan-Thien, N. Wang, N.Q. Balaban, P. Lenz, R. Siems, R.-P. Hirsekorn, R.A. Simha, R.D. Mindlin, R.J. Pelham, S. A. Safran, S. Huang, S. Ramaswamy, S.A. Safran, T. Tlusty, U. S. Schwarz, U.S. Schwarz, U.S. Schwarz, V.H. Barocas   +38 more
core   +1 more source

Phosphorylation of p130Cas initiates Rac activation and membrane ruffling [PDF]

, 2008
Background Non-receptor tyrosine kinases (NTKs) regulate physiological processes such as cell migration, differentiation, proliferation, and survival by interacting with and phosphorylating a large number of substrates simultaneously.
Alok Sharma, Bruce J Mayer, DA Lauffenburger, AJ Ridley, M Vicente-Manzanares, S Even-Ram, A Hall, PG Charest, YL Wang, RA Klinghoffer, D Ilic, AJ Koleske, H Honda, M Hagel, PY Chan, MD Schaller, MA Schwartz, LA Cary, BS Cobb, TR Polte, DD Schlaepfer, DD Schlaepfer, LA Cary, RL Klemke, RL Klemke, DA Cheresh, MD Welch, G Giannone, AJ Ridley, RL Klemke, SY Cho, SY Cho, AJ Ridley, H Miki, S Eden, MT Brown, SM Thomas, J Schlessinger, AB Reynolds, M Matsuda, R Sakai, R Sakai, M Auvinen, T Nakamoto, LA Petch, PJ Ruest, LA Cary, PM Fonseca, SM Bockholt, K Vuori, K Fujiwara, A Sharma, A Sharma, KM Arndt, K Machida, V Petit, SK Sastry, E Zamir, I Kaverina, MT Harte, SH Lo, V Benard, WE Allen, D Cox, AH Bouton, M Tamada, Y Sawada, H Honda, J Leng, CM Wells, R Pankov, GM Rivera, GM Rivera   +72 more
core   +2 more sources

The Focal Adhesion Analysis Server: a web tool for analyzing focal adhesion dynamics [v1; ref status: indexed, http://f1000r.es/yc]

F1000Research, 2013
The Focal Adhesion Analysis Server (FAAS) is a web-based implementation of a set of computer vision algorithms designed to quantify the behavior of focal adhesions in cells imaged in 2D cultures.
Matthew E Berginski, Shawn M Gomez
doaj   +1 more source

HAb18G/CD147 regulates vinculin-mediated focal adhesion and cytoskeleton organization in cultured human hepatocellular carcinoma cells. [PDF]

PLoS ONE, 2014
Focal adhesions (FAs), integrin-mediated macromolecular complexes located at the cell membrane extracellular interface, have been shown to regulate cell adhesion and migration.
Qiang Liang, Qing Han, Wan Huang, Gang Nan, Bao-Qing Xu, Jian-Li Jiang, Zhi-Nan Chen   +6 more
doaj   +1 more source

αV-Integrins Are Required for Mechanotransduction in MDCK Epithelial Cells [PDF]

, 2013
The properties of epithelial cells within tissues are regulated by their immediate microenvironment, which consists of neighboring cells and the extracellular matrix (ECM).
Engler, Adam J., Friedrichs, Jens, Manninen, Aki, Matlin, Karl S., Moyano, Jose V., Muller, Daniel J., Myllymäki, Satu M., Strohmeyer, Nico, Teräväinen, Terhi P., Wu, Chuanyue   +9 more
core   +3 more sources