Results 41 to 50 of about 52,035 (209)

FAK auto-phosphorylation site tyrosine 397 is required for development but dispensable for normal skin homeostasis.

PLoS ONE, 2018
Focal adhesion kinase (FAK) is an intensely studied non-receptor tyrosine kinase with roles in cancer and other common human diseases. Despite the large interest in FAK, the in vivo contribution of FAK auto-phosphorylation site tyrosine (Y) 397 to FAK ...
Joel B Heim, Cera A McDonald, Saranya P Wyles, Sindhuja Sominidi-Damodaran, Edwin J Squirewell, Ming Li, Catherine Motsonelidze, Ralph T Böttcher, Jan van Deursen, Alexander Meves   +9 more
doaj   +1 more source

FAK Regulates VEGFR2 Expression and Promotes Angiogenesis in Triple-Negative Breast Cancer

Biomedicines, 2021
Triple-negative breast cancer (TNBC) remains a significant clinical challenge because of its high vascularity and metastatic and recurrent rates.
Jun-Ping Shiau, Cheng-Che Wu, Shu-Jyuan Chang, Mei-Ren Pan, Wangta Liu, Fu Ou-Yang, Fang-Ming Chen, Ming-Feng Hou, Shen-Liang Shih, Chi-Wen Luo   +9 more
doaj   +1 more source

Phosphorylation status of FAK and FAK substrates in FAK^-/- cells re-expressing wild-type FAK and FAK^I936/I998.

, 2014
(A) Graphs show decreased FAK phosphorylation at Tyr397, Tyr576 and Tyr925 in FAKI936/I998 cells compared to wild-type FAK cells ...
Ken Takeda (441984), Thérèse B. Deramaudt (538784), Philippe Rondé (538786), Fanny Noulet (538785), Sophie Martin (254058), Denis Dujardin (25529), Romain Vauchelles (360387)   +6 more
core   +1 more source

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

Advanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren, Alex Wu, Lucas Ramirez, Yaqing Huang, Connor Amelung, Sophia Saxonhouse, Sharon Gerecht   +6 more
wiley   +1 more source

FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing. [PDF]

PLoS ONE, 2011
Following damage to the intestinal epithelium, restoration of epithelial barrier integrity is triggered by a robust proliferative response. In other tissues, focal adhesion kinase (FAK) regulates many of the cellular processes that are critical for ...
Katherine A Owen, Michelle Y Abshire, Robert W Tilghman, James E Casanova, Amy H Bouton   +4 more
doaj   +1 more source

Effect of focal adhesion kinase inhibition on osteoblastic cells grown on titanium with different topographies [PDF]

Journal of Applied Oral Science, 2020
Objective The present study aimed to investigate the participation of focal adhesion kinases (FAK) in interactions between osteoblastic cells and titanium (Ti) surfaces with three different topographies, namely, untreated (US), microstructured (MS), and
Helena Bacha LOPES, Alann Thaffarell Portilho SOUZA, Gileade Pereira FREITAS, Carlos Nelson ELIAS, Adalberto Luiz ROSA, Marcio Mateus BELOTI   +5 more
doaj   +1 more source

p130Cas distribution in FAK^-/-, wild-type FAK and FAK^I936/I998 cells.

, 2014
(A) Confocal images of fixed FAK-/-cells expressing or not (NT, non-transfected cells) wild-type or mutant FAK-GFP (left panel) and immunostained for p130Cas (right panel).
Ken Takeda (441984), Thérèse B. Deramaudt (538784), Philippe Rondé (538786), Fanny Noulet (538785), Sophie Martin (254058), Denis Dujardin (25529), Romain Vauchelles (360387)   +6 more
core   +1 more source

Robotics in Ionizing Radiation Environments: Vulnerabilities, Hardening, and Future Directions

Advanced Robotics Research, EarlyView.
Radiation exposure causes cumulative degradation in robotic sensors, actuators, and electronic logic, often leading to undetected failures. This study maps component vulnerabilities, evaluates hardening and shielding strategies, and identifies testing gaps that must be addressed to enable next‐generation radiation‐tolerant robotic systems.
Francis A. K. Djirackor, Josephine T. Djirackor, Amanuel Abrdo Tereda, Sun Yi, Younho Seong   +4 more
wiley   +1 more source

Quantification of focal adhesions in FAK, FAK^I936/I998 and FAK^-/- cells.

, 2014
(A) Confocal images from fixed FAK-/- cells expressing or not wild-type or mutant FAK-GFP and immunostained for paxillin. Evaluation of paxillin-containing FAs reveals no significant decrease in the number of FAs in FAKI936/I998 cells as compared to FAK-/
Ken Takeda (441984), Thérèse B. Deramaudt (538784), Philippe Rondé (538786), Fanny Noulet (538785), Sophie Martin (254058), Denis Dujardin (25529), Romain Vauchelles (360387)   +6 more
core   +1 more source

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source