Results 41 to 50 of about 156,176 (352)
Cell Transplantation, 2013 Emerging evidence suggests that cell therapy with mesenchymal stem cells (MSCs) has beneficial effects on the injured heart. However, the decreased survival and/or adhesion of MSCs under ischemic conditions limits the application of cell transplantation ...
Byeong-Wook Song +14 more
doaj +1 more source
Abnormal Endothelial Gene Expression Associated With Early Coronary Atherosclerosis
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background We examined feasibility of a unique approach towards gaining insight into heritable risk for early atherosclerosis: surveying gene expression by endothelial cells from living subjects. Methods and Results Subjects aged
Robert P. Hebbel +9 more
doaj +1 more source
Novel Phosphotidylinositol 4,5-Bisphosphate Binding Sites on Focal Adhesion Kinase. [PDF]
PLoS ONE, 2015 Focal adhesion kinase (FAK) is a protein tyrosine kinase that is ubiquitously expressed, recruited to focal adhesions, and engages in a variety of cellular signaling pathways.
Jun Feng, Blake Mertz
doaj +1 more source
CaMKK2 Regulates Mechanosensitive Assembly of Contractile Actin Stress Fibers
Cell Reports, 2018 Summary: Stress fibers are contractile actomyosin bundles that guide cell adhesion, migration, and morphogenesis. Their assembly and alignment are under precise mechanosensitive control.
Sari Tojkander +2 more
doaj +1 more source
Designing stem cell niches for differentiation and self-renewal [PDF]
, 2018 Mesenchymal stem cells, characterized by their ability to differentiate into skeletal tissues and self-renew, hold great promise for both regenerative medicine and novel therapeutic discovery. However, their regenerative capacity is retained only when in
Dalby, Matthew J. +2 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
AMBRA1 and FAK1: crosstalking for improved targeted therapy in melanoma
Molecular & Cellular Oncology, 2021 Through genetically engineered mouse models of melanoma, we identified Autophagy/beclin 1 regulator 1 (Ambra1) as novel tumor-suppressor in melanoma. In these settings, loss of Ambra1 associated with the hyperactivation of focal adhesion kinase 1 (Fak1 ...
Luca Di Leo, Daniela De Zio
doaj +1 more source
Caldesmon regulates actin dynamics to influence cranial neural crest migration in Xenopus [PDF]
, 2011 Caldesmon (CaD) is an important actin modulator that associates with actin filaments to regulate cell morphology and motility. Although extensively studied in cultured cells, there is little functional information regarding the role of CaD in migrating ...
Bronner-Fraser, Marianne +2 more
core +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
ADAM23 in Cardiomyocyte Inhibits Cardiac Hypertrophy by Targeting FAK‐AKT Signaling
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 Background Cardiac hypertrophy has been recognized as an important independent risk factor for the development of heart failure and increases the risk of cardiac morbidity and mortality.
Mei Xiang +14 more
doaj +1 more source