Results 1 to 10 of about 1,221,131 (252)

Obesity promotes urinary tract infection by disrupting bladder focal adhesion kinase signaling [PDF]

iScience
Summary: Obesity is a significant public health concern associated with numerous health risks. Infections are a major complication of obesity, but the mechanisms driving increased infection risk remain unclear. Using a diet-induced obesity mouse model in
Laura Schwartz, Kristin Salamon, Aaron Simoni, Israel Cotzomi-Ortega, Yuriko Sanchez-Zamora, Sarah Linn-Peirano, Preeti John, Juan de Dios Ruiz-Rosado, Ashley R. Jackson, Xin Wang, John David Spencer   +10 more
doaj   +2 more sources

Phospho-regulated tethering of focal adhesion kinase to vinculin links force transduction to focal adhesion signaling [PDF]

Cell Communication and Signaling
Focal Adhesion Kinase (FAK) is a key signaling molecule in focal adhesions (FAs) orchestrating the formation, maturation and turnover of the FA complex.
Karen Diaz-Palacios, Pilar López Navajas, Bárbara Rodrigo Martín, Ruth Matesanz, Juan R. Luque-Ortega, Asier Echarri, Daniel Lietha   +6 more
doaj   +3 more sources

The role of focal adhesion kinase in bladder cancer: translation from in vitro to ex vivo human urothelial carcinomas [PDF]

Radiology and Oncology
Focal adhesion kinase (FAK), a cytoplasmic tyrosine kinase, plays a crucial role in focal adhesion turnover by interfacing between the extracellular space, transmembrane integrins, and actin filaments.
Markovic Gaja, Resnik Natasa, Janev Aleksandar, Zupancic Dasa, Grubelnik Gasper, Debeljak Marusa, Cemazar Maja, Jesenko Tanja, Omerzel Masa, Smrkolj Tomaz, Kreft Mateja Erdani   +10 more
doaj   +2 more sources

Activation of Rho-kinase and focal adhesion kinase regulates the organization of stress fibers and focal adhesions in the central part of fibroblasts [PDF]

PeerJ, 2017
Specific regulation and activation of focal adhesion kinase (FAK) are thought to be important for focal adhesion formation, and activation of Rho-kinase has been suggested to play a role in determining the effects of FAK on the formation of stress fibers
Kazuo Katoh
doaj   +2 more sources

Cas phosphorylation regulates focal adhesion assembly

eLife, 2023
Integrin-mediated cell attachment rapidly induces tyrosine kinase signaling. Despite years of research, the role of this signaling in integrin activation and focal adhesion assembly is unclear.
Saurav Kumar, Amanda Stainer, Julien Dubrulle, Christopher Simpkins, Jonathan A Cooper   +4 more
doaj   +1 more source

PIPKIγ regulates focal adhesion dynamics and colon cancer cell invasion. [PDF]

PLoS ONE, 2011
Focal adhesion assembly and disassembly are essential for cell migration and cancer invasion, but the detailed molecular mechanisms regulating these processes remain to be elucidated. Phosphatidylinositol phosphate kinase type Iγ (PIPKIγ) binds talin and
Zhaofei Wu, Xiang Li, Manjula Sunkara, Heather Spearman, Andrew J Morris, Cai Huang   +5 more
doaj   +1 more source

Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer progression

Cell Death and Disease, 2023
Numerous studies have investigated the various cellular responses against genotoxic stress, including those mediated by focal adhesions. We here identified a novel type of focal adhesion remodelling that occurs under genotoxic stress conditions, which ...
Masatsune Tsujioka, Keisuke Miyazawa, Masaki Ohmuraya, Yoichi Nibe, Tetsuya Shirokawa, Haruko Hayasaka, Tsunekazu Mizushima, Takeshi Fukuma, Shigeomi Shimizu   +8 more
doaj   +1 more source

EVL is a novel focal adhesion protein involved in the regulation of cytoskeletal dynamics and vascular permeability

Pulmonary Circulation, 2021
Increases in lung vascular permeability is a cardinal feature of inflammatory disease and represents an imbalance in vascular contractile forces and barrier‐restorative forces, with both forces highly dependent upon the actin cytoskeleton.
Joseph B. Mascarenhas, Amir A. Gaber, Tania M. Larrinaga, Rachel Mayfield, Stefanie Novak, Sara M. Camp, Carol Gregorio, Jeffrey R. Jacobson, Anne E. Cress, Steven M. Dudek, Joe G.N. Garcia   +10 more
doaj   +1 more source

Focal Adhesion Kinase Binds to the HPV E2 Protein to Regulate Initial Replication after Infection

Pathogens, 2023
Human papillomaviruses are small DNA tumor viruses that infect cutaneous and mucosal epithelia. The viral lifecycle is linked to the differentiation status of the epithelium.
Leny Jose, Jessica Gonzalez, Emma Kessinger, Elliot J. Androphy, Marsha DeSmet   +4 more
doaj   +1 more source

Inhibition of focal adhesion kinase overcomes resistance of mantle cell lymphoma to ibrutinib in the bone marrow microenvironment

Haematologica, 2018
Mantle cell lymphoma and other lymphoma subtypes often spread to the bone marrow, and stromal interactions mediated by focal adhesion kinase frequently enhance survival and drug resistance of the lymphoma cells. To study the role of focal adhesion kinase
Martina Rudelius, Mathias Tillmann Rosenfeldt, Ellen Leich, Hilka Rauert-Wunderlich, Antonio Giovanni Solimando, Andreas Beilhack, German Ott, Andreas Rosenwald   +7 more
doaj   +1 more source