Results 21 to 30 of about 145,198 (308)

Flotillins Regulate Focal Adhesions by Interacting with α-Actinin and by Influencing the Activation of Focal Adhesion Kinase

Cells, 2018
Cell–matrix adhesion and cell migration are physiologically important processes that also play a major role in cancer spreading. In cultured cells, matrix adhesion depends on integrin-containing contacts such as focal adhesions. Flotillin-1 and flotillin-
Antje Banning, Tanja Babuke, Nina Kurrle, Melanie Meister, Mika O. Ruonala, Ritva Tikkanen   +5 more
doaj   +1 more source

Signaling via ITGB1/FAK and microfilament rearrangement mediates the internalization of Leptospira interrogans in mouse J774A.1 macrophages [PDF]

Archives of Biological Sciences, 2015
Leptospirosis caused by pathogenic Leptospira species is a worldwide zoonotic 2 infectious disease, but the mechanisms of leptospiral internalization remain poorly understood.
Zhao Xin, Sun Ai-Hua, Ge Yu-Mei, Wang Huan, Yan Jie   +4 more
doaj   +1 more source

FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells [PDF]

, 2014
Receptor Tyrosine Kinases (RTKs) and Focal Adhesion Kinase (FAK) regulate multiple signalling pathways, including mitogen-activated protein (MAP) kinase pathway. FAK interacts with several RTKs but little is known about how FAK regulates their downstream
A Bergmann, A Boulay, A Ueda, AC Dar, B Corkery, B Gabriel, BA Edgar, BA Hay, BJ Dickson, C Grabbe, CJ Marshall, D Tenenbaum, DD Schlaepfer, DJ Sieg, E Macia, E Rainero, E Rainero, E Sandilands, E Sandilands, Emma Sandilands, FD Karim, FJ Diaz-Benjumea, G Adam, GL Fox, I Bongarzone, I Plaza-Menacho, I Rebay, Iain MacPherson, IH Gelman, J Cordero, J Fujimoto, J Verdu, J Zhao, Jesica Diaz Vera, Jim C. Norman, JR Infante, JT Parsons, JT Price, Juan Pablo Macagno, K Blochlinger, K Halfar, K Mesaki, K Sawamoto, L Henriksen, L Sadowski, LV Owens, M Agochiya, M Ayaki, M Freeman, M Grieco, M Miaczynska, M Roberts, M Santoro, M Therrien, M Vidal, M Vidal, Marcos Vidal, Margaret Frame, Marshall S. Horwitz, MC Frame, ME Grether, ME Irwin, MM Bradford, P Kurada, P-I Tsai, PM Siesser, R Gleichauf, R Ohta, RD Read, RH Palmer, Ruth Palmer, S Leboulleux, S Murakami, S Rizzolio, S Sigismund, SA Speicher, SM Jhiang, SY Chen, T Das, T Matsuo, T-H Chen, W Long, WG Cance, X Zhao, Y Zheng, Yachuan Yu, Z Lu   +86 more
core   +4 more sources

Netrin‐1 Preserves Blood‐Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background Netrin‐1 (NTN‐1) has been established to be a novel intrinsic regulator of blood‐brain barrier (BBB) maintenance. This study was carried out to investigate the potential roles of exogenous NTN‐1 in preserving BBB integrity after experimental ...
Zongyi Xie, Budbazar Enkhjargal, Cesar Reis, Lei Huang, Weifeng Wan, Jiping Tang, Yuan Cheng, John H. Zhang   +7 more
doaj   +1 more source

Diverse cell junctions with unique molecular composition in tissues of a sponge (Porifera)

EvoDevo, 2019
The integrity and organization of animal tissues depend upon specialized protein complexes that mediate adhesion between cells with each other (cadherin-based adherens junctions), and with the extracellular matrix (integrin-based focal adhesions ...
Jennyfer M. Mitchell, Scott A. Nichols
doaj   +1 more source

