Results 21 to 30 of about 1,221,131 (252)

FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions

Biomolecules, 2020
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase with key roles in the regulation of cell adhesion migration, proliferation and survival. In cancer FAK is a major driver of invasion and metastasis and its upregulation is associated with poor
Paula Tapial Martínez, Pilar López Navajas, Daniel Lietha   +2 more
doaj   +1 more source

PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility

Cells, 2020
Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associated with poor prognosis of cancer patients.
Hsin-Wei Jen, De-Leung Gu, Yaw-Dong Lang, Yuh-Shan Jou   +3 more
doaj   +1 more source

Focal adhesion kinase inhibitors, a heavy punch to cancer

Discover Oncology, 2021
Kinases are the ideal druggable targets for diseases and especially were highlighted on cancer therapy. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and its aberrant signaling extensively implicates in the progression of most cancer ...
Yueling Wu, Ning Li, Chengfeng Ye, Xingmei Jiang, Hui Luo, Baoyuan Zhang, Ying Zhang, Qingyu Zhang   +7 more
doaj   +1 more source

Requirement of focal adhesion kinase in branching tubulogenesis

Journal of Biomedical Science, 2009
We previously demonstrated that α3β1 integrins are essential to hepatocyte growth factor (HGF)-independent branching tubulogenesis in Mardin-Darby Canine Kidney (MDCK) cells.
Wei Wei-Chun, Kopec Anna K, Tang Ming-Jer   +2 more
doaj   +1 more source

A role for Syk-kinase in the control of the binding cycle of the β2 integrins (CD11/CD18) in human polymorphonuclear neutrophils [PDF]

, 2003
A fine control of β2 integrin (CD11/CD18)-mediated firm adhesion of human neutrophils to the endothelial cell monolayer is required to allow ordered emigration.
Walzog, Barbara, Prange, Peggy, Willeke, Thomas, Zahler, Stefan, Schymeinsky, Jürgen   +4 more
core   +1 more source

Overexpressed Focal Adhesion Kinase Predicts a Higher Incidence of Extrahepatic Metastasis and Worse Survival in Hepatocellular Carcinoma

, 2011
Focal adhesion kinase plays a critical role in cancer progression, invasion, and metastasis. Although focal adhesion kinase overexpression indicates poor prognoses for hepatocellular carcinoma, its role in hepatocellular carcinoma metastasis has not been
詹以吉;柯博升;許駿;王約翰;劉俊揚, JAN, YEE-JEE;KO, BO-SHENG;HSU, CHIUN;WANG, JOHN;LIOU, JUN-YANG   +1 more
core   +1 more source

Modulation of cell-matrix adhesions to affect mechanotransduction [PDF]

, 2010
In cultured fibroblasts three types of cell-matrix adhesion with specific cellular localization and protein composition can be distinguished: focal complexes, focal adhesions and fibrillar adhesions.
Lutz, Roman
core   +1 more source

Protein Kinase C Activation Stimulates Mesenchymal Stem Cell Adhesion through Activation of Focal Adhesion Kinase

Cell Transplantation, 2013
Emerging evidence suggests that cell therapy with mesenchymal stem cells (MSCs) has beneficial effects on the injured heart. However, the decreased survival and/or adhesion of MSCs under ischemic conditions limits the application of cell transplantation ...
Byeong-Wook Song, Woochul Chang, Bum-Kee Hong, Il-Kwon Kim, Min-Ji Cha, Soyeon Lim, Eun Ju Choi, Onju Ham, Se-Yeon Lee, Chang Youn Lee, Jun-Hee Park, Eunmi Choi, Heesang Song, Yangsoo Jang, Ki-Chul Hwang Ph.D.   +14 more
doaj   +1 more source

Focal adhesion kinase: from biological functions to therapeutic strategies

Experimental Hematology & Oncology, 2023
Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital participant in primary cellular functions, such as proliferation, survival, migration, and invasion. In addition, FAK regulates cancer stem cell activities and contributes
Ximin Tan, Yuheng Yan, Bin Song, Shuangli Zhu, Qi Mei, Kongming Wu   +5 more
doaj   +1 more source

Mechanotransduction in striated muscle via focal adhesion kinase [PDF]

, 2007
Contractile tissues demonstrate a pronounced capacity to remodel their composition in response to mechanical challenges. Descriptive evidence suggests the upstream involvement of the phosphotransfer enzyme FAK (focal adhesion kinase) in the molecular ...
M Flück, Desplanches, D, Durieux, AC, Flück, M, Flueck, M., D Freyssenet, Freyssenet, D., Freyssenet, D, A C Durieux, Durieux, A. C., D Desplanches, Freyssenet, O, Durieux, A C, Desplanches, D.   +13 more
core   +1 more source