Results 91 to 100 of about 74,823 (197)
Force-induced recruitment of cten along keratin network in epithelial cells. [PDF]
, 2019 The cytoskeleton provides structural integrity to cells and serves as a key component in mechanotransduction. Tensins are thought to provide a force-bearing linkage between integrins and the actin cytoskeleton; yet, direct evidence of tensin's role in ...
Cheah, Joleen S +4 more
core
A practical review on the measurement tools for cellular adhesion force
, 2019 Cell cell and cell matrix adhesions are fundamental in all multicellular organisms. They play a key role in cellular growth, differentiation, pattern formation and migration.
Gerecsei, Tamas +5 more
core +1 more source
Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation
eLifeLiquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form LLPS, which govern adhesion dynamics and related cell
Abhishek Kumar +2 more
doaj +1 more source
Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death. [PDF]
, 2012 The altered metabolism of cancer can render cells dependent on the availability of metabolic substrates for viability. Investigating the signaling mechanisms underlying cell death in cells dependent upon glucose for survival, we demonstrate that glucose ...
Graeber, Thomas G +12 more
core
Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. [PDF]
, 2012 Migrating cells acquire front-rear polarity with a leading edge and a trailing tail for directional movement. The Rac exchange factor Tiam1 participates in polarized cell migration with the PAR complex of PAR3, PAR6, and atypical protein kinase C ...
Collard, John G +14 more
core
Focal adhesions: What's new inside
Developmental Biology, 2006 The cytoplasmic side of focal adhesions is comprised of large molecular complexes that link transmembrane receptors, such as integrins, to the actin cytoskeleton and mediate signals modulating cell attachment, migration, proliferation, differentiation, and gene expression.
openaire +2 more sources
Unanchoring integrins in focal adhesions
Nature Cell Biology, 2012 Focal adhesions are large structures through which integrins and scaffold proteins link the actin cytoskeleton to the extracellular matrix. A detailed analysis of integrin dynamics now indicates that focal-adhesion-associated integrins constantly switch between active and immobilized, and unbound and free-diffusing states, with different fibronectin ...
openaire +2 more sources
Emerging S100A11 roles: Regulation of focal adhesion dynamics and mechanosensing
Cell Structure and FunctionS100A11 is a small calcium-binding protein that has been studied in the context of growth regulation and membrane repair. However, it has recently been linked to the disassembly of focal adhesions.
Tareg Omer Mohammed +2 more
doaj +1 more source
Studies of focal adhesion assembly
Biochemical Society Transactions, 2008 Recent studies of some proteins involved in the formation of focal adhesions are described. These include fibronectin, integrins, talin, Dok1 and filamin. Emphasis is placed on features that facilitate regulated assembly of complexes; these include a modular construction and flexible regions that provide interaction sites whose affinity can be adjusted
openaire +3 more sources