Results 1 to 10 of about 145,198 (308)

Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression. [PDF]

Journal of Cell Biology, 2012
Vascular cell adhesion molecule-1 (VCAM-1) plays important roles in development and inflammation. Tumor necrosis factor-α (TNF-α) and focal adhesion kinase (FAK) are key regulators of inflammatory and integrin-matrix signaling, respectively.
Chen, Xiao Lei, Cheresh, David A, Lawson, Christine, Lim, Ssang-Taek, Miller, Nichol LG, Schlaepfer, David D, Tancioni, Isabelle, Uryu, Sean, Walsh, Colin T, Weis, Sara M   +9 more
core   +6 more sources

Crizotinib inhibits NF2-associated schwannoma through inhibition of focal adhesion kinase 1. [PDF]

Oncotarget, 2016
Neurofibromatosis type 2 (NF2) is a dominantly inherited autosomal disease characterized by schwannomas of the 8th cranial nerve. The NF2 tumor suppressor gene encodes for Merlin, a protein implicated as a suppressor of multiple cellular signaling pathways.
Troutman S, Moleirinho S, Kota S, Nettles K, Fallahi M, Johnson GL, Kissil JL.   +6 more
europepmc   +4 more sources

TGFβ₁ activates c-Jun and Erk1 via α_Vβ₆ integrin [PDF]

Molecular Cancer, 2003
Transforming growth factor β (TGFβ) plays an important role in animal development and many cellular processes. A variety of cellular functions that are required for tumor metastasis are controlled by integrins, a family of cell adhesion receptors ...
Schmidt Christian, Luettich Karsta
doaj   +3 more sources

Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation [PDF]

Molecular Cancer, 2005
Background Interaction with integrin and focal adhesion kinase (FAK) regulates the cancer cell adhesion and invasion into extracellular matrix (ECM). In addition, phosphorylation of FAK correlates with the increase of cell motility and invasion. Adhesion
Takeyama Hiromitsu, Takahashi Hiroki, Matsuo Yoichi, Funahashi Hitoshi, Okada Yuji, Sawai Hirozumi, Manabe Tadao   +6 more
doaj   +3 more sources

EVL is a novel focal adhesion protein involved in the regulation of cytoskeletal dynamics and vascular permeability

Pulmonary Circulation, 2021
Increases in lung vascular permeability is a cardinal feature of inflammatory disease and represents an imbalance in vascular contractile forces and barrier‐restorative forces, with both forces highly dependent upon the actin cytoskeleton.
Joseph B. Mascarenhas, Amir A. Gaber, Tania M. Larrinaga, Rachel Mayfield, Stefanie Novak, Sara M. Camp, Carol Gregorio, Jeffrey R. Jacobson, Anne E. Cress, Steven M. Dudek, Joe G.N. Garcia   +10 more
doaj   +1 more source

Cell Adhesion and Focal Adhesion Kinase Regulate Insulin Receptor Substrate-1 Expression [PDF]

Journal of Biological Chemistry, 2000
Integrins are transmembrane receptors involved in interactions between cells and extracellular matrix proteins. Here we show that cell adhesion regulates insulin receptor substrate-1 (IRS-1) mRNA synthesis. When fibroblasts are held in suspension, lower levels of IRS-1 mRNA, but not of IRS-2 mRNA, are detected, and this effect is due to the negative ...
Lebrun, Patricia, Baron, Véronique, Schlaepfer, David D., Obberghen, Emmanuel van, Hauck, Christof R.   +4 more
openaire   +3 more sources

AMBRA1 and FAK1: crosstalking for improved targeted therapy in melanoma

Molecular & Cellular Oncology, 2021
Through genetically engineered mouse models of melanoma, we identified Autophagy/beclin 1 regulator 1 (Ambra1) as novel tumor-suppressor in melanoma. In these settings, loss of Ambra1 associated with the hyperactivation of focal adhesion kinase 1 (Fak1 ...
Luca Di Leo, Daniela De Zio
doaj   +1 more source

Focal adhesion kinase: Insight into molecular roles and functions in hepatocellular carcinoma [PDF]

, 2017
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Due to the high incidence of post-operative recurrence after current treatments, the identification of new and more effective drugs is required.
Alisi, Anna, Crudele, Annalisa, Gnani, Daniela, Panera, Nadia, Romito, Ilaria   +4 more
core   +5 more sources

Nestin Modulates Airway Smooth Muscle Cell Migration by Affecting Spatial Rearrangement of Vimentin Network and Focal Adhesion Assembly

Cells, 2022
Airway smooth muscle cell migration plays a role in the progression of airway remodeling, a hallmark of allergic asthma. However, the mechanisms that regulate cell migration are not yet entirely understood.
Ruping Wang, Sakeeb Khan, Guoning Liao, Yidi Wu, Dale D. Tang   +4 more
doaj   +1 more source

Deciphering Mode of Action of Functionally Important Regions in the Intrinsically Disordered Paxillin (Residues 1-313) Using Its Interaction with FAT (Focal Adhesion Targeting Domain of Focal Adhesion Kinase). [PDF]

PLoS ONE, 2016
Intrinsically disordered proteins (IDPs) play a major role in various cellular functions ranging from transcription to cell migration. Mutations/modifications in such IDPs are shown to be associated with various diseases.
Muniasamy Neerathilingam, Sneha G Bairy, Sumukh Mysore   +2 more
doaj   +1 more source