Results 1 to 10 of about 52,035 (209)

SIPA1 boosts migration and proliferation, and blocks apoptosis of glioma by activating the phosphorylation of the FAK signaling pathway [PDF]

Journal of Medical Biochemistry, 2022
Background: We aimed to analyze the regulatory effects of SIPA1 (signal-induced proliferation-associated protein 1) on glioma progression and the dominant signaling pathway.
Du Yuan, Li Shenglan, Zhou Tong, Zhao Jing, Liu Jiguang   +4 more
doaj   +1 more source

LRG1 Is Involved in the Progression of Ovarian Cancer via Modulating FAK/AKT Signaling Pathway

Frontiers in Bioscience-Landmark, 2023
Background: Rapid progression and early metastasis remain the main cause of high mortality in epithelial ovarian cancer (EOC) patients. The objective of this study was to explore the mechanisms of EOC progression and detect the function of leucine-rich ...
Dongling Wu, Weiwei Xie, Xin Chen, Huizhen Sun   +3 more
doaj   +1 more source

Roles of non-receptor tyrosine kinases in pathogenesis and treatment of depression [PDF]

Journal of Integrative Neuroscience, 2022
Major depressive disorder is a chronic psychiatric disease with a high prevalence. Brain mechanisms for depression at cellular and molecular levels are far from clear. Increasing evidence from clinical and preclinical studies reveals critical roles of
John Q. Wang, Justin D. Derges, Alaya Bodepudi, Nikhila Pokala, Li-Min Mao   +4 more
doaj   +1 more source

Wnt5b integrates Fak1a to mediate gastrulation cell movements via Rac1 and Cdc42 [PDF]

Open Biology, 2020
Focal adhesion kinase (FAK) mediates vital cellular pathways during development. Despite its necessity, how FAK regulates and integrates with other signals during early embryogenesis remains poorly understood.
I-Chen Hung, Tsung-Ming Chen, Jing-Ping Lin, Yu-Ling Tai, Tang-Long Shen, Shyh-Jye Lee   +5 more
doaj   +1 more source

Cell contractility and focal adhesion kinase control circumferential arterial stiffness

Vascular Biology, 2022
Arterial stiffening is a hallmark of aging and cardiovascular disease. While it is well established that vascular smooth muscle cells (SMCs) contribute to arterial stiffness by synthesizing and remodeling the arterial extracellular matrix, the direct ...
Emilia Roberts, Tina Xu, Richard K Assoian   +2 more
doaj   +1 more source

FAK-Dependent Cell Motility and Cell Elongation

Cells, 2020
Fibroblastic cells show specific substrate selectivity for typical cell−substrate adhesion. However, focal adhesion kinase (FAK) contributes to controlling the regulation of orientation and polarity.
Kazuo Katoh
doaj   +1 more source

Focused low-intensity pulsed ultrasound upregulates Vimentin protein expression to inhibit chondrocyte apoptosis

陆军军医大学学报, 2023
Objective To investigate the molecular mechanism of focused low-intensity pulsed ultrasound (FLIPUS) to inhibit chondrocyte apoptosis through mechanical effects.
LI Dongqian, YE Haixia, YU Lehua, JIA Lang   +3 more
doaj   +1 more source

FAK PROTAC Inhibits Ovarian Tumor Growth and Metastasis by Disrupting Kinase Dependent and Independent Pathways

Frontiers in Oncology, 2022
Focal adhesion kinase (FAK) is highly expressed in a variety of human cancers and is a target for cancer therapy. Since FAK kinase inhibitors only block the kinase activity of FAK, they are not highly effective in clinical trials. FAK also functions as a
Xueyun Huo, Xueyun Huo, Xueyun Huo, Wenjing Zhang, Guannan Zhao, Guannan Zhao, Zhenwen Chen, Peixin Dong, Hidemichi Watari, Ramesh Narayanan, Ramesh Narayanan, Todd D. Tillmanns, Lawrence M. Pfeffer, Lawrence M. Pfeffer, Junming Yue, Junming Yue   +15 more
doaj   +1 more source

Complement receptor 3 mediates Aspergillus fumigatus internalization into alveolar epithelial cells with the increase of intracellular phosphatidic acid by activating FAK

Virulence, 2021
Complement receptor 3 (CD11b/CD18) is an important receptor that mediates adhesion, phagocytosis and chemotaxis in various immunocytes. The conidia of the medically-important pathogenic fungus, Aspergillus fumigatus can be internalized into alveolar ...
Xuelin Han, Xueting Su, Zhiqian Li, Yanxi Liu, Shuo Wang, Miao Zhu, Changjian Zhang, Fan Yang, Jingya Zhao, Xianping Li, Fangyan Chen, Li Han   +11 more
doaj   +1 more source

Ubiquitin-conjugating enzyme E2T promotes tumor stem cell characteristics and migration of cervical cancer cells by regulating the GRP78/FAK pathway

Open Life Sciences, 2021
Ubiquitin-conjugating enzyme E2T (UBE2T) functions as an E2 ubiquitin-conjugating enzyme in the ubiquitin-proteasome degradation system and mediates cellular processes, such as cell cycle, proliferation, and differentiation.
Liu YanMei, Ji WenLi, Yue Na, Zhou Weidong   +3 more
doaj   +1 more source