Results 81 to 90 of about 74,823 (197)
Focal adhesion kinase and cancer.
Histology and histopathology, 2009 Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that resides at the sites of integrin clustering, known as focal adhesions. The FAK protein has a molecular mass of 125kDa and is encoded by the FAK gene located on human chromosome 8q24.
Golubovskaya1, Vita M. +2 more
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Galectin-3 Overrides PTRF/Cavin-1 Reduction of PC3 Prostate Cancer Cell Migration. [PDF]
PLoS ONE, 2015 Expression of Caveolin-1 (Cav1), a key component of cell surface caveolae, is elevated in prostate cancer (PCa) and associated with PCa metastasis and a poor prognosis for PCa patients.
Fanrui Meng +2 more
doaj +1 more source
Designing stem cell niches for differentiation and self-renewal [PDF]
, 2018 Mesenchymal stem cells, characterized by their ability to differentiate into skeletal tissues and self-renew, hold great promise for both regenerative medicine and novel therapeutic discovery. However, their regenerative capacity is retained only when in
Dalby, Matthew J. +2 more
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Myosin IIA-mediated forces regulate multicellular integrity during vascular sprouting [PDF]
, 2019 Angiogenic sprouting is a critical process involved in vascular network formation within tissues. During sprouting, tip cells and ensuing stalk cells migrate collectively into the extracellular matrix while preserving cell-cell junctions, forming patent ...
Chen, Christopher S. +10 more
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, 2017 We develop a method to reconstruct, from measured displacements of an underlying elastic substrate, the spatially dependent forces that cells or tissues impart on it.
Chang, Joshua C., Chou, Tom, Liu, Yanli
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Actin Dynamics Associated with Focal Adhesions
International Journal of Cell Biology, 2012 Cell-matrix adhesion plays a major role during cell migration. Proteins from adhesion structures connect the extracellular matrix to the actin cytoskeleton, allowing the growing actin network to push the plasma membrane and the contractile cables (stress
Corina Ciobanasu +2 more
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Step-by-step quantitative analysis of focal adhesions
MethodsX, 2014 Focal adhesions (FAs) are specialized adhesive structures which serve as cellular communication units between cells and the surrounding extracellular matrix. FAs are involved in signal transduction and actin cytoskeleton organization.
Utku Horzum +2 more
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SNX 9 interacts with dynamin 2 and N-wasp to regulate focal adhesion disassembly and cell migration [PDF]
, 2014 The turnover of focal adhesions is essential for normal cell migration and tumor invasion, but the underlying mechanisms are poorly understood. We have previously shown that the disassembly of focal adhesions occurs by endocytosis of activated ...
Chao, W. T. +2 more
core
Signaling through focal adhesion kinase
Progress in Biophysics and Molecular Biology, 1999 Integrin receptor binding to extracellular matrix proteins generates intracellular signals via enhanced tyrosine phosphorylation events that are important for cell growth, survival, and migration. This review will focus on the functions of the focal adhesion kinase (FAK) protein-tyrosine kinase (PTK) and its role in linking integrin receptors to ...
Schlaepfer, David D. +2 more
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, 2020 This is about the functions,regulations,structure and inhibition of ...
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