Results 11 to 20 of about 84,022 (261)

Focal Adhesion Kinase Binds to the HPV E2 Protein to Regulate Initial Replication after Infection

Pathogens, 2023
Human papillomaviruses are small DNA tumor viruses that infect cutaneous and mucosal epithelia. The viral lifecycle is linked to the differentiation status of the epithelium.
Leny Jose, Jessica Gonzalez, Emma Kessinger, Elliot J. Androphy, Marsha DeSmet   +4 more
doaj   +1 more source

In Vitro Phosphorylation of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase by Src Kinase [PDF]

Biochemistry, 2012
Focal adhesion kinase (FAK), a key regulator of cell adhesion and migration, is overexpressed in many types of cancer. The C-terminal focal adhesion targeting (FAT) domain of FAK is necessary for proper localization of FAK to focal adhesions and subsequent activation.
Jennifer, Cable, Kirk, Prutzman, Harsha P, Gunawardena, Michael D, Schaller, Xian, Chen, Sharon L, Campbell   +5 more
openaire   +2 more sources

Focal Adhesion Kinase: a regulator of focal adhesion dynamics and cell movement [PDF]

Oncogene, 2000
Engagement of integrin receptors with extracellular ligands gives rise to the formation of complex multiprotein structures that link the ECM to the cytoplasmic actin cytoskeleton. These adhesive complexes are dynamic, often heterogeneous structures, varying in size and organization.
J T, Parsons, K H, Martin, J K, Slack, J M, Taylor, S A, Weed   +4 more
openaire   +2 more sources

Inhibition of focal adhesion kinase overcomes resistance of mantle cell lymphoma to ibrutinib in the bone marrow microenvironment

Haematologica, 2018
Mantle cell lymphoma and other lymphoma subtypes often spread to the bone marrow, and stromal interactions mediated by focal adhesion kinase frequently enhance survival and drug resistance of the lymphoma cells. To study the role of focal adhesion kinase
Martina Rudelius, Mathias Tillmann Rosenfeldt, Ellen Leich, Hilka Rauert-Wunderlich, Antonio Giovanni Solimando, Andreas Beilhack, German Ott, Andreas Rosenwald   +7 more
doaj   +1 more source

Focal adhesion kinase and cancer.

Histology and histopathology, 2009
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that resides at the sites of integrin clustering, known as focal adhesions. The FAK protein has a molecular mass of 125kDa and is encoded by the FAK gene located on human chromosome 8q24.
Golubovskaya1, Vita M., Kweh, Frederick A., Cance, William G.   +2 more
openaire   +3 more sources

Focal adhesion kinase and tumour angiogenesis [PDF]

The Journal of Pathology, 2011
AbstractAngiogenesis, the formation of new blood vessels from pre‐existing ones, is essential for tumour development. It is initiated and regulated by growth factors via their surface receptors, which activate several intracellular signalling pathways in endothelial cells. Cell adhesion molecules, such as integrins, also regulate angiogenesis.
Tanguy, Lechertier, Kairbaan, Hodivala-Dilke   +1 more
openaire   +2 more sources

Targeting Focal Adhesion Kinase in Neuroblastoma [PDF]

Anti-Cancer Agents in Medicinal Chemistry, 2010
Neuroblastoma is the most common extracranial solid tumor encountered in children, and continues to carry a dismal prognosis. Focal adhesion kinase (FAK) has been shown to be upregulated in a number of human tumors and is related to tumor virulence and patient prognosis.
Lauren, Gillory, Elizabeth A, Beierle
openaire   +2 more sources

Focal adhesion kinase regulation of neovascularization [PDF]

Microvascular Research, 2012
In this review, we discuss the role of focal adhesion kinase (FAK), an intracellular tyrosine kinase, in endothelial cells in relation to neovascularization. Genetic and in vitro studies have identified critical factors, receptor systems, and their intracellular signaling components that regulate the neovasculogenic phenotypes of endothelial cells ...
Kishore K, Wary, Erin E, Kohler, Ishita, Chatterjee   +2 more
openaire   +2 more sources

Focal Adhesion Kinase Stabilizes the Cytoskeleton [PDF]

Biophysical Journal, 2011
Focal adhesion kinase (FAK) is a central focal adhesion protein that promotes focal adhesion turnover, but the role of FAK for cell mechanical stability is unknown. We measured the mechanical properties of wild-type (FAKwt), FAK-deficient (FAK-/-), FAK-silenced (siFAK), and siControl mouse embryonic fibroblasts by magnetic tweezer, atomic force ...
Fabry, Ben, Klemm, Anna H., Kienle, Sandra, Schäffer, Tilman E., Goldmann, Wolfgang H.   +4 more
openaire   +2 more sources

Flotillins Regulate Focal Adhesions by Interacting with α-Actinin and by Influencing the Activation of Focal Adhesion Kinase

Cells, 2018
Cell–matrix adhesion and cell migration are physiologically important processes that also play a major role in cancer spreading. In cultured cells, matrix adhesion depends on integrin-containing contacts such as focal adhesions. Flotillin-1 and flotillin-
Antje Banning, Tanja Babuke, Nina Kurrle, Melanie Meister, Mika O. Ruonala, Ritva Tikkanen   +5 more
doaj   +1 more source