Inhibition of lysyl oxidase‐like 2 overcomes adhesion‐dependent drug resistance in the collagen‐enriched liver cancer microenvironment

Hepatology Communications, 2022
The tumor microenvironment (TME) is considered to be one of the vital mediators of tumor progression. Extracellular matrix (ECM), infiltrating immune cells, and stromal cells collectively constitute the complex ecosystem with varied biochemical and ...
Lanqi Gong, Yu Zhang, Yuma Yang, Qian Yan, Jifeng Ren, Jie Luo, Yuen Chak Tiu, Xiaona Fang, Beilei Liu, Raymond Hiu Wai Lam, Ka‐On Lam, Anne Wing‐Mui Lee, Xin‐Yuan Guan   +12 more
doaj   +1 more source

αV-Integrins Are Required for Mechanotransduction in MDCK Epithelial Cells [PDF]

, 2013
The properties of epithelial cells within tissues are regulated by their immediate microenvironment, which consists of neighboring cells and the extracellular matrix (ECM).
Engler, Adam J., Friedrichs, Jens, Manninen, Aki, Matlin, Karl S., Moyano, Jose V., Muller, Daniel J., Myllymäki, Satu M., Strohmeyer, Nico, Teräväinen, Terhi P., Wu, Chuanyue   +9 more
core   +3 more sources

Endothelin-1 stimulates tyrosine phosphorylation of p125 focal adhesion kinase in mesangial cells. [PDF]

Journal of the American Society of Nephrology, 1995
Endothelin-1 (ET-1) is known to induce the contraction and proliferation of glomerular mesangial cells. Because ET-1 was found to stimulate the tyrosine phosphorylation of unidentified cellular proteins in cultured mesangial cells, protein tyrosine kinase might serve as one of the important signals leading to various functions of ET-1.
M, Haneda, R, Kikkawa, D, Koya, T, Shikano, T, Sugimoto, M, Togawa, Y, Shigeta   +6 more
openaire   +2 more sources

The Neurod1/4-Ntrk3-Src pathway regulates gonadotrope cell adhesion and motility

Cell Death Discovery, 2023
Pituitary gonadotrope cells are essential for the endocrine regulation of reproduction in vertebrates. These cells emerge early during embryogenesis, colonize the pituitary glands and organize in tridimensional networks, which are believed to be crucial ...
Charles Le Ciclé, Vincent Pacini, Nicolas Rama, Servane Tauszig-Delamasure, Eloïse Airaud, Florence Petit, Simon de Beco, Joëlle Cohen-Tannoudji, David L’hôte   +8 more
doaj   +1 more source

Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. [PDF]

, 2014
To enable new blood vessel growth, endothelial cells (ECs) express neuropilin 1 (NRP1), and NRP1 associates with the receptor tyrosine kinase VEGFR2 after binding the vascular endothelial growth factor A (VEGF) to enhance arteriogenesis.
Alessandro Fantin, Anastasia Lampropoulou, Anissa Chikh, Anselmi, Ballmer-Hofer, Baruzzi, Birukova, Buchdunger, Campochiaro, Carmeliet, Casanovas, Chen, Chen, Chislock, Cho, Choi, Christiana Ruhrberg, Clark, Claudio Raimondi, Colicelli, Connor, Cui, Cujec, Dejana, Druker, Fantin, Fantin, Fantin, Fantin, Foxton, Fukasawa, Gerhardt, Gerhardt, Herzog, Kawamura, Kawasaki, Kim, Kitsukawa, Koch, Lanahan, Lanahan, Laura Denti, Lewis, Lewis, Mamluk, Murga, Nishijima, Pan, Pan, Parsons, Pasapera, Phng, Raimondi, Ren, Robinson, Roig, Rosenfeld, Ruhrberg, Ruhrberg, Saint-Geniez, Salikhova, Shimizu, Shojaei, Smith, Soker, Sottile, Stenzel, Tvorogov, Uemura, Valdembri, Wang, Welti, Yaqoob, Zaidel-Bar, Zhuang   +74 more
core   +4 more sources