Results 1 to 10 of about 25,880 (235)

Inhibition of focal adhesion kinase enhances antitumor response of radiation therapy in pancreatic cancer through CD8+ T cells

Cancer Biology & Medicine, 2021
Objective: Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy, due in large part to its resistance to conventional therapies, including radiotherapy (RT).
Arsen Osipov, Alex B. Blair, Juliane Liberto, Jianxin Wang, Keyu Li, Brian Herbst, Yao Xu, Shiqi Li, Nan Niu, Rufiaat Rashid, Ding Ding, Yanan Liu, Zaiqi Wang, Christopher L. Wolfgang, Richard A. Burkhart, Daniel Laheru, Lei Zheng   +16 more
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A role for the protein tyrosine phosphatase CD45 in macrophage adhesion through the regulation of paxillin degradation. [PDF]

PLoS ONE, 2013
CD45 is a protein tyrosine phosphatase expressed on all cells of hematopoietic origin that is known to regulate Src family kinases. In macrophages, the absence of CD45 has been linked to defects in adhesion, however the molecular mechanisms involved ...
Joëlle St-Pierre, Hanne L Ostergaard
doaj   +1 more source

Regulation of Fibroblast Cell Polarity by Src Tyrosine Kinase

Biomedicines, 2021
Src protein tyrosine kinases (SFKs) are a family of nonreceptor tyrosine kinases that are localized beneath the plasma membrane and are activated during cell adhesion, migration, and elongation.
Kazuo Katoh
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PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility

Cells, 2020
Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associated with poor prognosis of cancer patients.
Hsin-Wei Jen, De-Leung Gu, Yaw-Dong Lang, Yuh-Shan Jou   +3 more
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SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. [PDF]

PLoS ONE, 2014
Reactive oxygen species (ROS) regulate diverse cellular functions by triggering signal transduction events, such as Src and mitogen-activated protein (MAP) kinases.
Ara Jo, Hyunju Park, Sung-Hee Lee, So-Hee Ahn, Hee Ja Kim, Eun-Mi Park, Youn-Hee Choi   +6 more
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CB1 Cannabinoid Receptors Stimulate Gβγ-GRK2-Mediated FAK Phosphorylation at Tyrosine 925 to Regulate ERK Activation Involving Neuronal Focal Adhesions

Frontiers in Cellular Neuroscience, 2020
CB1 cannabinoid receptors (CB1) are abundantly expressed in the nervous system where they regulate focal adhesion kinase (FAK) and the mitogen-activated protein kinases (MAPK) extracellular signal-regulated kinase 1 and 2 (ERK1/2).
George D. Dalton, Skyla T. Carney, Jamie D. Marshburn, Derek C. Norford, Allyn C. Howlett   +4 more
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DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction

Journal of Biomedical Science, 2022
Background Tight junctions (TJ) are multi-protein complexes that hold epithelial cells together and form structural and functional barriers for maintaining proper biological activities.
Hsiao-Chin Chou, Chun-Mei Cheng, Chi-Hwa Yang, Tzu-Yin Lin, Ya-Wen Liu, Tse-Hua Tan, Yi-Rong Chen   +6 more
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Angiotensin II Type I Receptor (AT1R): The Gate towards COVID-19-Associated Diseases

Molecules, 2022
The binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein to its cellular receptor, the angiotensin-converting enzyme 2 (ACE2), causes its downregulation, which subsequently leads to the dysregulation of the renin–
George El-Arif, Shaymaa Khazaal, Antonella Farhat, Julien Harb, Cédric Annweiler, Yingliang Wu, Zhijian Cao, Hervé Kovacic, Ziad Abi Khattar, Ziad Fajloun, Jean-Marc Sabatier   +10 more
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Prolactin-induced protein (PIP) regulates proliferation of luminal A type breast cancer cells in an estrogen-independent manner. [PDF]

PLoS ONE, 2014
Prolactin-induced Protein (PIP), an aspartyl protease unessential for normal mammalian cell function, is required for the proliferation and invasion of some breast cancer (BCa) cell types.
Sanjeev K Baniwal, Nyam-Osor Chimge, V Craig Jordan, Debu Tripathy, Baruch Frenkel   +4 more
doaj   +1 more source

Recruitment of focal adhesion kinase and paxillin to β1 integrin promotes cancer cell migration via mitogen activated protein kinase activation

BMC Cancer, 2004
Background Integrin-extracellular matrix interactions activate signaling cascades such as mitogen activated protein kinases (MAPK). Integrin binding to extracellular matrix increases tyrosine phosphorylation of focal adhesion kinase (FAK).
Ohannessian Arthur, Crowe David L
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