Results 1 to 10 of about 83,112 (165)

Crizotinib inhibits NF2-associated schwannoma through inhibition of focal adhesion kinase 1. [PDF]

Oncotarget, 2016
Neurofibromatosis type 2 (NF2) is a dominantly inherited autosomal disease characterized by schwannomas of the 8th cranial nerve. The NF2 tumor suppressor gene encodes for Merlin, a protein implicated as a suppressor of multiple cellular signaling pathways.
Troutman S, Moleirinho S, Kota S, Nettles K, Fallahi M, Johnson GL, Kissil JL.   +6 more
europepmc   +4 more sources

Stretch regulated surface roughness controls macrophage inflammatory polarization through adhesion–chromatin coupling [PDF]

Frontiers in Pharmacology
IntroductionMacrophages are early responders to biomaterial interfaces, but the specific role of surface roughness in regulating macrophage inflammatory phenotypes remains difficult to distinguish from the effects of substrate stiffness and other ...
Gang Yang, Yi Han, Tao Tang, Xu Liu, Hong-yu He, Yong-fu Xiong, Jun-wei Wang, Xiao-song Qing, Chen Zhang   +8 more
doaj   +2 more sources

Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation [PDF]

Molecular Cancer, 2005
Background Interaction with integrin and focal adhesion kinase (FAK) regulates the cancer cell adhesion and invasion into extracellular matrix (ECM). In addition, phosphorylation of FAK correlates with the increase of cell motility and invasion. Adhesion
Takeyama Hiromitsu, Takahashi Hiroki, Matsuo Yoichi, Funahashi Hitoshi, Okada Yuji, Sawai Hirozumi, Manabe Tadao   +6 more
doaj   +3 more sources

EVL is a novel focal adhesion protein involved in the regulation of cytoskeletal dynamics and vascular permeability

Pulmonary Circulation, 2021
Increases in lung vascular permeability is a cardinal feature of inflammatory disease and represents an imbalance in vascular contractile forces and barrier‐restorative forces, with both forces highly dependent upon the actin cytoskeleton.
Joseph B. Mascarenhas, Amir A. Gaber, Tania M. Larrinaga, Rachel Mayfield, Stefanie Novak, Sara M. Camp, Carol Gregorio, Jeffrey R. Jacobson, Anne E. Cress, Steven M. Dudek, Joe G.N. Garcia   +10 more
doaj   +1 more source

Cell Adhesion and Focal Adhesion Kinase Regulate Insulin Receptor Substrate-1 Expression [PDF]

Journal of Biological Chemistry, 2000
Integrins are transmembrane receptors involved in interactions between cells and extracellular matrix proteins. Here we show that cell adhesion regulates insulin receptor substrate-1 (IRS-1) mRNA synthesis. When fibroblasts are held in suspension, lower levels of IRS-1 mRNA, but not of IRS-2 mRNA, are detected, and this effect is due to the negative ...
Lebrun, Patricia, Baron, Véronique, Schlaepfer, David D., Obberghen, Emmanuel van, Hauck, Christof R.   +4 more
openaire   +3 more sources

AMBRA1 and FAK1: crosstalking for improved targeted therapy in melanoma

Molecular & Cellular Oncology, 2021
Through genetically engineered mouse models of melanoma, we identified Autophagy/beclin 1 regulator 1 (Ambra1) as novel tumor-suppressor in melanoma. In these settings, loss of Ambra1 associated with the hyperactivation of focal adhesion kinase 1 (Fak1 ...
Luca Di Leo, Daniela De Zio
doaj   +1 more source

MEK Kinase 1 Interacts with Focal Adhesion Kinase and Regulates Insulin Receptor Substrate-1 Expression [PDF]

Journal of Biological Chemistry, 2003
MEK kinase 1 (MEKK1) has been shown to contribute to the regulation of cell migration, whereas focal adhesion kinase (FAK) is a major player involved in both cell migration and integrin signaling. Here we show that MEKK1 and FAK are co-immunoprecipitated from mouse fibroblasts.
Toshiaki, Yujiri, Ryouhei, Nawata, Toru, Takahashi, Yutaka, Sato, Yukio, Tanizawa, Toshio, Kitamura, Yoshitomo, Oka   +6 more
openaire   +2 more sources

Deciphering Mode of Action of Functionally Important Regions in the Intrinsically Disordered Paxillin (Residues 1-313) Using Its Interaction with FAT (Focal Adhesion Targeting Domain of Focal Adhesion Kinase). [PDF]

PLoS ONE, 2016
Intrinsically disordered proteins (IDPs) play a major role in various cellular functions ranging from transcription to cell migration. Mutations/modifications in such IDPs are shown to be associated with various diseases.
Muniasamy Neerathilingam, Sneha G Bairy, Sumukh Mysore   +2 more
doaj   +1 more source

Nestin Modulates Airway Smooth Muscle Cell Migration by Affecting Spatial Rearrangement of Vimentin Network and Focal Adhesion Assembly

Cells, 2022
Airway smooth muscle cell migration plays a role in the progression of airway remodeling, a hallmark of allergic asthma. However, the mechanisms that regulate cell migration are not yet entirely understood.
Ruping Wang, Sakeeb Khan, Guoning Liao, Yidi Wu, Dale D. Tang   +4 more
doaj   +1 more source

Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression [PDF]

Journal of Cell Biology, 2012
Vascular cell adhesion molecule–1 (VCAM-1) plays important roles in development and inflammation. Tumor necrosis factor–α (TNF-α) and focal adhesion kinase (FAK) are key regulators of inflammatory and integrin–matrix signaling, respectively. Integrin costimulatory signals modulate inflammatory gene expression, but the important control points between ...
Lim, Ssang-Taek, Miller, Nichol LG, Chen, Xiao Lei, Tancioni, Isabelle, Walsh, Colin T, Lawson, Christine, Uryu, Sean, Weis, Sara M, Cheresh, David A, Schlaepfer, David D   +9 more
openaire   +4 more sources