Results 11 to 20 of about 1,221,131 (252)

Flotillins Regulate Focal Adhesions by Interacting with α-Actinin and by Influencing the Activation of Focal Adhesion Kinase

Cells, 2018
Cell–matrix adhesion and cell migration are physiologically important processes that also play a major role in cancer spreading. In cultured cells, matrix adhesion depends on integrin-containing contacts such as focal adhesions. Flotillin-1 and flotillin-
Antje Banning, Tanja Babuke, Nina Kurrle, Melanie Meister, Mika O. Ruonala, Ritva Tikkanen   +5 more
doaj   +2 more sources

Mechanism of Focal Adhesion Kinase Mechanosensing.

PLoS Computational Biology, 2015
Mechanosensing at focal adhesions regulates vital cellular processes. Here, we present results from molecular dynamics (MD) and mechano-biochemical network simulations that suggest a direct role of Focal Adhesion Kinase (FAK) as a mechano-sensor. Tensile
Jing Zhou, Camilo Aponte-Santamaría, Sebastian Sturm, Jakob Tómas Bullerjahn, Agnieszka Bronowska, Frauke Gräter   +5 more
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Modelling stromal FAK regulation of tumour growth, angiogenesis and progression [PDF]

, 2012
PhDThe growth of tumours within a whole organism depends on the tumour microenvironment. This involves both resident stromal cells, such as endothelial cells and fibroblasts, and also bone marrow derived stromal cells.
Batista, Silvia
core   +4 more sources

FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells [PDF]

, 2011
Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that is elevated in a variety of human cancers. While FAK is implicated in many cellular processes that are perturbed in cancer, including proliferation, actin and adhesion dynamics ...
Moran-Jones Kim, Moran-Jones, K., Graham Kathryn, Brunton Valerie G., Margaret C Frame, Owen J. Sansom, Frame, Margaret C., Moran-jones, Kim, Frame, M.C., Sansom, Owen J., Owen J Sansom, Brunton, V.G., Valerie G Brunton, Frame Margaret C., Valerie G. Brunton, Margaret C. Frame, Graham, K., Brunton, Valerie G., Kathryn Graham, Graham, Kathryn, Sansom Owen J., Sansom, O.J., Kim Moran-Jones   +22 more
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αV-Integrins Are Required for Mechanotransduction in MDCK Epithelial Cells [PDF]

, 2013
The properties of epithelial cells within tissues are regulated by their immediate microenvironment, which consists of neighboring cells and the extracellular matrix (ECM).
Muller, Daniel J, Myllymäki, Satu M., Jens Friedrichs, Aki Manninen (221960), Matlin, Karl S., Daniel J. Muller (2509858), Manninen, Aki, Myllymäki Satu M., Manninen Aki, Jose V Moyano, Strohmeyer, Nico; id_orcid, Teräväinen, Terhi P, Muller Daniel J., Terhi P. Teräväinen (447383), Jens Friedrichs (447385), Muller, Daniel J., Satu M Myllymäki, Engler, Adam J., Friedrichs Jens, Chuanyue Wu (196653), Satu M. Myllymäki (447384), Strohmeyer, Nico, Nico Strohmeyer (447386), Karl S. Matlin (447388), Moyano, Jose V, Teräväinen, Terhi P., Terhi P Teräväinen, Karl S Matlin, Chuanyue Wu, Wu, Chuanyue, Moyano, Jose V., Strohmeyer Nico, Myllymäki, Satu M, Aki Manninen, Daniel J Muller, Jose V. Moyano (447387), Matlin Karl S., Wu Chuanyue, Moyano Jose V., Nico Strohmeyer, Matlin, Karl S, Friedrichs, Jens, Teräväinen Terhi P.   +42 more
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Epidermal Growth Factor Receptor substrate 8 (Eps8) controls Src/FAK-dependent phenotypes in squamous carcinoma cells [PDF]

, 2014
Eps8 is an actin regulatory scaffold protein increased in Squamous Cell Carcinoma (SCC) cells. It forms a complex with both Focal Adhesion Kinase (FAK) and c-Src in SCC cells derived from the DMBA/TPA model of skin carcinogenesis.
Schoenherr, Christina, Baillie, George S., Frame, Margaret, Heath, John K., Proby, Charlotte, Frame, Margaret C., Cunningham, Debbie L, Findlay, Jane E, Cunningham, Debbie L., Findlay, Jane E., Baillie, George S, Heath, John K, Serrels, Bryan, Frame, Margaret C   +13 more
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Costamere remodeling with muscle loading and unloading in healthy young men [PDF]

, 2013
Costameres are mechano-sensory sites of focal adhesion in the sarcolemma that provide a structural anchor for myofibrils. Their turnover is regulated by integrin-associated focal adhesion kinase (FAK).
Erskine, Robert M., Seynnes, Olivier R., Simunic, B, Narici, MV, Flück M., Pisot, R, Flück, M., Rittweger J., Rittweger, Joern, Flueck, M, Narici M. V., Narici, Marco, Narici, Marco V., Flück, Martin, Seynnes O. R., Erskine, Robert, Li R., Rittweger, Jörn, Rittweger, J, Pisot, Rado, Seynnes, Olivier R, Seynnes, OR, Pišot R., Seynnes, Olivier, Li, Ruowei, Erskine, Robert M, Narici, Marco V, Erskine, RM, Šimunič B., Narici, Marco Vincenzo, Simunic, Bostjan, Erskine R. M., Li, R   +32 more
core   +1 more source

ADAM15 modulates outside-in signalling in chondrocyte–matrix interactions [PDF]

, 2008
ADAM15 belongs to a family of transmembrane multi-domain proteins implicated in proteolysis, cell–cell and cell–matrix interactions in various disease conditions.
Böhm, Beate B., Schirner, Andrea, Harald Burkhardt, Burkhardt, Harald, Andrea Schirner, Beate B. Böhm   +5 more
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Endothelial Cell mTOR Complex-2 Regulates Sprouting Angiogenesis. [PDF]

PLoS ONE, 2015
Tumor neovascularization is targeted by inhibition of vascular endothelial growth factor (VEGF) or the receptor to prevent tumor growth, but drug resistance to angiogenesis inhibition limits clinical efficacy.
Maikel A Farhan, Katia Carmine-Simmen, John D Lewis, Ronald B Moore, Allan G Murray   +4 more
doaj   +1 more source

FAK family kinases: The Yin and Yang of cancer cell invasiveness

Molecular & Cellular Oncology, 2018
Proline-rich tyrosine kinase 2 (PYK2, also known as Pyk2) and its closely related focal adhesion kinase (FAK) modulate cancer cell invasion by coordinating the balance between focal adhesion-mediated migration and invadopodia-dependent extracellular ...
Alessandro Genna, Hava Gil-Henn
doaj   +1 more source