Obesity promotes urinary tract infection by disrupting bladder focal adhesion kinase signaling [PDF]
iScienceSummary: Obesity is a significant public health concern associated with numerous health risks. Infections are a major complication of obesity, but the mechanisms driving increased infection risk remain unclear. Using a diet-induced obesity mouse model in
Laura Schwartz +10 more
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Mechanism of Focal Adhesion Kinase Mechanosensing.
PLoS Computational Biology, 2015 Mechanosensing at focal adhesions regulates vital cellular processes. Here, we present results from molecular dynamics (MD) and mechano-biochemical network simulations that suggest a direct role of Focal Adhesion Kinase (FAK) as a mechano-sensor. Tensile
Jing Zhou +5 more
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Phospho-regulated tethering of focal adhesion kinase to vinculin links force transduction to focal adhesion signaling [PDF]
Cell Communication and SignalingFocal Adhesion Kinase (FAK) is a key signaling molecule in focal adhesions (FAs) orchestrating the formation, maturation and turnover of the FA complex.
Karen Diaz-Palacios +6 more
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The role of focal adhesion kinase in bladder cancer: translation from in vitro to ex vivo human urothelial carcinomas [PDF]
Radiology and OncologyFocal adhesion kinase (FAK), a cytoplasmic tyrosine kinase, plays a crucial role in focal adhesion turnover by interfacing between the extracellular space, transmembrane integrins, and actin filaments.
Markovic Gaja +10 more
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Activation of Rho-kinase and focal adhesion kinase regulates the organization of stress fibers and focal adhesions in the central part of fibroblasts [PDF]
PeerJ, 2017 Specific regulation and activation of focal adhesion kinase (FAK) are thought to be important for focal adhesion formation, and activation of Rho-kinase has been suggested to play a role in determining the effects of FAK on the formation of stress fibers
Kazuo Katoh
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Cas phosphorylation regulates focal adhesion assembly
eLife, 2023 Integrin-mediated cell attachment rapidly induces tyrosine kinase signaling. Despite years of research, the role of this signaling in integrin activation and focal adhesion assembly is unclear.
Saurav Kumar +4 more
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PIPKIγ regulates focal adhesion dynamics and colon cancer cell invasion. [PDF]
PLoS ONE, 2011 Focal adhesion assembly and disassembly are essential for cell migration and cancer invasion, but the detailed molecular mechanisms regulating these processes remain to be elucidated. Phosphatidylinositol phosphate kinase type Iγ (PIPKIγ) binds talin and
Zhaofei Wu +5 more
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Focal Adhesion Kinases in Adhesion Structures and Disease [PDF]
Journal of Signal Transduction, 2012 Cell adhesion to the extracellular matrix (ECM) is essential for cell migration, proliferation, and embryonic development. Cells can contact the ECM through a wide range of matrix contact structures such as focal adhesions, podosomes, and invadopodia.
Eleniste, Pierre P, Bruzzaniti, Angela
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Cell Death and Disease, 2023 Numerous studies have investigated the various cellular responses against genotoxic stress, including those mediated by focal adhesions. We here identified a novel type of focal adhesion remodelling that occurs under genotoxic stress conditions, which ...
Masatsune Tsujioka +8 more
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Pulmonary Circulation, 2021 Increases in lung vascular permeability is a cardinal feature of inflammatory disease and represents an imbalance in vascular contractile forces and barrier‐restorative forces, with both forces highly dependent upon the actin cytoskeleton.
Joseph B. Mascarenhas +10 more
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