Results 21 to 30 of about 84,022 (261)
Endothelial Cell mTOR Complex-2 Regulates Sprouting Angiogenesis. [PDF]
PLoS ONE, 2015 Tumor neovascularization is targeted by inhibition of vascular endothelial growth factor (VEGF) or the receptor to prevent tumor growth, but drug resistance to angiogenesis inhibition limits clinical efficacy.
Maikel A Farhan +4 more
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Focal adhesion kinase as an immunotherapeutic target [PDF]
Cancer Immunology, Immunotherapy, 2008 Focal adhesion kinase (FAK) is a ubiquitously expressed non-receptor tyrosine kinase involved in cancer progression and metastasis that is found overexpressed in a large number of tumors such as breast, colon, prostate, melanoma, head and neck, lung and ovary.
Hiroya, Kobayashi +9 more
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Protein Kinase A is a Functional Component of Focal Adhesions
Journal of Biological Chemistry, 2023 ABSTRACT Focal adhesions (FAs) form the junction between extracellular matrix (ECM)-bound integrins and the actin cytoskeleton and also transmit signals that regulate cell adhesion, cytoskeletal dynamics, and cell migration. While many of these signals are rooted in reversible tyrosine phosphorylation, phosphorylation of FA proteins on ...
Mingu Kang +7 more
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FAK family kinases: The Yin and Yang of cancer cell invasiveness
Molecular & Cellular Oncology, 2018 Proline-rich tyrosine kinase 2 (PYK2, also known as Pyk2) and its closely related focal adhesion kinase (FAK) modulate cancer cell invasion by coordinating the balance between focal adhesion-mediated migration and invadopodia-dependent extracellular ...
Alessandro Genna, Hava Gil-Henn
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FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions
Biomolecules, 2020 Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase with key roles in the regulation of cell adhesion migration, proliferation and survival. In cancer FAK is a major driver of invasion and metastasis and its upregulation is associated with poor
Paula Tapial Martínez +2 more
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PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility
Cells, 2020 Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associated with poor prognosis of cancer patients.
Hsin-Wei Jen +3 more
doaj +1 more source
Focal adhesion kinase inhibitors, a heavy punch to cancer
Discover Oncology, 2021 Kinases are the ideal druggable targets for diseases and especially were highlighted on cancer therapy. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and its aberrant signaling extensively implicates in the progression of most cancer ...
Yueling Wu +7 more
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Requirement of focal adhesion kinase in branching tubulogenesis
Journal of Biomedical Science, 2009 We previously demonstrated that α3β1 integrins are essential to hepatocyte growth factor (HGF)-independent branching tubulogenesis in Mardin-Darby Canine Kidney (MDCK) cells.
Wei Wei-Chun +2 more
doaj +1 more source
Activation of pyk2/Related Focal Adhesion Tyrosine Kinase and Focal Adhesion Kinase in Cardiac Remodeling [PDF]
Journal of Biological Chemistry, 2002 Cellular remodeling during progression of dilation involves focal adhesion contact reorganization. However, the signaling mechanisms and structural consequences leading to impaired cardiomyocyte adhesion are poorly defined. These events were studied in tropomodulin-overexpressing transgenic mice that develop dilated cardiomyopathy associated with ...
Meléndez Rojel, Jaime Gumercindo +6 more
openaire +3 more sources
Cell Transplantation, 2013 Emerging evidence suggests that cell therapy with mesenchymal stem cells (MSCs) has beneficial effects on the injured heart. However, the decreased survival and/or adhesion of MSCs under ischemic conditions limits the application of cell transplantation ...
Byeong-Wook Song +14 more
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