Results 31 to 40 of about 52,035 (209)

FAK inhibition disrupts tumor growth, apoptosis, and transcriptional regulation in GI-NETs

Endocrine Oncology
Background: Gastrointestinal neuroendocrine tumors (GI-NETs) are rare neoplasms with limited therapeutic options and increasing clinical incidence. Focal adhesion kinase (FAK) has been implicated in oncogenic processes across various tumor types; however,
Lara Toffoli, Angeliki Ditsiou, Luca Triboli, Victorine Hamm, Eva Moschioni, Francesca D’Este, Teresa Gagliano   +6 more
doaj   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Netrin-1 Role in Nociceptive Neuron Sprouting through Activation of DCC Signaling in a Rat Model of Bone Cancer Pain

Journal of Integrative Neuroscience
Background: Bone cancer pain (BCP) is a common primary or metastatic bone cancer complication. Netrin-1 plays an essential role in neurite elongation and pain sensitization.
Zhihao Gong, Yuxin Zhang, Wei Wang, Xin Li, Kai Wang, Xingji You, Jingxiang Wu   +6 more
doaj   +1 more source

The effect of differentiation induction on FAK and Src activity in live HMSCs visualized by FRET. [PDF]

PLoS ONE, 2013
FAK and Src signaling play important roles in cell differentiation, survival and migration. However, it remains unclear how FAK and Src activities are regulated at the initial stage of stem cell differentiation.
Xiaoling Liao, Shaoying Lu, Yiqian Wu, Wenfeng Xu, Yue Zhuo, Qin Peng, Bo Li, Ling Zhang, Yingxiao Wang   +8 more
doaj   +1 more source

Mechano-transduction to muscle protein synthesis is modulated by FAK [PDF]

, 2009
We examined the involvement of focal adhesion kinase (FAK) in mechano-regulated signalling to protein synthesis by combining muscle-targeted transgenesis with a physiological model for un- and reloading of hindlimbs.
Freyssenet, Damien, Flueck, Martin, Durieux, Anne-Cecile, Klossner, Stephan, Flück, Martin, Flueck M, Freyssenet D, Durieux AC, Klossner S   +8 more
core   +2 more sources

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

Advanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang, Haijia Xu, Xiangzhong Liu, Yi Yang, Zhanghua Li   +4 more
wiley   +1 more source

Requirement of PEA3 for transcriptional activation of FAK gene in tumor metastasis. [PDF]

PLoS ONE, 2013
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase critically involved in cancer metastasis. We found an elevation of FAK expression in highly metastatic melanoma B16F10 cells compared with its less metastatic partner B16F1 cells.
Shufeng Li, Xiaofeng Huang, Dapeng Zhang, Qilai Huang, Guoshun Pei, Lixiang Wang, Wenhui Jiang, Qingang Hu, Renxiang Tan, Zi-Chun Hua   +9 more
doaj   +1 more source

FAK-Copy-Gain Is a Predictive Marker for Sensitivity to FAK Inhibition in Breast Cancer

, 2019
Background: Cancers with copy-gain drug-target genes are excellent candidates for targeted therapy. In order to search for new predictive marker genes, we investigated the correlation between sensitivity to targeted drugs and the copy gain of candidate ...
Eun-Kyung Kang, Hyonchol Jang, Hyun-Kyoung Kim, Young-Ho Kim, Hye Won Sim, Ju-Young Seoh, Hee Yeon Kim, HyeRan Gawk, Kyeong-Man Hong, Seung-Hyun Bae, 서주영   +10 more
core   +2 more sources

Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction

Advanced Materials, EarlyView.
The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu, Alison E. John, Marc A. Fernández‐Yagüe   +2 more
wiley   +1 more source

Extracellular presentation of syntaxin4 as a potential trigger for region-specific gastrulation

Cell Structure and Function
During early embryogenesis, gastrulation occurs within a specific region of the pluripotent epiblast, where cells undergo significant changes in their context.
Sae Nozaki, Taisei Mihara, Yohei Hirai
doaj   +1 more source