Results 51 to 60 of about 52,035 (209)

The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review

Journal of Experimental & Clinical Cancer Research, 2019
FAK is a tyrosine kinase overexpressed in cancer cells and plays an important role in the progression of tumors to a malignant phenotype. Except for its typical role as a cytoplasmic kinase downstream of integrin and growth factor receptor signaling ...
Jin Zhou, Qian Yi, Liling Tang
doaj   +1 more source

P-Src distribution and interaction in FAK^-/-, wild-type FAK and FAK^I936/I998 cells.

, 2014
(A) Confocal images of fixed FAK-/-cells expressing or not (NT, non-transfected cells) wild-type or mutant FAK-GFP (left panel) and immunostained for paxillin (middle panel) or Src phopsphorylated at tyr 416 (right panel). Note the high level of P-Src at
Ken Takeda (441984), Thérèse B. Deramaudt (538784), Philippe Rondé (538786), Fanny Noulet (538785), Sophie Martin (254058), Denis Dujardin (25529), Romain Vauchelles (360387)   +6 more
core   +1 more source

Decoding Viral Transmission Dynamics in Structured Populations Using a Microfluidic Herd‐Immunity‐on‐a‐Chip Platform

Advanced Science, EarlyView.
A microfluidic Herd‐Immunity‐on‐a‐Chip experimentally recreates structured contact networks to quantify viral transmission dynamics. By controlling susceptible, infected, and non‐susceptible populations, the platform reveals how contact topology governs the reproduction number, outbreak propagation, herd‐immunity–like behavior, and intervention ...
Jiande Zhang, Narina Jung, Min‐Hyeok Kim, Wanyoung Lim, Zhenzhong Chen, Byung Mook Weon, Sungsu Park   +6 more
wiley   +1 more source

Upaya Pengembangan Diri Mahasiswa pada Asrama Putri Fak-Fak Kelurahan Heram Distrik Heram Kota Jayapura [PDF]

, 2023
Fokus upaya pengembangan diri mahasiswi dalam aspek-aspek pelatihan pembina organisasi, penyuluhan meraih sukses dan perluasan kesempatan. Rumusan masalah penelitian, yaitu: “Bagaimana Upaya Pengembangan Diri Mahasiswi Pada Asrama Putri Fak-fak ...
Kabes, Sindiana Abong
core   +1 more source

Unravelling the Distinct Phenotype and Mechanosensitive Properties of Different Tendon Cell Populations

Advanced Science, EarlyView.
Tendon interfascicular and fascicular matrix cells are isolated and cultured, revealing distinct phenotypes and mechanosensitive responses. Interfascicular matrix cells exhibit marked stiffness‐dependent phenotypic plasticity, whereas fascicular matrix cells remain comparatively stable.
S. E. Grossemy, D. E. Zamboulis, N. S. Khatib, M. R. Fazal, C. C. Gains, A. Giannopoulos, T. Hopkins, C. Bevan, Y. Aggarwal, M. M. Knight, H. R. C. Screen   +10 more
wiley   +1 more source

New insights into FAK phosphorylation based on a FAT domain-defective mutation. [PDF]

PLoS ONE, 2014
Mounting evidence suggests that the FAK N-terminal (FERM) domain controls FAK phosphorylation and function; however, little is known regarding the role of the C terminal (FAT) domain in FAK regulation. We identified a patient-derived FAK mutant, in which
Xuqian Fang, Xiangfan Liu, Ling Yao, Changqiang Chen, Jiafei Lin, Peihua Ni, Xinmin Zheng, Qishi Fan   +7 more
doaj   +1 more source

High expression of phosphorylated focal adhesion kinase predicts a poor prognosis in human colorectal cancer

Frontiers in Pharmacology, 2022
Background: Phosphorylated Focal adhesion kinase (FAK) has been reported to be intimately involved in various malignant tumors. The effect of p-FAK on colorectal cancer (CRC) is still disputable.
Guanyu Yu, Mengnan Xu, Leqi Zhou, Kuo Zheng, Xiaoming Zhu, Jinke Sui, Cheng Xin, Wenjun Chang, Wei Zhang, Fuao Cao   +9 more
doaj   +1 more source

PIEZO1 Channel is Involved in Electric Field Guided Cell Migration

Shengwu huaxue yu shengwu wuli jinzhan
ObjectiveDisruption of epithelial layer may instantaneously induce the generation of endogenous electric fields, which was proved to play an important role in guiding the cell migration and promoting wound healing.
ZHANG Gui-Cheng, GONG Peng, WANG Yi-Fan, ZHAO San-Jun   +3 more
doaj   +1 more source

The FAK-Del33 mutation reduces Src independence.

, 2014
(A) MDA-MB-468 cells were transfected with FAK-WT, FAK-Del33, FAK-WT/Δ375, and FAK-Del33/Δ375. The cells were serum starved overnight and replated onto FN-coated plates in the presence of the Src inhibitor PP2 or the control compound PP3.
Xiangfan Liu (294313), Peihua Ni (294310), Qishi Fan (294315), Ling Yao (16961), Changqiang Chen (294311), Xuqian Fang (630321), Jiafei Lin (630322), Xinmin Zheng (401187)   +7 more
core   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source