Results 31 to 40 of about 84,059 (261)

Activation of pyk2/Related Focal Adhesion Tyrosine Kinase and Focal Adhesion Kinase in Cardiac Remodeling [PDF]

Journal of Biological Chemistry, 2002
Cellular remodeling during progression of dilation involves focal adhesion contact reorganization. However, the signaling mechanisms and structural consequences leading to impaired cardiomyocyte adhesion are poorly defined. These events were studied in tropomodulin-overexpressing transgenic mice that develop dilated cardiomyopathy associated with ...
Meléndez Rojel, Jaime Gumercindo, Welch, S., Schaefer, E., Moravec, C.S., Avraham, S., Avraham, H., Sussman, M.A.   +6 more
openaire   +3 more sources

CaMKK2 Regulates Mechanosensitive Assembly of Contractile Actin Stress Fibers

Cell Reports, 2018
Summary: Stress fibers are contractile actomyosin bundles that guide cell adhesion, migration, and morphogenesis. Their assembly and alignment are under precise mechanosensitive control.
Sari Tojkander, Katarzyna Ciuba, Pekka Lappalainen   +2 more
doaj   +1 more source

Novel Phosphotidylinositol 4,5-Bisphosphate Binding Sites on Focal Adhesion Kinase. [PDF]

PLoS ONE, 2015
Focal adhesion kinase (FAK) is a protein tyrosine kinase that is ubiquitously expressed, recruited to focal adhesions, and engages in a variety of cellular signaling pathways.
Jun Feng, Blake Mertz
doaj   +1 more source

Abnormal Endothelial Gene Expression Associated With Early Coronary Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background We examined feasibility of a unique approach towards gaining insight into heritable risk for early atherosclerosis: surveying gene expression by endothelial cells from living subjects. Methods and Results Subjects aged
Robert P. Hebbel, Peng Wei, Liming Milbauer, Michel T. Corban, Anna Solovey, James Kiley, Jack Pattee, Lilach O. Lerman, Wei Pan, Amir Lerman   +9 more
doaj   +1 more source

Requirement for focal adhesion kinase in tumor cell adhesion [PDF]

Oncogene, 1999
Focal adhesion kinase (FAK) is a nonreceptor protein tyrosine kinase and a major phosphotyrosine-containing protein. FAK is found in cell-matrix attachment sites (focal adhesions), and is activated on integrin-ligand binding and by other signaling pathways. Several roles have been proposed for FAK; here we report a novel function.
K, Maung, D J, Easty, S P, Hill, D C, Bennett   +3 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

AMBRA1 and FAK1: crosstalking for improved targeted therapy in melanoma

Molecular & Cellular Oncology, 2021
Through genetically engineered mouse models of melanoma, we identified Autophagy/beclin 1 regulator 1 (Ambra1) as novel tumor-suppressor in melanoma. In these settings, loss of Ambra1 associated with the hyperactivation of focal adhesion kinase 1 (Fak1 ...
Luca Di Leo, Daniela De Zio
doaj   +1 more source

Differential Signaling by the Focal Adhesion Kinase and Cell Adhesion Kinase β [PDF]

Journal of Biological Chemistry, 1997
pp125(FAK) and CAKbeta/Pyk2/CadTK/RAFTK are related protein-tyrosine kinases. It is therefore of interest whether CAKbeta shares some of the properties of pp125(FAK). Using recombinant glutathione S-transferase fusion proteins, we show that the C-terminal domains of both proteins bind paxillin in vitro.
M D, Schaller, T, Sasaki
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

ADAM23 in Cardiomyocyte Inhibits Cardiac Hypertrophy by Targeting FAK‐AKT Signaling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Cardiac hypertrophy has been recognized as an important independent risk factor for the development of heart failure and increases the risk of cardiac morbidity and mortality.
Mei Xiang, Hongbo Luo, Jia Wu, Lingyun Ren, Xiangchao Ding, Chuangyan Wu, Jiuling Chen, Shanshan Chen, Hao Zhang, Lu Yu, Yanqiang Zou, Heng Xu, Ping Ye, Manhua Chen, Jiahong Xia   +14 more
doaj   +1 more source