Results 21 to 30 of about 52,035 (209)
Focal adhesion kinase: from biological functions to therapeutic strategies
Experimental Hematology & Oncology, 2023 Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital participant in primary cellular functions, such as proliferation, survival, migration, and invasion. In addition, FAK regulates cancer stem cell activities and contributes
Ximin Tan +5 more
doaj +1 more source
Leptin induces cell migration and invasion in a FAK-Src-dependent manner in breast cancer cells
Endocrine Connections, 2019 Breast cancer is the most common invasive neoplasia, and the second leading cause of the cancer deaths in women worldwide. Mammary tumorigenesis is severely linked to obesity, one potential connection is leptin. Leptin is a hormone secreted by adipocytes,
Juan Carlos Juárez-Cruz +9 more
doaj +1 more source
FAK-mediated mechanotransduction in skeletal regeneration [PDF]
, 2007 The majority of cells are equipped to detect and decipher physical stimuli, and then react to these stimuli in a cell type-specific manner. Ultimately, these cellular behaviors are synchronized to produce a tissue response, but how this is achieved ...
Kim Jae-Beom +14 more
core +2 more sources
Open Life Sciences, 2019 Platelet-rich plasma (PRP) has been shown to be a beneficial growth factor for bone tissue healing and is used in implantology. The aim of this study was to investigate the effects of PRP on bone defects in rabbits.
Liu Wei +4 more
doaj +1 more source
PARCUKU: A RELIGIOUS RITUAL OF THE FAK-FAK COMMUNITY [PDF]
, 2013 Local Islam which is synonymous with the implementation of rituals is always interesting to discuss, either through free discussion or in the academic sphere, which will map out the speakers at both confronting and accommodating areas.
Yamin, Ade, Ade Yamin
core +1 more source
FAK family kinases: The Yin and Yang of cancer cell invasiveness
Molecular & Cellular Oncology, 2018 Proline-rich tyrosine kinase 2 (PYK2, also known as Pyk2) and its closely related focal adhesion kinase (FAK) modulate cancer cell invasion by coordinating the balance between focal adhesion-mediated migration and invadopodia-dependent extracellular ...
Alessandro Genna, Hava Gil-Henn
doaj +1 more source
LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2 [PDF]
, 2016 Mutation of leucine-rich repeat kinase 2 (LRRK2) causes an autosomal dominant and late-onset familial Parkinson's disease (PD). Recently, we reported that LRRK2 directly binds to and phosphorylates the threonine 474 (T474)-containing Thr-X-Arg(Lys) (TXR)
Choi, I +4 more
core +1 more source
Bone & Joint ResearchAims: Osteosarcoma is the most common primary bone malignancy among children and adolescents. We investigated whether benzamil, an amiloride analogue and sodium-calcium exchange blocker, may exhibit therapeutic potential for osteosarcoma in vitro ...
Meng-Chieh Lin +8 more
doaj +1 more source
Cell-cell and cell-matrix adhesion in survival and metastasis: Stat3 versus Akt
Biomolecular Concepts, 2015 Both cell-cell and cell-matrix adhesion are important for epithelial cell differentiation and function. Classical cadherins mediate cell to cell interactions and are potent activators of the signal transducer and activator of transcription (Stat3 ...
Niit Maximilian +6 more
doaj +1 more source
Cell Death and Disease, 2022 Acute lung injury (ALI), characterized by inflammatory damage, is a major clinical challenge. Developing specific treatment options for ALI requires the identification of novel targetable signaling pathways.
Xi Chen +9 more
doaj +1 more source